Results 21 to 30 of about 900,531 (345)

Mechanism of RNA polymerase II stalling by DNA alkylation [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance RNA polymerase II (Pol II) catalyzes the transcription of DNA to RNA in the nucleus. DNA alkylating cancer drugs can stall transcription; however, the basis for Pol II stalling when encountering a DNA template with minor-groove alkylation adducts has remained elusive due to its inherent chemical instability.
Malvezzi, Stefano, Farnung, Lucas, Aloisi, Claudia M. N., Angelov, Todor, Cramer, Patrick, Sturla, Shana J.   +5 more
openaire   +6 more sources

Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair

Nature Communications, 2021
Here the authors provide models of RNA polymerase II bound to the yeast CSB ortholog Rad26 in different nucleotide states; explain how Rad26 domain motions help the polymerase progress past DNA lesions; and interpret the effects of CSB-associated disease
Chunli Yan, Thomas Dodd, Jina Yu, Bernice Leung, Jun Xu, Juntaek Oh, Dong Wang, Ivaylo Ivanov   +7 more
doaj   +1 more source

Structural Transition of the Nucleosome during Transcription Elongation

Cells, 2023
In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during ...
Tomoya Kujirai, Haruhiko Ehara, Shun-ichi Sekine, Hitoshi Kurumizaka   +3 more
doaj   +1 more source

DNA polymerase II fromEscherichia coli [PDF]

, 1996
C. R. A. Muchmore, M. M. Blair, L. Shuvalova, M.F. Goodman, W.F. Anderson   +4 more
openalex   +2 more sources

The menin tumor suppressor protein is phosphorylated in response to DNA damage. [PDF]

PLoS ONE, 2011
Multiple endocrine neoplasia type 1 (MEN1) is a heritable cancer syndrome characterized by tumors of the pituitary, pancreas and parathyroid. Menin, the product of the MEN1 gene, is a tumor suppressor protein that functions in part through the regulation
Joshua Francis, Wenchu Lin, Orit Rozenblatt-Rosen, Matthew Meyerson   +3 more
doaj   +1 more source

Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription

Nature Communications, 2023
NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in the nucleus and is expressed throughout the cell, to date, there is no clear nuclear functions
Ália dos Santos, Daniel E. Rollins, Yukti Hari-Gupta, Hannah McArthur, Mingxue Du, Sabrina Yong Zi Ru, Kseniia Pidlisna, Ane Stranger, Faeeza Lorgat, Danielle Lambert, Ian Brown, Kevin Howland, Jesse Aaron, Lin Wang, Peter J. I. Ellis, Teng-Leong Chew, Marisa Martin-Fernandez, Alice L. B. Pyne, Christopher P. Toseland   +18 more
doaj   +1 more source

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.

Proceedings of the National Academy of Sciences of the United States of America, 1995
DPB11, a gene that suppresses mutations in two essential subunits of Saccharomyces cerevisiae DNA polymerase II(epsilon) encoded by POL2 and DPB2, was isolated on a multicopy plasmid.
H. Araki, S. Leem, A. Phongdara, Akio Sugino   +3 more
semanticscholar   +1 more source

SnapShot: DNA Polymerases II Mammals

Cell, 2010
DNA polymerases ensure the faithful duplication of genetic information inside the nuclease and mitochondria of eukaryotic cells and the nucleoid of prokaryotic cells. These remarkable enzymes synthesize polynucleotide chains based on the complementarity of an incoming nucleotide to an existing DNA template. DNA polymerases are grouped into six families
Foti, James J., Walker, Graham C.
openaire   +4 more sources

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy.

PLoS ONE, 2014
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit ...
Jitka Holcakova, Petr Muller, Peter Tomasec, Roman Hrstka, Marta Nekulova, Vladimir Krystof, Miroslav Strnad, Gavin W G Wilkinson, Borivoj Vojtesek   +8 more
doaj   +1 more source

Selective RNA Labeling by RNA-Compatible Type II Restriction Endonuclease and RNA-Extending DNA Polymerase

Life, 2022
RNAs not only offer valuable information regarding our bodies but also regulate cellular functions, allowing for their specific manipulations to be extensively explored for many different biological and clinical applications.
Hyesung Jo, Jiyun Beon, Seung Soo Oh
doaj   +1 more source