Results 11 to 20 of about 812,933 (320)

Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. [PDF]

PLoS ONE, 2008
A relationship exists between nuclear architecture and gene activity and it has been proposed that the activity of ongoing RNA polymerase II transcription determines genome organization in the mammalian cell nucleus.
Robert-Jan Palstra, Marieke Simonis, Petra Klous, Emilie Brasset, Bart Eijkelkamp, Wouter de Laat   +5 more
doaj   +3 more sources

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

Nature Communications, 2020
The response to DNA damage-stalled RNA polymerase II leads to the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. Here, the authors reveal the complex assembly mechanism of the TCR complex in human cells.
Yana van der Weegen, Hadar Golan-Berman, Tycho E. T. Mevissen, Katja Apelt, Román González-Prieto, Joachim Goedhart, Elisheva E. Heilbrun, Alfred C. O. Vertegaal, Diana van den Heuvel, Johannes C. Walter, Sheera Adar, Martijn S. Luijsterburg   +11 more
doaj   +2 more sources

Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human

Genome Biology, 2018
Background Alternative DNA secondary structures can arise from single-stranded DNA when duplex DNA is unwound during DNA processes such as transcription, resulting in the regulation or perturbation of these processes. We identify sites of high propensity
Karol Szlachta, Ryan G. Thys, Naomi D. Atkin, Levi C. T. Pierce, Stefan Bekiranov, Yuh-Hwa Wang   +5 more
doaj   +2 more sources

DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae.

The EMBO Journal, 1992
Two temperature-sensitive DNA polymerase II mutants (pol2-9 and pol2-18) of the yeast Saccharomyces cerevisiae were isolated by the plasmid shuffling method. DNA polymerase II activity partially purified from both mutants was thermolabile, while DNA polymerase I and III activities remained thermotolerant.
H. Araki, P. Ropp, A. Johnson, Leland H. Johnston, A. Morrison, Akio Sugino   +5 more
semanticscholar   +4 more sources

DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America, 1990
C A Bonner, Sharon L. Hays, Kathleen Mc Entee, Myron F. Goodman   +3 more
openalex   +2 more sources

DNA-directed termination of RNA polymerase II transcription [PDF]

Molecular Cell, 2023
RNA polymerase II (RNAPII) transcription involves initiation from a promoter, transcriptional elongation through the gene, and termination in the terminator region. In bacteria, terminators often contain specific DNA elements provoking polymerase dissociation, but RNAPII transcription termination is thought to be driven entirely by protein co-factors ...
Zhong Han, George A. Moore, Richard Mitter, David Lopez Martinez, Li Wan, A. Barbara Dirac Svejstrup, David S. Rueda, Jesper Q. Svejstrup   +7 more
openaire   +3 more sources

Structure of an Intranucleosomal DNA Loop That Senses DNA Damage during Transcription

Cells, 2022
Transcription through chromatin by RNA polymerase II (Pol II) is accompanied by the formation of small intranucleosomal DNA loops containing the enzyme (i-loops) that are involved in survival of core histones on the DNA and arrest of Pol II during the ...
Nadezhda S. Gerasimova, Olesya I. Volokh, Nikolay A. Pestov, Grigory A. Armeev, Mikhail P. Kirpichnikov, Alexey K. Shaytan, Olga S. Sokolova, Vasily M. Studitsky   +7 more
doaj   +1 more source

Transcription shapes DNA replication initiation to preserve genome integrity

Genome Biology, 2021
Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu, Chen Ai, Tingting Gan, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao, Qing Li, Xiong Ji, Jiazhi Hu   +10 more
doaj   +1 more source

DNA photodamage recognition by RNA polymerase II [PDF]

FEBS Letters, 2007
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo‐lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in ...
Brückner, F., Cramer, P.
openaire   +3 more sources

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II

Nature Communications, 2022
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn   +12 more
doaj   +1 more source