Results 301 to 310 of about 1,237,824 (318)
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Template properties of human dna‐dependent rna polymerase II
Medical and Pediatric Oncology, 1976AbstractDNA‐dependent RNA polymerase II has been purified from lymphocytes of patients with chronic lymphocytic leukemia (CLL). Form II polymerase and Escherichia coli RNA polymerase have been used to study the transcription of human DNA and chromatin. The hybridization kinetics of the transcripts of DNA and chromatin by the human polymerase are quite ...
H D, Garcia, M J, Tsai, G F, Saunders
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SOS-inducible DNA polymerase II of E coli is homologous to replicative DNA polymerase of eukaryotes
Biochimie, 1991The polB gene of Escherichia coli encodes DNA polymerase II whose role in vivo is not defined. The polB gene has been cloned and shown to be identical to a DNA damage-inducible gene dinA which is regulated by the LexA repressor. Nucleotide sequencing of polB reveals that E coli DNA polymerase II is highly homologous to replicative DNA polymerases of ...
Shinagawa, H. +3 more
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Structural homology between DNA binding sites of DNA polymerase β and DNA topoisomerase II
Journal of Molecular Biology, 2000Unsaturated long-chain fatty acids selectively bind to the DNA binding sites of DNA polymerase beta and DNA topoisomerase II, and inhibit their activities, although the amino acid sequences of these enzymes are markedly different from each other. Computer modeling analysis revealed that the fatty acid interaction interface in both enzymes has a group ...
Y, Mizushina +3 more
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Escherichia coli DNA Polymerases II and III
1974When cells of an E. coli mutant (pol Al−)1 which is deficient in DNA polymerase I (pol I) are lysed in a French pressure cell, they yield a cell-free extract with a small but demonstrable amount of DNA polymerizing activity.2 Following the removal of nucleic acid from such an extract, phosphocellulose chromatography can resolve two separate DNA ...
Thomas Kornberg +2 more
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DNA structure in human RNA polymerase II promoters.
Journal of molecular biology, 1998The fact that DNA three-dimensional structure is important for transcriptional regulation begs the question of whether eukaryotic promoters contain general structural features independently of what genes they control. We present an analysis of a large set of human RNA polymerase II promoters with a very low level of sequence similarity.
A G, Pedersen +3 more
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Transcription of methylated viral DNA by eukaryotic RNA polymerase II
Cell Biophysics, 1989The genome of the large icosahedral DNA virus, frog virus 3 (FV3), is heavily methylated at the cytosine residues of dCdG dinucleotide pairs, with more than 22% of the total cytosine residues in the form of 5-methylcytosine (5mC). This methylation is carried out postreplicatively in the cytoplasm of infected cells by a virus-encoded DNA ...
D B, Willis +3 more
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Euglena gracilis DNA dependent RNA polymerase II: a zinc metalloenzyme
Biochemistry, 1976Zinc is essential for cellular proliferation. Zinc deficiency of Euglena gracilis results in arrest of cell division and deranges nucleic acid and protein metabolism pointing to a decisive role of zinc in transcription and translation. We have, therefore, investigated the role of zinc in the function of the DNA-dependent RNA polymerases of this ...
K H, Falchuk +3 more
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DNA Polymerase II-Dependent DNA Synthesis in Toluenized Bacillus subtilis Cells
1975An ATP-dependent DNA-polymerase-II-mediated repair can be demonstrated in Bacillus subtilis toluenized cells using 6-(p-hydroxyphenylazo)uracil (HPUra) and exogenous DNase I.
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ATP-independent, DNA synthesis by DNA polymerase II in toluenized Bacillus subtilis
Biochemical and Biophysical Research Communications, 1974Phleomycin stimulates ATP-independent DNA repair synthesis by polymerase II in toluenized B. subtilis cells. In the presence of ATP it also increases the synthesis, with BrdUTP, of DNA with a density between that of normal DNA and hybrid DNA, and it enhances replicative DNA synthesis by polymerase III.
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DNA-dependent DNA polymerases from HeLa cell nuclei II. Template and substrate utilization
Biochemical and Biophysical Research Communications, 1971Abstract Two separable DNA polymerases which have been partially purified from the nuclei of HeLa cells prefer as primer a double-stranded DNA into which 3′-hydroxyl termini have been introduced by nuclease action. These enzymes differ in their ability to use synthetic polydeoxynucleotides as templates.
A, Schlabach +3 more
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