Results 41 to 50 of about 2,027,606 (189)

MAB21L1 loss of function causes a syndromic neurodevelopmental disorder with distinctive cerebellar, ocular, craniofacial and genital features (COFG syndrome). [PDF]

, 2019
BACKGROUND: Putative nucleotidyltransferase MAB21L1 is a member of an evolutionarily well-conserved family of the male abnormal 21 (MAB21)-like proteins.
Altunoglu, U, Bakey, Z, Bauer, P, Boustany, R-M, Ercan-Sencicek, G, Gleeson, JG, Gunel, M, Hauser, N, James, KN, Kayserili, H, Maroofian, R, Miller, R, Najafi, M, Rad, A, Saeidi, K, Sahebzamani, A, Schmidts, M, Stanley, V, Wu, K, Yeşil, G, Çağlayan, AO   +20 more
core   +3 more sources

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, Volume 15, Issue 12, Page 2001-2020, December 2025.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology [PDF]

, 2015
The interleukin enhancer binding factors ILF2 (NF45) and ILF3 (NF90/NF110) have been implicated in various cellular pathways, such as transcription, microRNA (miRNA) processing, DNA repair, and translation, in mammalian cells.
Badertscher, Lukas, Bammert, Lukas, Horváth, Péter, Koós, Krisztián, Montellese, Christian, Wandrey, Franziska   +5 more
core   +1 more source

Molecular Characterization of a DNA Polymerase from Thermus thermophilus MAT72 Phage vB_Tt72: A Novel Type-A Family Enzyme with Strong Proofreading Activity

International Journal of Molecular Sciences, 2022
We present a structural and functional analysis of the DNA polymerase of thermophilic Thermus thermophilus MAT72 phage vB_Tt72. The enzyme shows low sequence identity ( 75 °C.
Sebastian Dorawa, Olesia Werbowy, M. Płotka, A. Kaczorowska, J. Makowska, L. Kozlowski, Ó. Fridjónsson, G. Hreggvidsson, A. Aevarsson, T. Kaczorowski   +9 more
semanticscholar   +1 more source

The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]

, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas, Drach, Kinoshita, Lim, Noguchi, Ohkura, Sazer, Suzuki   +7 more
core   +2 more sources

“Expanding the Lactococcal Cell Wall Polysaccharide Paradigm: Novel Structures and Metabolic Pathways in the Emerging Dairy Species Pseudolactococcus laudensis and Pseudolactococcus raffinolactis”

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study characterizes the genetic diversity of Pseudolactococcus laudensis and Pseudolactococcus raffinolactis regarding cell wall polysaccharides (CWPS) and exopolysaccharide (EPS) biosynthesis, uncovering novel genotypes and biosynthetic pathways.
Axel Soto‐Serrano, Irina Sadovskaya, Evgeny Vinogradov, Wenwen Li, Jun‐Hyeok Yu, Kelsey White, Douwe van Sinderen, Lukasz Krych, Paulina Deptula, Jennifer Mahony   +9 more
wiley   +1 more source

Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs [PDF]

, 2013
Rates of infection with antibiotic-resistant bacteria have increased precipitously over the past several decades, with far-reaching healthcare and societal costs.
Ahmadi, Sara, Dantas, Gautam, Forsberg, Kevin J, Gibson, Molly K, Pehrsson, Erica C   +4 more
core   +2 more sources

Study of the Aminoglycoside Subsistence Phenotype of Bacteria Residing in the Gut of Humans and Zoo Animals [PDF]

, 2016
Recent studies indicate that next to antibiotic resistance, bacteria are able to subsist on antibiotics as a carbon source. Here we evaluated the potential of gut bacteria from healthy human volunteers and zoo animals to subsist on antibiotics.
Gerrit eBor, Hauke eSmidt, Mark W.J. evan Passel, Mark W.J. evan Passel, Teresita De Jesus eBello Gonzalez, Tina eZuidema   +5 more
core   +3 more sources

Genome‐Driven Analysis Reveals the Biotechnological Potential of a Novel Paenibacillus sp. Isolated From Crude Oil

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida, Carlos Miguel Nóbrega Mendonça, Leandro Marcio Moreira, Ricardo Pinheiro de Souza Oliveira, Alessandro de Mello Varani, Mauro de Medeiros Oliveira   +5 more
wiley   +1 more source

The RAGNYA fold: a novel fold with multiple topological variants found in functionally diverse nucleic acid, nucleotide and peptide-binding proteins

Nucleic Acids Research, 2007
Using sensitive structure similarity searches, we identify a shared alpha+beta fold, RAGNYA, principally involved in nucleic acid, nucleotide or peptide interactions in a diverse group of proteins.
S. Balaji, L. Aravind
semanticscholar   +1 more source