Results 11 to 20 of about 1,237,824 (318)
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation [PDF]
eLife, 2019 RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated by proteins with intrinsically disordered regions.
David Trombley McSwiggen +9 more
doaj +3 more sources
Nature Communications, 2022 Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that modulates target gene expression in response to changes in oxygen availability. Here the authors show that HIF-1 forms a complex with TRIM28 and DNA-dependent protein kinase (DNA-PK) that ...
Yongkang Yang +5 more
doaj +2 more sources
Mechanism of Translesion DNA Synthesis by DNA Polymerase II [PDF]
Journal of Biological Chemistry, 1996 Bypass synthesis by DNA polymerase II was studied using a synthetic 40-nucleotide-long gapped duplex DNA containing a site-specific abasic site analog, as a model system for mutagenesis associated with DNA lesions.
T. Paz-Elizur +4 more
semanticscholar +2 more sources
Somatic mutations in angiogenesis-related pathways and RNA polymerase II activity in sporadic brain arteriovenous malformations [PDF]
Frontiers in NeurologyBackgroundSporadic brain arteriovenous malformations (bAVMs) are rare vascular anomalies characterized by abnormal angiogenesis and direct arteriovenous shunting.
Rebeca Pérez-Alfayate +7 more
doaj +2 more sources
RNA polymerase II is a polar roadblock to a progressing DNA fork [PDF]
Nature CommunicationsTranscription–replication conflicts threaten genome stability. Although head-on conflicts are more detrimental and prone to R-loop formation than co-directional conflicts, the cause of this RNA polymerase roadblock polarity remains unclear, and proposed ...
Taryn M. Kay +10 more
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The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
Nature Communications, 2020 The response to DNA damage-stalled RNA polymerase II leads to the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. Here, the authors reveal the complex assembly mechanism of the TCR complex in human cells.
Yana van der Weegen +11 more
doaj +2 more sources
Genome Biology, 2018 Background Alternative DNA secondary structures can arise from single-stranded DNA when duplex DNA is unwound during DNA processes such as transcription, resulting in the regulation or perturbation of these processes. We identify sites of high propensity
Karol Szlachta +5 more
doaj +2 more sources
Molecular mechanism of co-transcriptional H3K36 methylation by SETD2 [PDF]
Nature CommunicationsH3K36me3 is a hallmark of actively and recently transcribed genes and contributes to cellular memory and identity. The deposition of H3K36me3 occurs co-transcriptionally when the methyltransferase SETD2 associates with RNA polymerase II.
James L. Walshe +8 more
doaj +2 more sources
Mechanism of RNA polymerase II stalling by DNA alkylation
Proceedings of the National Academy of Sciences, 2017 Significance RNA polymerase II (Pol II) catalyzes the transcription of DNA to RNA in the nucleus. DNA alkylating cancer drugs can stall transcription; however, the basis for Pol II stalling when encountering a DNA template with minor-groove alkylation ...
S. Malvezzi +5 more
semanticscholar +7 more sources
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins.
Journal of Biological Chemistry, 1992 An interesting property of the Escherichia coli DNA polymerase II is the stimulation in DNA synthesis mediated by the DNA polymerase III accessory proteins beta,gamma complex. In this paper we have studied the basis for the stimulation in pol II activity and have concluded that these accessory proteins stimulate pol II activity by increasing the ...
Cynthia A. BonnerS +8 more
semanticscholar +3 more sources