Results 81 to 90 of about 3,751,417 (261)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast [PDF]

, 2008
The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes.
Leonid Brodsky, Yefim Ronin, Abraham Korol, Eviatar Nevo, Aviv de Morgan, Yechezkel Kashi   +5 more
core  

Cells expressing murine RAD52 splice variants favor sister chromatid repair [PDF]

, 2006
The RAD52 gene is essential for homologous recombination in the yeast Saccharomyces cerevisiae. RAD52 is the archetype in an epistasis group of genes essential for DNA damage repair.
Freeman, TC, Savitzky, MH, Sunjevaric, [No Value], Rothstein, R, Marrero, VA, Thorpe, PH   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

DNA REPAIR

, 2014
The human genome, comprises about three billion base pairs coding for 40 000–50 000 genes and is constantly attacked byReactive metabolites, drugs and a environmental mutagens that affects its integrity. Thus it is obvious that continuous surveillance is
Ramya Chellammal Muthusamy, Saveetha Dental College, Tamil Nadu   +2 more
core  

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA [PDF]

, 2011
How tightly packed chromatin is thoroughly inspected for DNA damage is one of the fundamental unanswered questions in biology. In particular, the effective excision of carcinogenic lesions caused by the ultraviolet (UV) radiation of sunlight depends on ...
Naegeli, H, Nina Kaczmarek, Andreas Glas, Glas, Andreas, Carell Thomas, Glas, A, Carell, Thomas, Fei Jia, Kaczmarek Nina, Glas Andreas, Jia Fei, Carell, T, Andreas Luch, Naegeli Hanspeter, Fei, Jia, Naegeli, Hanspeter, Luch Andreas, Kaczmarek, Nina, Thomas Carell, Hanspeter Naegeli, Luch, A, Luch, Andreas, Fei, J, Kaczmarek, N, Luch, A., Fei, J., Carell, T., Kaczmarek, N., Glas, A., Naegeli, H., Carell T, Fei J, Glas A, Luch A, Naegeli H, Kaczmarek N   +35 more
core   +2 more sources

The methyltransferase N6amt1 regulates hippocampal neurogenesis through 6 mA modification of Txnrd3 DNA

Cellular and Molecular Life Sciences
N6-methyladenine (6 mA), the most prevalent DNA modification in mammals and other eukaryotes, regulates DNA mismatch repair, chromosome replication, and transcription. However, its role in adult hippocampal neurogenesis remains unkown.
Yuanfei Wu, Wenhui Ma, Qingqing Li, Yang Li, Linjie Xie, Xuejian Kong, Shuwei Chen, Qian Wang, Aiguo Xuan   +8 more
doaj   +1 more source

Natural Course of Neonatal Progeroid Syndrome

Pediatrics and Neonatology, 2009
Several progeroid disorders presenting a specific “old-man” appearance since birth or childhood have been described. Here, five patients with a history of severe intrauterine and postnatal growth retardation and pseudohydrocephaloid cranium noted after ...
Jia-Woei Hou
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

, 2021
Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in ...
Theodoros I. Roumeliotis (1725436), Geneviève Almouzni (14952607), Jessica A. Downs (14952613), Sophie Postel-Vinay (14946771), Suzanna R. Hopkins (14952583), Clémence Hénon (14952589), Raphaël Margueron (14952604), Asha Konde (1808494), Eric Deutsch (14952610), Christophe Massard (14952598), Thomas Eychenne (14952565), Jean-Charles Soria (66947), Stephen J. Pettitt (14952601), Léo Colmet-Daage (14952568), Nicolas Dorvault (3585098), Roman M. Chabanon (14952562), Christopher J. Lord (14952616), Cornelia Meisenberg (14952574), Elaine Del Nery (310455), Carine Ngo (14952580), Jyoti S. Choudhary (9927836), Marlène Garrido (14952571), Samuel Jouny (14952586), Andrew Lamb (14952577), Ilirjana Bajrami (407000), Clémence Astier (14952595), Asuka Kawai-Kawachi (14952592), Daphné Morel (5330492)   +27 more
core   +1 more source