Results 261 to 270 of about 188,397 (314)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Distinct mutational signature and clonal evolution in constitutional mismatch repair deficiency-associated high-grade gliomas. [PDF]

iScience
Li C, Erson-Omay EZ, Koksal Y, Unal E, Kara B, Bilguvar K, Paksoy Y, Durmus NA, Kurtsoy A, Per H, Østergaard JR, Günel M, Çağlayan AO.   +12 more
europepmc   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

PULPO: pipeline of understanding large-scale patterns of oncogenomic signatures. [PDF]

Bioinformatics
Portasany-Rodríguez M, Soria-Alcaide G, Sánchez EG, Ivanova M, Gómez A, Giménez R, Lalchandani J, García-Aguilera G, Alemán-Arteaga S, Saiz-Ladera C, Ramírez-Orellana M, Garcia-Martinez J.   +11 more
europepmc   +1 more source

Unraveling the nexus: Tumor mutational burden, PD-L1 expression, and oncogenic alterations in non-small cell lung cancer cytology specimens. [PDF]

Cancer Cytopathol
Dai M, San Lucas FA, Alvarez H, Ballester L, Chen H, Patel KP, Rashid A, Rao S, Routbort MJ, Sura G, Sweeney K, Toruner G, Wei P, Yang R, Dang H, Luthra R, Roy-Chowdhuri S.   +16 more
europepmc   +1 more source

Delineation of the heterogeneity underlying genomic instability in hereditary breast cancers reveals four disease subtypes. [PDF]

Exp Mol Med
Kim S, Lee S, Kim H, Kang SJ, Chae H, Kim BJ, Kong J, Kang MC, Kim TM, Kong SY.   +9 more
europepmc   +1 more source

The selective dynamics of interruptions at short tandem repeats. [PDF]

Genetics
Goldberg ME, Dashnow H, Harris K, Quinlan AR.   +3 more
europepmc   +1 more source

Unraveling the molecular mechanisms of smoking-associated non-small cell lung cancer: a comprehensive analysis of genetic, therapeutic, and immunological. [PDF]

J Thorac Dis
Li H, Hou D, Wang L, Kang L, Wang K, Wang H, Li H.   +6 more
europepmc   +1 more source

Reprogramming tumor immunity through APOBEC3s-mediated mutagenesis: from genome instability to immune checkpoint interactions. [PDF]

Front Immunol
Li Q, Wan W, Zhu Z, Lin X, Wang F, Li M, Guo H, Yang Y.   +7 more
europepmc   +1 more source