Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities [PDF]
Cell Discovery, 2023 Life science studies involving clustered regularly interspaced short palindromic repeat (CRISPR) editing generally apply the best-performing guide RNA (gRNA) for a gene of interest.
Heng Zhang +8 more
doaj +2 more sources
DNA nucleotidylexotransferase of normal persons and leukemic patients.
Clinical Chemistry, 1980 Abstract We describe a relatively simple and rapid assay for DNA nucleotidylexotransferase (EC 2.7.7.31) activity in normal lymphocytes and leukemic cells from blood and (or) bone marrow of patients with various types of leukemia. We followed the method of Beutler and Kuhl (Am. J. Clin. Pathol. 70: 733, 1978) but separated the product
W G Yasmineh
exaly +3 more sources
Epigenetic silencing of V(D)J recombination is a major determinant for selective differentiation of mucosal-associated invariant t cells from induced pluripotent stem cells. [PDF]
PLoS ONE, 2017 Mucosal-associated invariant T cells (MAITs) are innate-like T cells that play a pivotal role in the host defense against infectious diseases, and are also implicated in autoimmune diseases, metabolic diseases, and cancer.
Yutaka Saito +3 more
doaj +1 more source
Template-independent enzymatic functionalization of DNA oligonucleotides with environment-sensitive nucleotide probes using terminal deoxynucleotidyl transferase [PDF]
Nucleic Acids ResearchSeergazhi Srivatsan +2 more
exaly +2 more sources
Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase. [PDF]
J Am Chem Soc, 2023 Schneider LA +3 more
europepmc +1 more source
Insight into the mechanism of DNA synthesis by human terminal deoxynucleotidyltransferase. [PDF]
Life Sci Alliance, 2022 Kuznetsova AA +5 more
europepmc +1 more source
Spatially Selective Electrochemical Cleavage of a Polymerase-Nucleotide Conjugate. [PDF]
ACS Synth Biol, 2023 Smith JA +6 more
europepmc +1 more source
Target-triggered cascade signal amplification for sensitive electrochemical detection of SARS-CoV-2 with clinical application. [PDF]
Anal Chim Acta, 2022 Deng Y +8 more
europepmc +1 more source
Label-Free miRNA-21 Analysis Based on Strand Displacement and Terminal Deoxynucleotidyl Transferase-Assisted Amplification Strategy. [PDF]
Biosensors (Basel), 2022 Yan Y, Zhao H, Fang Y, Ma C, Chen J.
europepmc +1 more source