Results 101 to 110 of about 900,531 (345)
Stress-induced duplex destabilization (SIDD) profiles for T7 bacteriophage promoters [PDF]
Компьютерные исследования и моделирование, 2018 The functioning of DNA regulatory regions rely primarily on their physicochemical and structural properties but not on nucleotide sequences, i.e. genetic text.
Mikhail Anatolievich Orlov +4 more
doaj +1 more source
A design proposal of the reverse DNA polymerase (3'-5' direction) [PDF]
arXiv, 2013 DNA Polymerase is an enzyme that participates in the process of DNA replication. In general, forward DNA polymerase moves along the template strand in a 3'-5' direction, and the daughter strand is formed in a 5'-3' direction. This paper theoretically analyzes the mechanism of forward DNA polymerase, and gives the design proposal of a new reverse DNA ...
arxiv
The interaction of RNA polymerase II with non-promoter DNA sites [PDF]
Nucleic Acids Research, 1981 Various complexes formed between purified RNA polymerase II and simian virus 40 DNA have been characterized with respect to rates of formation, rates of dissociation, and initial velocity of RNA synthesis. Two different types of complexes can form on intact DNA templates. One of these is formed rapidly, but is quite labile; the other forms more slowly,
D.Walt Chandler, Jay D. Gralla
openaire +3 more sources
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Electrostatic map of T7 DNA. Comparative analysis of functional and electrostatic properties of T7 RNA polymerase specific promoters [PDF]
, 2013 The entire T7 bacteriophage genome contains 39937 base pairs (Database NCBI RefSeq N1001604). Here, electrostatic potential distribution around double helical T7 DNA was calculated by Coulomb method using the computer program of Sorokin A.A. Electrostatic profiles of 17 promoters recognized by T7 phage specific RNA polymerase were analyzed.
arxiv +1 more source
Bayesian inference of polymerase dynamics over the exclusion process [PDF]
arXiv, 2021 Transcription is a complex phenomenon that permits the conversion of genetic information into phenotype by means of an enzyme called RNA polymerase, which erratically moves along and scans the DNA template. We perform Bayesian inference over a paradigmatic mechanistic model of non-equilibrium statistical physics, i.e., the asymmetric exclusion ...
arxiv
Nature Genetics, 2019 It is not clear how spontaneous DNA double-strand breaks (DSBs) form and are processed in normal cells, and whether they predispose to cancer-associated translocations.
G. Dellino +16 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
A critical survey on the kinetic assays of DNA polymerase fidelity from a new theoretical perspective [PDF]
arXiv, 2020 The high fidelity of DNA polymerase is critical for the faithful replication of genomic DNA. Several approaches were proposed to quantify the fidelity of DNA polymerase. Direct measurements of the error frequency of the replication products definitely give the true fidelity but turn out very hard to implement.
arxiv
Structural features of DNA that determine RNA polymerase II core promoter [PDF]
BMC Genomics, 2016 The general structure and action of all eukaryotic and archaeal RNA polymerases machinery have an astonishing similarity despite the diversity of core promoter sequences in different species. The goal of our work is to find common characteristics of DNA region that define it as a promoter for the RNA polymerase II (Pol II).The profiles of a large ...
Maria Poptsova +5 more
openaire +3 more sources