Results 51 to 60 of about 812,933 (320)
Transcription Blockage Leads to New Beginnings
Biomolecules, 2015 Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed?
Leonardo C. Andrade-Lima +2 more
doaj +1 more source
Escherichia coli DNA polymerase II catalyzes chromosomal and episomal DNA synthesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 1997 We have investigated a role for Escherichia coli DNA polymerase II (Pol II) in copying chromosomal and episomal DNA in dividing cells in vivo. Forward mutation frequencies and rates were measured at two chromosomal loci, rpoB and gyrA, and base ...
S. Rangarajan +4 more
semanticscholar +1 more source
Cell Reports, 2016 Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116).
Zachary C. Poss +9 more
doaj +1 more source
Journal of Biological Chemistry, 1995 Wild-type DNA polymerase II (pol II) and an exonuclease-deficient pol II mutant (D155A/E157A) have been overexpressed and purified in high yield from Escherichia coli.
Hong Cai +4 more
semanticscholar +1 more source
Diversity of Akanthomyces on moths (Lepidoptera) in Thailand [PDF]
MycoKeys, 2020 Akanthomyces is a genus of invertebrate-pathogenic fungi from the family Cordycipitaceae (Ascomycota, Hypocreales). Its species occurs on two different types of hosts, spiders and insects, and in the latter case specifically Lepidoptera adults. Three new
Arifah Nur Aini +5 more
doaj +3 more sources
Journal of Biological Chemistry, 1998 Two forms of DNA polymerase II (ε) ofSaccharomyces cerevisiae, Pol II* and Pol II, were purified to near homogeneity from yeast cells. Pol II* is a four-subunit complex containing a 256-kDa catalytic polypeptide, whereas Pol II consists solely of a 145 ...
S. Maki +3 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
PLoS Genetics, 2019 Repetitive DNA sequences within eukaryotic heterochromatin are poorly transcribed and replicate late in S-phase. In Saccharomyces cerevisiae, the histone deacetylase Sir2 is required for both transcriptional silencing and late replication at the ...
Eric J Foss +7 more
doaj +1 more source
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation
eLife, 2019 RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated by proteins with intrinsically disordered regions.
David Trombley McSwiggen +9 more
doaj +1 more source
Nucleic Acids Research, 1999 Pyrococcus furiosus has an operon containing the DNA polymerase II (PolD) gene and three other genes. Using a two-hybrid screening to examine the interactions of the proteins encoded by the operon, we identified a specific interaction between the second ...
I. Hayashi, K. Morikawa, Y. Ishino
semanticscholar +1 more source