Results 151 to 160 of about 1,237,824 (318)

Terminal deoxynucleotidyltransferase. Serological studies and radioimmunoassay [PDF]

, 1976
Mouse antisera against calf terminal deoxynucleotidyltransferase (terminal transferase) have been prepared. The sera have been used to characterize terminal transferase both by studying inhibition of enzyme activity and by developing a competition ...
Baltimore, David, Gottlieb, Paul D., Kung, Patrick C.   +2 more
core  

A phenotype for enigmatic DNA polymerase II: a pivotal role for pol II in replication restart in UV-irradiated Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America, 1999
S. Rangarajan, R. Woodgate, M. Goodman
semanticscholar   +1 more source

Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair

Nature Structural & Molecular Biology
During transcription-coupled DNA repair (TCR), RNA polymerase II (Pol II) transitions from a transcriptionally active state to an arrested state that allows for removal of DNA lesions.
G. Kokic, George Yakoub, D. van den Heuvel, Annelotte P. Wondergem, Paula J. van der Meer, Yana van der Weegen, A. Chernev, Isaac Fianu, Thornton J. Fokkens, Sonja Lorenz, H. Urlaub, Patrick Cramer, M. S. Luijsterburg   +12 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Isolation and partial characterization of a mutant of Escherichia coli deficient in DNA polymerase II.

Proceedings of the National Academy of Sciences of the United States of America, 1972
J. Campbell, L. Soll, C. Richardson
semanticscholar   +1 more source

Mechanism of translesion DNA synthesis by DNA polymerase II. Comparison to DNA polymerases I and III core.

The Journal of biological chemistry, 1996
Bypass synthesis by DNA polymerase II was studied using a synthetic 40-nucleotide-long gapped duplex DNA containing a site-specific abasic site analog, as a model system for mutagenesis associated with DNA lesions. Bypass synthesis involved a rapid polymerization step terminating opposite the nucleotide preceding the lesion, followed by a slow bypass ...
T, Paz-Elizur, M, Takeshita, M, Goodman, M, O'Donnell, Z, Livneh   +4 more
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

DNA Gene’s Basic Structure as a Nonperturbative Circuit Quantum Electrodynamics: Is RNA Polymerase II the Quantum Bus of Transcription?

Current Issues in Molecular Biology
Previously, we described that Adenine, Thymine, Cytosine, and Guanine nucleobases were superconductors in a quantum superposition of phases on each side of the central hydrogen bond acting as a Josephson Junction.
Raul Riera Aroche, Yveth M. Ortiz García, Esli C. Sánchez Moreno, José S. Enriquez Cervantes, Andrea C. Machado Sulbaran, Annie Riera Leal   +5 more
doaj   +1 more source

Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae.

Nucleic Acids Research, 1991
H. Araki, R. K. Hamatake, A. Morrison, A. Johnson, Leland H. Johnston, Akio Sugino   +5 more
semanticscholar   +1 more source

Analysis of the Essential Functions of the C-terminal Protein/Protein Interaction Domain of Saccharomyces cerevisiae pol epsilon and Its Unexpected Ability to Support Growth in the Absence of the DNA Polymerase Domain [PDF]

, 1999
As first observed by Wittenberg (Kesti, T., Flick, K., Keranen, S., Syvaoja, J. E., and Wittenburg, C. (1999) Mol. Cell 3, 679-685), we find that deletion mutants lacking the entire N-terminal DNA polymerase domain of yeast pol epsilon are viable ...
Campbell, Judith L., Dua, Rajiv, Levy, Daniel L.   +2 more
core