Results 61 to 70 of about 900,531 (345)
Monofunctional DNA-platinum(II) adducts block frequently DNA polymerases
Nucleic Acids Research, 1992 The question of whether monofunctional DNA platinum(II) adducts block synthesis of DNA by purified DNA polymerases of different types and origin has been investigated by comparing the time dependence of synthesis arrest and of DNA adduct formation.
Reinhard Bauer +2 more
openaire +4 more sources
A mutant of Escherichia coli defective in DNA polymerase II activity.
Proceedings of the National Academy of Sciences of the United States of America, 1972 A mutant of E. coli defective in DNA polymerase II activity was isolated. Extracts had about 0.1% of the normal activity of the DNA polymerase. The effect of the mutation on the ability of cells to replicate DNA of various sources was analyzed.
Y. Hirota, M. Gefter, L. Mindich
semanticscholar +1 more source
Transcription Factor Binding to Replicated DNA
Cell Reports, 2020 Summary: Genome replication perturbs the DNA regulatory environment by displacing DNA-bound proteins, replacing nucleosomes, and introducing dosage imbalance between regions replicating at different S-phase stages.
Raz Bar-Ziv +3 more
doaj
Transcription Blockage Leads to New Beginnings
Biomolecules, 2015 Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed?
Leonardo C. Andrade-Lima +2 more
doaj +1 more source
Escherichia coli DNA polymerase II catalyzes chromosomal and episomal DNA synthesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 1997 We have investigated a role for Escherichia coli DNA polymerase II (Pol II) in copying chromosomal and episomal DNA in dividing cells in vivo. Forward mutation frequencies and rates were measured at two chromosomal loci, rpoB and gyrA, and base ...
S. Rangarajan +4 more
semanticscholar +1 more source
Journal of Biological Chemistry, 1995 Wild-type DNA polymerase II (pol II) and an exonuclease-deficient pol II mutant (D155A/E157A) have been overexpressed and purified in high yield from Escherichia coli.
Hong Cai +4 more
semanticscholar +1 more source
All-or-none switching of transcriptional activity on single DNA molecules caused by a discrete conformational transition [PDF]
, 2004 Recently, it has been confirmed that long duplex DNA molecules with sizes larger than several tens of kilo-base pairs (kbp), exhibit a discrete conformational transition from an elongated coil state to a compact globule state upon the addition of various kinds of chemical species that usually induce DNA condensation.
arxiv +1 more source
Cell Reports, 2016 Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116).
Zachary C. Poss +9 more
doaj +1 more source
Diversity of Akanthomyces on moths (Lepidoptera) in Thailand [PDF]
MycoKeys, 2020 Akanthomyces is a genus of invertebrate-pathogenic fungi from the family Cordycipitaceae (Ascomycota, Hypocreales). Its species occurs on two different types of hosts, spiders and insects, and in the latter case specifically Lepidoptera adults. Three new
Arifah Nur Aini +5 more
doaj +3 more sources
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation
eLife, 2019 RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated by proteins with intrinsically disordered regions.
David Trombley McSwiggen +9 more
doaj +1 more source