Results 11 to 20 of about 1,237,675 (182)

Transcription Factor Binding to Replicated DNA

open access: yesCell Reports, 2020
Summary: Genome replication perturbs the DNA regulatory environment by displacing DNA-bound proteins, replacing nucleosomes, and introducing dosage imbalance between regions replicating at different S-phase stages.
Raz Bar-Ziv   +3 more
doaj   +1 more source

Structure of the p53/RNA polymerase II assembly

open access: yesCommunications Biology, 2021
Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II ...
Shu-Hao Liou   +4 more
doaj   +1 more source

Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. [PDF]

open access: yesPLoS ONE, 2008
A relationship exists between nuclear architecture and gene activity and it has been proposed that the activity of ongoing RNA polymerase II transcription determines genome organization in the mammalian cell nucleus.
Robert-Jan Palstra   +5 more
doaj   +1 more source

Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair

open access: yesNature Communications, 2021
Here the authors provide models of RNA polymerase II bound to the yeast CSB ortholog Rad26 in different nucleotide states; explain how Rad26 domain motions help the polymerase progress past DNA lesions; and interpret the effects of CSB-associated disease
Chunli Yan   +7 more
doaj   +1 more source

Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage [PDF]

open access: yes, 2017
The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells.
Boros, I.M. (Imre M.)   +7 more
core   +7 more sources

The menin tumor suppressor protein is phosphorylated in response to DNA damage. [PDF]

open access: yesPLoS ONE, 2011
Multiple endocrine neoplasia type 1 (MEN1) is a heritable cancer syndrome characterized by tumors of the pituitary, pancreas and parathyroid. Menin, the product of the MEN1 gene, is a tumor suppressor protein that functions in part through the regulation
Joshua Francis   +3 more
doaj   +1 more source

Structural Transition of the Nucleosome during Transcription Elongation

open access: yesCells, 2023
In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai   +3 more
doaj   +1 more source

Characterization of RNA polymerases from Rous sarcoma virus-induced mouse ascites sarcoma cells. [PDF]

open access: yes, 1979
RNA polymerase was extracted from the Schmidt-Ruppin strain of Rous sarcoma virus (SR-RSV)-induced C3H/He mouse ascites sarcoma cells (SR-C3H). RNA polymerase was separated into RNA polymerases I and II by DEAE-Sephadex chromatography.
Misumi, Hiromasa, Oda, Takuzo
core   +1 more source

A comparative study of DNA-dependent RNA polymerases from rat ascites hepatoma cell nuclei and from rat liver nuclei [PDF]

open access: yes, 1975
DNA-dependent RNA polymerases (EC 2.7.7.6) were extracted and partially purified form the nuclei of rat ascites hepatoma cells (AH-130) induced by 4-dimethylaminoazobenzene.
Misumi, Hiromasa
core   +1 more source

Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription

open access: yesNature Communications, 2023
NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nuclear functions
Ália dos Santos   +18 more
doaj   +1 more source

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