Results 41 to 50 of about 6,763 (148)

“Expanding the Lactococcal Cell Wall Polysaccharide Paradigm: Novel Structures and Metabolic Pathways in the Emerging Dairy Species Pseudolactococcus laudensis and Pseudolactococcus raffinolactis”

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study characterizes the genetic diversity of Pseudolactococcus laudensis and Pseudolactococcus raffinolactis regarding cell wall polysaccharides (CWPS) and exopolysaccharide (EPS) biosynthesis, uncovering novel genotypes and biosynthetic pathways.
Axel Soto‐Serrano, Irina Sadovskaya, Evgeny Vinogradov, Wenwen Li, Jun‐Hyeok Yu, Kelsey White, Douwe van Sinderen, Lukasz Krych, Paulina Deptula, Jennifer Mahony   +9 more
wiley   +1 more source

Study of the Aminoglycoside Subsistence Phenotype of Bacteria Residing in the Gut of Humans and Zoo Animals [PDF]

, 2016
Recent studies indicate that next to antibiotic resistance, bacteria are able to subsist on antibiotics as a carbon source. Here we evaluated the potential of gut bacteria from healthy human volunteers and zoo animals to subsist on antibiotics.
Gerrit eBor, Hauke eSmidt, Mark W.J. evan Passel, Mark W.J. evan Passel, Teresita De Jesus eBello Gonzalez, Tina eZuidema   +5 more
core   +3 more sources

Genome‐Driven Analysis Reveals the Biotechnological Potential of a Novel Paenibacillus sp. Isolated From Crude Oil

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida, Carlos Miguel Nóbrega Mendonça, Leandro Marcio Moreira, Ricardo Pinheiro de Souza Oliveira, Alessandro de Mello Varani, Mauro de Medeiros Oliveira   +5 more
wiley   +1 more source

Infrared Spectroscopy Coupled with a Dispersion Model for Quantifying the Real-Time Dynamics of Kanamycin Resistance in Artificial Microbiota [PDF]

, 2017
Overusage of antibiotics leads to the widespread induction of antibiotic-resistance genes (ARGs). Developing an approach to allow real-time monitoring and fast prediction of ARGs dynamics in clinical or environmental samples has become an urgent matter ...
Jin, Naifu, Martin, Francis L, Paraskevaidi, Maria, Semple, Kirk T., Zhang, Dayi   +4 more
core   +2 more sources

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the african trypanosome [PDF]

, 2013
Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and progression of DNA replication.
Aguilera, Aidan J. Doherty, Alsford, Altschul, Brun, Burton, Bétous, Callegari, Callegari, Daigaku, David Horn, Della, di Caprio, Diamant, El-Sayed, Elvers, Frick, Garg, Glover, Glover, Godoy, Heller, Hines, Hines, Hopfner, Iyer, Jansen, Jansen, Jozwiakowski, Karras, Kuchta, Lange, Lao-Sirieix, Lazzaro, Lehmann, Li, Lopes, Lucy Glover, Muzi-Falconi, Passos-Silva, Pitcher, Plosky, Proudfoot, Rastogi, Rey, Rupp, Sale, Sean G. Rudd, Siegel, Stanislaw K. Jozwiakowski, Tiengwe, Tiengwe, Ulrich, van Luenen, Waters, Waters, Woodward   +56 more
core   +4 more sources

Beyond tumour suppression: cGAS‐STING pathway in urologic malignancies: Context‐dependent duality and therapeutic implications

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
The context‐dependent duality of cGAS–STING signalling in urologic tumours is revealed. Targeting the STING pathway, in combination with immunotherapies and gene therapies, enhances the anti‐tumour response. Sex hormone differences in urological malignancies are correlated with the cGAS–STING pathway.
Qi Wei, Kui Zhao, Yifan Wu, Wenhui Wu, Na Hao   +4 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source