Results 271 to 280 of about 898,091 (296)
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Biochemical and Biophysical Research Communications, 1971
Summary Homogeneous DNA polymerases from E. coli and sea urchins contain zinc in a proportion of approximately 2 and 4 gm atoms Zn/mole enzyme respectively. Specific inhibition of the enzyme by ortho -phenanthroline and lack of inhibition by meta -phenanthroline suggest that the bound zinc plays a functional role in the interaction of DNA with ...
Albert S. Mildvan +2 more
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Summary Homogeneous DNA polymerases from E. coli and sea urchins contain zinc in a proportion of approximately 2 and 4 gm atoms Zn/mole enzyme respectively. Specific inhibition of the enzyme by ortho -phenanthroline and lack of inhibition by meta -phenanthroline suggest that the bound zinc plays a functional role in the interaction of DNA with ...
Albert S. Mildvan +2 more
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DNA polymerases and carcinogenesis
Biochemistry (Moscow), 2010There are many various chromosomal and gene mutations in human cancer cells. The total mutation rate in normal human cells is 2·10(-7) mutations/gene/division. From 6 to 12 carcinogenic mutations can arise by the end of the life, and these can affect the structure of ~150 protooncogenes and genes encoding suppressors of tumor growth. However, this does
T. P. Kravetskaya, V. M. Krutyakov
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[8] Purification of mammalian DNA polymerases: DNA polymerase α
1995Publisher Summary This chapter discusses the purification of mammalian DNA polymerases, DNA polymerase α. DNA polymerase α plays a key role in the initiation and replication of the mammalian chromosome. The production of a panel of monoclonal antibodies against human DNA polymerase α allowed the development of a three-step immunoaffinity purification
Lars Rogge +3 more
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Current Protocols in Molecular Biology, 2012
AbstractThe DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA polymerase information from public and private records into an open, searchable database. Curr. Protoc. Mol. Biol. 99:3.25.1‐3.25.2. © 2012 by John Wiley & Sons, Inc.
Nicole M. Nichols, Bradley W. Langhorst
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AbstractThe DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA polymerase information from public and private records into an open, searchable database. Curr. Protoc. Mol. Biol. 99:3.25.1‐3.25.2. © 2012 by John Wiley & Sons, Inc.
Nicole M. Nichols, Bradley W. Langhorst
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Annual Review of Biochemistry, 1977
PERSPECTIVES A ND SU MMARY ......... 25 IN TR ODUCTION ........ ... 27 CE LLU LAR DNA POL YMERASES ....... . 28 DNA Polymerase a ......... 28 DNA Polymerase /3 31 DNA Polymerase 'Y •.....• • 33 Mitochondrial DNA Polymerase .... ......... 34 VIR US-INDUCED DNA POL YMERASES ......... ....
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PERSPECTIVES A ND SU MMARY ......... 25 IN TR ODUCTION ........ ... 27 CE LLU LAR DNA POL YMERASES ....... . 28 DNA Polymerase a ......... 28 DNA Polymerase /3 31 DNA Polymerase 'Y •.....• • 33 Mitochondrial DNA Polymerase .... ......... 34 VIR US-INDUCED DNA POL YMERASES ......... ....
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2012
DNA polymerase ε (Pol ε) is one of three replicative DNA polymerases in eukaryotic cells. Pol ε is a multi-subunit DNA polymerase with many functions. For example, recent studies in yeast have suggested that Pol ε is essential during the initiation of DNA replication and also participates during leading strand synthesis.
Erik Johansson, Matthew Hogg
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DNA polymerase ε (Pol ε) is one of three replicative DNA polymerases in eukaryotic cells. Pol ε is a multi-subunit DNA polymerase with many functions. For example, recent studies in yeast have suggested that Pol ε is essential during the initiation of DNA replication and also participates during leading strand synthesis.
Erik Johansson, Matthew Hogg
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Nature, 1970
A membrane associated DNA polymerizing enzyme has been solubilized, partially isolated and characterized.
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A membrane associated DNA polymerizing enzyme has been solubilized, partially isolated and characterized.
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Biochemical and Biophysical Research Communications, 1965
Abstract An experiment will be described which shows that DNA polymerase helps select the base in DNA replication. After elucidating the structure of DNA (1953a), Watson and Crick proposed a template mechanism for the replication of DNA (1953b).
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Abstract An experiment will be described which shows that DNA polymerase helps select the base in DNA replication. After elucidating the structure of DNA (1953a), Watson and Crick proposed a template mechanism for the replication of DNA (1953b).
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2004
Publisher Summary This chapter focuses on DNA polymerases (Pols) and their functions. DNA Pols are central players in DNA repair and replication—the processes that duplicate genomes and maintain their integrity to ensure faithful transmission of genetic information from one generation to other.
Thomas A. Kunkel, Katarzyna Bebenek
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Publisher Summary This chapter focuses on DNA polymerases (Pols) and their functions. DNA Pols are central players in DNA repair and replication—the processes that duplicate genomes and maintain their integrity to ensure faithful transmission of genetic information from one generation to other.
Thomas A. Kunkel, Katarzyna Bebenek
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1996
Publisher Summary This chapter describes DNA polymerases of mesophiles and covers DNA polymerases of thermophilic Eubacteria and Archaea. It covers both thermophiles, organisms that grow optimally in the range of 50–70oC, but not at 90oC, and hyperthermophiles, organisms with an optimal growth temperature of at least 80°C, which also grow at 90°C ...
Huimin Kong +2 more
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Publisher Summary This chapter describes DNA polymerases of mesophiles and covers DNA polymerases of thermophilic Eubacteria and Archaea. It covers both thermophiles, organisms that grow optimally in the range of 50–70oC, but not at 90oC, and hyperthermophiles, organisms with an optimal growth temperature of at least 80°C, which also grow at 90°C ...
Huimin Kong +2 more
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