Results 121 to 130 of about 743,722 (313)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

DNA methylation modification in Idiopathic pulmonary fibrosis

Frontiers in Cell and Developmental Biology
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial lung disease with a prognosis worse than lung cancer. It is a fatal lung disease with largely unknown etiology and pathogenesis, and no effective therapeutic ...
Lu Ren, Yan-Fen Chang, Shi-He Jiang, Xiao-Hong Li, Hai-Peng Cheng   +4 more
doaj   +1 more source

Distribution Pattern of N6-Methyladenine DNA Modification in the Seashore Paspalum (Paspalum vaginatum) Genome. [PDF]

Front Plant Sci, 2022
Hao JS, Xing JF, Hu X, Wang ZY, Tang MQ, Liao L.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease

Neural Plasticity, 2019
Tau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct ...
Chao-Chao Yu, Tao Jiang, Ao-Fei Yang, Yan-Jun Du, Miao Wu, Li-Hong Kong   +5 more
doaj   +1 more source

DNAModAnnot: a R toolbox for DNA modification filtering and annotation. [PDF]

Bioinformatics, 2021
Hardy A, Matelot M, Touzeau A, Klopp C, Lopez-Roques C, Duharcourt S, Defrance M.   +6 more
europepmc   +1 more source

DNA modification

, 2017
The invention relates to the field of genetic engineering, and to the modification of nucleic acids and organismal genomes in particular. Specifically, the invention concerns the chemical modification of nucleic acids for the improved transformation of cells.
Vlot, M., Brouns, S.J.J.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

N⁴-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana. [PDF]

Genome Biol, 2022
Wang S, Xie H, Mao F, Wang H, Wang S, Chen Z, Zhang Y, Xu Z, Xing J, Cui Z, Gao X, Jin H, Hua J, Xiong B, Wu Y.   +14 more
europepmc   +1 more source

Ecological modernization versus sustainable development: the case of genetic modification regulation in New Zealand

, 2009
Ecological modernization and sustainable development are the two dominant paradigms in environmental policy. This paper assesses the implications of competing understandings of ecological modernization and sustainable development using the case of ...
Wright, Jeanette Marie, Priya Kurian, Jeanette Wright, Kurian, Priya A.   +3 more
core   +1 more source