Monoclonal antibodies as probes for a function of large T antigen during the elongation process of simian virus 40 DNA replication [PDF]
, 1987 Maria Wiekowski, Peter Dröge, H. Stahl
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Molecular Beacon DNA Probes with Fluorescein Bifluorophore. [PDF]
Russ J Bioorg Chem, 2021 Brylev VA +6 more
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Complementary DNA probes for the Duchenne muscular dystrophy locus demonstrate a previously undetectable deletion in a patient with dystrophic myopathy, glycerol kinase deficiency, and congenital adrenal hypoplasia. [PDF]
, 1989 Edward R.B. McCabe +8 more
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Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Modular fluorescent nanoparticle DNA probes for detection of peptides and proteins. [PDF]
Sci Rep, 2021 Stawicki CM +8 more
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DNA probes for identification of clinically important Bacteroides species [PDF]
, 1986 A P Kuritza +4 more
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Chemical probes of DNA structure in chromatin
Chemistry & Biology, 1995 Understanding the way genes work requires detailed knowledge of the organization of DNA in the chromatin complex. The difficulties associated with the study of this large macromolecular assembly present an interesting challenge to both biologists and chemists.
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Programming Fluorogenic DNA Probes for Rapid Detection of Steroids. [PDF]
Angew Chem Int Ed Engl, 2021 Ebrahimi SB +8 more
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