Results 91 to 100 of about 894,362 (295)
, 2006 In this chapter, we would like to highlight the possible connections between DNA polymerases, the main enzymes in DNA metabolism, and human diseases, also critically evaluating those cases where the experimental data are not fully convincing. To this aim, we will first give a short overview of the three main DNA metabolic events, namely replication ...
Ramadan, K, Maga, G, Hübscher, U
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Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
The Binding of DNA Polymerase to Polyoma DNA
Journal of General Virology, 1969 Summary DNA polymerase from unpurified extracts of either infected or serumtreated resting mouse embryo cells was bound to double-stranded polyoma DNA and the complex could be separated from the free enzyme and other protein by zone centrifugation through sucrose gradients.
J. D. Pitts, M. Fried
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
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IS DNA POLYMERASE A CYTOPLASMIC ENZYME? [PDF]
, 1962 David M. Prescott +2 more
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
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Two Species of DNA Polymerase Isolated from Escherichia coli [PDF]
, 1967 Axel Lezius +3 more
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DNA polymerases of eukaryotes [PDF]
FEBS Letters, 1975 I.R. Johnston, A.M. Holmes
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Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
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EFFECT OF THE LAMBDA REPRESSOR ON THE BINDING OF RNA POLYMERASE TO DNA [PDF]
, 1969 W S Hayward, Melvin H. Green
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