EPIGENETIC MODIFICATIONS OF SWINE GENOME [PDF]
Poljoprivreda, 2013 Epigenetics is represents a new way of genome analysis, respectively gene expression that occurs without DNA sequence change. Changes that occur are epigenetic modifications and they include post-translational histone modification and DNA methylation ...
Kristina Budimir +2 more
doaj
4acCPred: Weakly supervised prediction of N 4-acetyldeoxycytosine DNA modification from sequences. [PDF]
Mol Ther Nucleic Acids, 2022 Zhou J, Wang X, Wei Z, Meng J, Huang D.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Distribution Pattern of N6-Methyladenine DNA Modification in the Seashore Paspalum (Paspalum vaginatum) Genome. [PDF]
Front Plant Sci, 2022 Hao JS +5 more
europepmc +1 more source
Chromatin Preparation and Chromatin Immuno-precipitation from Drosophila Embryos
, 2016 This protocol provides specific details on how to perform Chromatin immunoprecipitation (ChIP) from Drosophila embryos. ChIP allows the matching of proteins or histone modifications to specific genomic regions.
Iovino, N., Latrielle, D., Löser, E.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
DNAModAnnot: a R toolbox for DNA modification filtering and annotation. [PDF]
Bioinformatics, 2021 Hardy A +6 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease
Neural Plasticity, 2019 Tau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct ...
Chao-Chao Yu +5 more
doaj +1 more source
N4-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana. [PDF]
Genome Biol, 2022 Wang S +14 more
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