Results 11 to 20 of about 1,451,982 (120)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer. [PDF]

Mol Oncol
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Jeremian R, Sivachandran S, Galati M, Ramchatesingh B, Rijal H, Hanna J, Netchiporouk E, Chergui M, Redpath M, Abou Setah S, Litvinov IV.   +10 more
europepmc   +2 more sources

DNTT activation, TdT‐aided gene length mutation, and better prognosis in ATG‐based regimen allo‐HSCT in AML

Molecular Carcinogenesis, Volume 62, Issue 5, Page 665-675, May 2023., 2023
Abstract This study aimed to investigate the relationship between anomalous DNA nucleotidylexotransferase (DNTT) activation and the mutagenesis of gene length mutations (LMs) in acute myeloid leukemia (AML), and the relevance of their prognosis in antithymocyte globulin (ATG)‐based regimen allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Xiaosu Zhou, Daijing Nie, Yang Zhang, Zhixiu Liu, Yanli Zhao, Jianping Zhang, Fang Wang, Jiancheng Fang, Panxiang Cao, Xue Chen, Xiaoli Ma, Lili Yuan, Jiaqi Chen, Yincheng Tan, Qihui Chen, Ming Liu, Mingyue Liu, Yijun Liu, Qisheng Wu, Peihua Lu, Hongxing Liu   +20 more
wiley   +1 more source

Using digital RNA counting to establish flow cytometry diagnostic criteria for subtypes of CD34+ canine acute leukaemia

Veterinary and Comparative Oncology, Volume 20, Issue 3, Page 710-719, September 2022., 2022
Abstract Canine acute leukaemia is a heterogeneous neoplasm with multiple phenotypes. Criteria to subtype acute leukaemia by flow cytometry have not been validated. The goal of this study was to develop a panel of antibodies and objective antigen expression criteria for the assignment of lymphoid or myeloid lineage by flow cytometry.
R. Adam Harris, Emily D. Rout, Janna A. Yoshimoto, Paul R. Avery, Anne C. Avery   +4 more
wiley   +1 more source

Increased accuracy of genomic predictions for growth under chronic thermal stress in rainbow trout by prioritizing variants from GWAS using imputed sequence data

Evolutionary Applications, Volume 15, Issue 4, Page 537-552, April 2022., 2022
Abstract Through imputation of genotypes, genome‐wide association study (GWAS) and genomic prediction (GP) using whole‐genome sequencing (WGS) data are cost‐efficient and feasible in aquaculture breeding schemes. The objective was to dissect the genetic architecture of growth traits under chronic heat stress in rainbow trout (Oncorhynchus mykiss) and ...
Grazyella M. Yoshida, José M. Yáñez
wiley   +1 more source

Known and potential molecules associated with altered B cell development leading to predominantly antibody deficiencies

Pediatric Allergy and Immunology, Volume 32, Issue 8, Page 1601-1615, November 2021., 2021
Abstract Predominantly antibody deficiencies (PADs) encompass a heterogeneous group of disorders characterized by low immunoglobulin serum levels in the presence or absence of peripheral B cells. Clinical presentation of affected patients may include recurrent respiratory and gastrointestinal infections, invasive infections, autoimmune manifestations ...
Parisa Amirifar, Reza Yazdani, Gholamreza Azizi, Mohammad Reza Ranjouri, Anne Durandy, Alessandro Plebani, Vassilios Lougaris, Lennart Hammarstrom, Asghar Aghamohammadi, Hassan Abolhassani, Fabio Candotti   +10 more
wiley   +1 more source

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]

, 2002
Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D., Stokes, Matthew P., Van Hatten, Ruth, Howard D. Lindsay (4252681), Howard D. Lindsay, W. Matthew Michael, Ruth Van Hatten (16043837), W. Matthew Michael (3211092), Ruth Van Hatten, Matthew P. Stokes, Matthew P. Stokes (9707794), Michael, W. Matthew   +11 more
core   +5 more sources

Deciphering tissue‐based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors

Molecular Oncology, Volume 14, Issue 4, Page 721-741, April 2020., 2020
Thymic epithelial tumors (TETs) belong to a group of tumors that rarely occur, but have unresolved mechanisms and heterogeneous clinical behaviors. Current care of TET patients demands protein biomarkers of high sensitivity and specificity for accurate histological classification.
Xin Ku, Qiangling Sun, Lei Zhu, Zhitao Gu, Yuchen Han, Ning Xu, Chen Meng, Xiaohua Yang, Wei Yan, Wentao Fang   +9 more
wiley   +1 more source

The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review. [PDF]

Adv Hematol
Epigenetic regulation has been thoroughly investigated in recent years and has emerged as an important aspect of chronic lymphocytic leukemia (CLL) biology. Characteristic aberrant features such as methylation patterns and global DNA hypomethylation were the early findings of the research during the last decades.
Chatzidavid S, Kontandreopoulou CN, Giannakopoulou N, Diamantopoulos PT, Stafylidis C, Kyrtsonis MC, Dimou M, Panayiotidis P, Viniou NA.   +8 more
europepmc   +2 more sources

Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell

Stem Cells International, Volume 2016, Issue 1, 2016., 2016
Nasal olfactory mucosa mesenchymal stem cells (OM‐MSCs) have the ability to promote regeneration in the nervous system in vivo. Moreover, with view to the potential for clinical application, OM‐MSCs have the advantage of being easily accessible from patients and transplantable in an autologous manner, thus eliminating immune rejection and contentious ...
Lite Ge, Miao Jiang, Da Duan, Zijun Wang, Linyu Qi, Xiaohua Teng, Zhenyu Zhao, Lei Wang, Yi Zhuo, Ping Chen, Xijing He, Ming Lu, Heinrich Sauer   +12 more
wiley   +1 more source

Differences in miRNA and mRNA Profile of Papillary Thyroid Cancer Variants

International Journal of Endocrinology, Volume 2016, Issue 1, 2016., 2016
Papillary thyroid cancer (PTC) can be divided into classical variant of PTC (cPTC), follicular variant of PTC (fvPTC), and tall cell variant (tcPTC). These variants differ in their histopathology and cytology; however, their molecular background is not clearly understood. Our results shed some new light on papillary thyroid cancer biology as new direct
Tomasz Stokowy, Danuta Gawel, Bartosz Wojtas, Diego Russo   +3 more
wiley   +1 more source