Results 21 to 30 of about 1,451,982 (120)

Genotoxikus hatásra bekövetkező funkcionális és strukturális DNS változások = Functional and structural changes in DNA upon genotoxic effects [PDF]

, 2008
Morfológiai és biokémiai vizsgálataink arra utalnak, hogy a a genotoxikus hatások kategorizálhatók az okozott kromatin változások alapján. A kemotoxikus változások potenciális diagnosztikus jelentősége miatt vizsgáltuk a nehézfémek (elsősosrban kadmium) (
Szepessy, Edit, Rőszer, Tamás, Bánfalvi, Gáspár, Jenei, Zsolt, Serfőző, Zoltán, Nagy, Gábor György, B. Kiss, Zsigmond   +6 more
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Prediction of Spontaneous Regression of Cervical Intraepithelial Neoplasia Lesions Grades 2 and 3 by Proteomic Analysis

International Journal of Proteomics, Volume 2014, Issue 1, 2014., 2014
Regression of cervical intraepithelial neoplasia (CIN) 2‐3 to CIN 1 or less is associated with immune response as demonstrated by immunohistochemistry in formaldehyde‐fixed paraffin‐embedded (FFPE) biopsies. Proteomic analysis of water‐soluble proteins in supernatants of biopsy samples with LC‐MS (LTQ‐Orbitrap) was used to identify proteins predictive ...
Kai-Erik Uleberg, Irene Tveiterås Øvestad, Ane Cecilie Munk, Cato Brede, Bianca van Diermen, Einar Gudlaugsson, Emiel A. M. Janssen, Anne Hjelle, Jan P. A. Baak, Jen-Fu Chiu   +9 more
wiley   +1 more source

Cellular Processing Pathways Contribute to the Activation of Etoposide- Induced DNA Damage Responses

, 2009
Cytotoxic action (tumor cell killing) and carcinogenic side effect ( therapy-related secondary leukemia) of etoposide are closely related to its ability in stabilizing topoisomerase II cleavable complex (TOP2cc), a unique form of protein- linked DNA ...
FAN, JIA-RONG;PENG, AN-LIN;LO, SHU-CHI;HUANG, TING-HSIANG;LI, TSAI-KUN, 范嘉榕;彭安林;羅淑祺;黃鼎翔;李財坤   +1 more
core   +1 more source

Electronic transport in DNA [PDF]

, 2005
We study the electronic properties of DNA by way of a tight-binding model applied to four particular DNA sequences. The charge transfer properties are presented in terms of localization lengths (crudely speaking, the length over which electrons travel).
Klotsa, Daphne, Turner, Matthew S., Römer, Rudolf A., Roemer, Rudolf A.   +3 more
core   +1 more source

Molecular mechanisms and kinetics between DNA and DNA binding ligands [PDF]

, 2005
Sischka A, Tönsing K, Eckel R, et al. Molecular mechanisms and kinetics between DNA and DNA binding ligands. Biophysical Journal. 2005;88(1):404-411.Mechanical properties of single double-stranded DNA (dsDNA) in the presence of different binding ligands ...
Anselmetti, Dario, Wilking, Sven David, Ros, Robert, Toensing, Katja, Sischka, Andy, Eckel, Rainer, Sewald, Norbert, Tönsing, Katja, Sewald, Norbert ; https://orcid.org/, Anselmetti, Dario ; https://orcid.org/   +9 more
core   +1 more source

Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click‐Reactive NTP Analogues

ChemBioChem, Volume 25, Issue 1, January 2, 2024.
A new chemoenzymatic method involving dual incorporation of γ‐ and 3′‐modified NTPs allows sequential 5′‐ and 3′‐end labelling of DNA and RNA molecules. Abstract Post‐synthetic modification of nucleic acid structures with clickable functionality is a versatile tool that facilitates many emerging applications, including immune evasion, enhancements in ...
Eva S. Schönegger, Antony Crisp, Marco Radukic, Jonas Burmester, Thomas Frischmuth, Thomas Carell   +5 more
wiley   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Dominguez Salas, Paula, Dominguez-Salas, P, Prentice, AM, Sophie E. Moore, Cox, SE, Dominguez-Salas, Paula, Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Andrew M. Prentice, Moore, SE, Moore, Sophie E, Hennig, BJ, Cox, Sharon E, Prentice, Andrew M., Moore, Sophie E., Hennig, Branwen J., Branwen J. Hennig, Sharon E. Cox, Cox, Sharon E.   +19 more
core   +1 more source

A DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B and T cell responses in outbred animals [PDF]

, 2007
We developed a vaccine construct in which a BVP22 domain and an invariant-chain major histocompatibility complex class II-targeting motif capable of enhancing dendritic cell antigen uptake and presentation were fused to a sequence encoding a B- and T ...
Palmer, Guy H, Zhuang, Yan, Mwangi, W, Howard, CJ, Aida, Yoko, Hunter, Beverly J, Splitter, Gary A, Brown, WC, Palmer, GH, Hunter, BJ, Aida, Y, Davies, Christopher J, Brown, Wendy C, Davies, CJ, Mwangi, Waithaka, Splitter, GA, Zhuang, Y, Hope, Jayne; id_orcid, Howard, Chris J, Hope, Jayne C   +19 more
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Repair of oxidatively-induced clustered DNA lesions, after exposure of human cancer cells to ionizing radiation

, 2017
In the present thesis, the induction and repair of complex DNA lesions, double strand breaks (DSBs) of high complexity accompanied by oxidatively-induced base lesions in their close vicinity were studied after exposure to ionizing radiation (IR) of ...
Νικητάκη, Ζαχαρένια, Νικητάκη, Ζαχαρένια, Nikitaki, Zacharenia   +2 more
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Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican   +18 more
core   +1 more source