Results 181 to 190 of about 900,531 (345)

Human papillomavirus (HPV) prediction for oropharyngeal cancer based on CT by using off‐the‐shelf features: A dual‐dataset study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background This study aims to develop a novel predictive model for determining human papillomavirus (HPV) presence in oropharyngeal cancer using computed tomography (CT). Current image‐based HPV prediction methods are hindered by high computational demands or suboptimal performance.
Junhua Chen, Yanyan Cheng, Lijun Chen, Banghua Yang   +3 more
wiley   +1 more source

Distinct molecular structures of nuclear class I, II, and III DNA-dependent RNA polymerases.

, 1975
Virgil E. F. Sklar, Lawrence B. Schwartz, Robert G. Roeder   +2 more
openalex   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Rapid Enhancement of Chick Intestinal DNA-Dependent RNA Polymerase II Activity by 1α,25-Dihydroxyvitamin D ₃ , In Vivo

, 1974
Joseph E. Zerwekh, Mark R. Haussler, Thomas J. Lindell   +2 more
openalex   +1 more source

Sequence‐dependent Termination of Mammalian DNA Polymerase Reaction by a New Platinum Compound, (–)‐(R)‐2‐Aminomethylpyrrolidine(1,1‐cyclobutane‐dicarboxylato)‐2‐platinum(II) Monohydrate [PDF]

, 1991
Mitsumasa Iwata, Shunji Izuta, Motoshi Suzuki, Kiyohide Kojima, Yoshihito Furuhashi, Yutaka Tomoda, Shonen Yoshida   +6 more
openalex   +1 more source

RNA Polymerase II is a Polar Roadblock to a Progressing DNA Fork

DNA replication and transcription occur simultaneously on the same DNA template, leading to inevitable conflicts between the replisome and RNA polymerase. These conflicts can stall the replication fork and threaten genome stability. Although numerous studies show that head-on conflicts are more detrimental and more prone to promoting R-loop formation ...
Taryn M. Kay, James T. Inman, Lucyna Lubkowska, Tung T. Le, Jin Qian, Porter M. Hall, Dong Wang, Mikhail Kashlev, Michelle D. Wang   +8 more
openaire   +2 more sources

FGF14 GAA Intronic Expansion in Unsolved Adult‐Onset Ataxia in the Care4Rare Canada Consortium

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Spinocerebellar ataxias (SCA) represent a clinically and genetically heterogeneous group of progressive neurodegenerative diseases with prominent cerebellar atrophy. Recently, a novel pathogenic repeat expansion in intron 1 of FGF14 was identified, causing adult‐onset SCA (SCA27B). We aimed to determine the proportion
Alexanne Cuillerier, Giulia F. Del Gobbo, Layla Mackay, Erika Wall, Madeline Couse, Laura M. McDonell, Mireille Cloutier, Matt C. Danzi, Jodi Warman‐Chardon, Pierre R. Bourque, Oksana Suchowersky, Alan Mears, Luke Seldenthuis, Wendy Mears, Laura Larrigan, Alexandre White‐Brown, Gerald Pfeffer, Dennis E. Bulman, David Dyment, Care4Rare Canada Consortium, Kym M. Boycott   +20 more
wiley   +1 more source

Elucidation of the role of stress-induced DNA polymerase II in the pathogenesis of uropathogenic Escherichia coli

International Journal of Infectious Diseases
Introduction: Uropathogenic Escherichia coli (UPEC) strains are responsible for most registered urinary tract infections (UTIs) in humans. Invading bacteria are exposed to harsh conditions resulting from the host's attempts to inactivate them ...
Dr Damian Gawel, M.Sc. Anna Betkowska, MD Marcin Rozwadowski, Dr Marlena Godlewska, Prof Roel Schaaper   +4 more
doaj  

Peptide maps comparing subunits of maize chloroplast and type II nuclear DNA-dependent RNA polymerases.

, 1979
G. Kidd, Lawrence Bogorad
openalex   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source