Results 251 to 260 of about 299,286 (332)

Mutation patterns and prognostic potentiality of homologous recombination repair genes in gliomas. [PDF]

BMC Cancer
Bai H, Liu Y, Ji C, Zhang Q, Luo N, Zhang X, Zheng Z.   +6 more
europepmc   +1 more source

Non-invasive and simple methods for sampling rabbit DNA for PCR analysis of melanocortin 1 receptor (MC1R) gene mutations: a technical note

, 2010
Luca Fontanesi, Marco Tazzoli, Vincenzo Russo   +2 more
openalex   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations. [PDF]

MedComm (2020)
Kang J, Lim DM, Kim YJ, Shim H, Kim TY, Park KJ, Kang SB, Yu CS, Lee JL, Yu Y, Lee H, Kwon EJ, Kim HM, Mun S, Kwak D, Lee HS, Heo HJ, Kim EK, Baek SE, Park JW, Bae SU, Kwon TK, Lee D, Kim K, Oh CK, Ko DS, Cho S, Park HR, Kim S, Kim YH.   +29 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Targeted next-generation sequencing reveals genomic differences between male and female breast cancer. [PDF]

Transl Cancer Res
Zhu J, Xu S, Hua W, Wang M, Zhang S, Lu P, Wu H.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Distinct genomic subgroups and mutational patterns in undifferentiated/dedifferentiated endometrial carcinoma. [PDF]

BMC Cancer
Huang CY, Chao A, Lin CY, Rozen SG, Chao AS, Chang CB, Tung HJ, Wu RC, Lai CH.   +8 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation. [PDF]

Sci Adv
Hatton GH, James SR, Mason AS, Gawne RT, Vogel H, Hogg K, Boukani P, Swinscoe G, Khan A, Welberry Smith M, Carpenter MA, Masood O, Martincorena I, Macdonald A, Harris RS, Starrett GJ, Southgate J, Baker SC.   +17 more
europepmc   +1 more source