Results 51 to 60 of about 6,866 (163)

PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the african trypanosome [PDF]

, 2013
Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and progression of DNA replication.
Aguilera, Aidan J. Doherty, Alsford, Altschul, Brun, Burton, Bétous, Callegari, Callegari, Daigaku, David Horn, Della, di Caprio, Diamant, El-Sayed, Elvers, Frick, Garg, Glover, Glover, Godoy, Heller, Hines, Hines, Hopfner, Iyer, Jansen, Jansen, Jozwiakowski, Karras, Kuchta, Lange, Lao-Sirieix, Lazzaro, Lehmann, Li, Lopes, Lucy Glover, Muzi-Falconi, Passos-Silva, Pitcher, Plosky, Proudfoot, Rastogi, Rey, Rupp, Sale, Sean G. Rudd, Siegel, Stanislaw K. Jozwiakowski, Tiengwe, Tiengwe, Ulrich, van Luenen, Waters, Waters, Woodward   +56 more
core   +4 more sources

Genome‐Driven Analysis Reveals the Biotechnological Potential of a Novel Paenibacillus sp. Isolated From Crude Oil

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida, Carlos Miguel Nóbrega Mendonça, Leandro Marcio Moreira, Ricardo Pinheiro de Souza Oliveira, Alessandro de Mello Varani, Mauro de Medeiros Oliveira   +5 more
wiley   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages [PDF]

, 2018
The first extensively drug resistant (XDR) Neisseria gonorrhoeae strain with high resistance to the extended-spectrum cephalosporin ceftriaxone was identified in 2009 in Japan, but no other strain with this antimicrobial-resistance profile has been ...
Deguchi, Takashi, Didelot, Xavier, Kawahata, Takuya, Kuroki, Toshiro, Lee, Ken-ichi, Morita, Masatomo, Nakayama, Shu-ichi, Ohnishi, Makoto, Ohya, Hitomi, Shimuta, Ken, Watanabe, Yuko, Yahara, Koji, Yasuda, Mitsuru   +12 more
core   +1 more source

Beyond tumour suppression: cGAS‐STING pathway in urologic malignancies: Context‐dependent duality and therapeutic implications

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
The context‐dependent duality of cGAS–STING signalling in urologic tumours is revealed. Targeting the STING pathway, in combination with immunotherapies and gene therapies, enhances the anti‐tumour response. Sex hormone differences in urological malignancies are correlated with the cGAS–STING pathway.
Qi Wei, Kui Zhao, Yifan Wu, Wenhui Wu, Na Hao   +4 more
wiley   +1 more source

Synthesis and repair of 3'-end of tRNA molecule by tRNA nucleotidyltransferase [PDF]

, 2010
Enzim ATP(CTP):tRNA-nukleotidil-transferaza (CCA enzim) katalizira posttranskripcijsku sintezu i popravak slijeda CCA na 3'-kraju molekule tRNA, neophodnog u reakcijama translacije i stoga od životne važnosti za stanicu.
Hajdinjak, Mateja
core   +2 more sources

Unusual tRNA nucleotidyltransferases: Adaptation of the Romanomermis culicivorax CCA-adding enzyme towards armless tRNAs and characterization of the phosphodiesterase domain of the Escherichia coli CCA-adding enzyme [PDF]

, 2022
tRNAs spielen eine zentrale Rolle in jedem bekannten Organismus. Sie agieren als Adaptoren, um den Code der Nukleinsäuren in eine funktionale Aminosäuresequenz zu übersetzen.
Philipp, Susanne
core   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids [PDF]

, 2010
Background p27(Kip1) is a cyclin-dependent kinase inhibitor that inhibits G1-to-S phase transition of the cell cycle. It is known that a relatively large number of nutritional and chemopreventive anti-cancer agents specifically up-regulate expression of ...
Isao Eto
core   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source