Results 1 to 10 of about 6,825 (112)

Inborn Errors of Immunity and Cancer

Biology, 2021
Inborn Errors of Immunity (IEI) are a heterogeneous group of disorders characterized by a defect in the function of at least one, and often more, components of the immune system.
Alessandra Tiri, Riccardo Masetti, Francesca Conti, Anna Tignanelli, Elena Turrini, Patrizia Bertolini, Susanna Esposito, Andrea Pession   +7 more
doaj   +3 more sources

Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases

Journal of Fungi, 2023
Inborn errors of immunity are a heterogeneous group of genetically determined disorders that compromise the immune system, predisposing patients to infections, autoinflammatory/autoimmunity syndromes, atopy/allergies, lymphoproliferative disorders, and ...
Peter Olbrich, Donald C. Vinh
doaj   +3 more sources

Treosulfan-based conditioning for inborn errors of immunity

Therapeutic Advances in Hematology, 2021
Inborn errors of immunity (IEI) are inherited disorders that lead to defects in the development and/or function of the immune system. The number of disorders that can be treated by haematopoietic stem-cell transplantation (HSCT) has increased rapidly ...
Mary A. Slatter, Andrew R. Gennery
doaj   +2 more sources

Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response [PDF]

Human Vaccines & Immunotherapeutics
Individuals with inborn errors of immunity often mount suboptimal responses to vaccination, yet the molecular determinants underlying their variable responses to mRNA vaccines remain poorly defined.
Paolo Palma, Elena Emili, Chiara Pighi, Nicole Colantoni, Elena Morrocchi, Giuseppe Rubens Pascucci, Beatrice Rivalta, Gioacchino Andrea Rotulo, Chiara Rossetti, Veronica Santilli, Paola Zangari, Emma Concetta Manno, Marco Sanna, Andrea Finocchi, Caterina Cancrini, Maria Pia Cicalese, Sabina Cenciarelli, Emilia Cirillo, Giuliana Giardino, Viviana Moschese, Donato Amodio, Nicola Cotugno   +21 more
doaj   +2 more sources

IKZF-associated inborn errors of immunityIKZF-associated inborn errors of immunity [PDF]

Journal of Human Immunity
Germline variants in IKZF family proteins cause inborn errors of immunity characterized by variable degrees of immunodeficiency, immune dysregulation, and occasional malignancies.
Motoi Yamashita, Tomohiro Morio
doaj   +2 more sources

Inborn Errors of Immunity: how to diagnose them?

Jornal de Pediatria, 2021
Objectives: Inborn Errors of Immunity are characterized by infectious conditions and manifestations of immune dysregulation. The diversity of clinical phenotypes can make it difficult to direct the laboratory investigation.
Anete Sevciovic Grumach, Ekaterini Simões Goudouris   +1 more
doaj   +3 more sources

Thrombocytopenia in patients with inborn errors of immunity [PDF]

BMC Immunology
Background Inborn errors of immunity (IEI) are inherited defects of innate or adaptive immune system. Thrombocytopenia is a significant multifactorial complication in IEI patients leading to severe clinical consequences including coagulative disorders ...
Saba Fekrvand, Maryam Mohtashami, Negin Sanadgol, Helia Salehi, Najmeh Nameh Goshay Fard, Ehsan Khoshnezhad Afkham, Zahra Chavoshzadeh, Nima Parvaneh, Seyed Alireza Mahdaviani, Samin Sharafian, Sahar Barzamini, Hamid Ahanchian, Arash Kalantari, Alireza Shafiei, Marzieh Tavakol, Farhad Abolnezhadian, Mina Kianmanesh Rad, Gholamreza Hassanpour, Taher Cheraghi, Amir Salehi Farid, Samaneh Delavari, Hassan Abolhassani, Nima Rezaei, Reza Yazdani   +23 more
doaj   +2 more sources

An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants

Scientific Reports, 2021
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that competes with endogenous ACE2 for binding of the ...
Shiho Tanaka, Gard Nelson, C. Anders Olson, Oleksandr Buzko, Wendy Higashide, Annie Shin, Marcos Gonzalez, Justin Taft, Roosheel Patel, Sofija Buta, Ashley Richardson, Dusan Bogunovic, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, Patrick Soon-Shiong   +15 more
doaj   +1 more source

Failure of immunological competence: when to suspect?

Jornal de Pediatria, 2021
Objectives: To draw physicians’ attention to the different warning signs of diseases of inborn errors of immunity. Data sources: A non-systematic review of the literature was carried out in the PubMed, LILACS, and SciELO databases, in addition to ...
Fernanda Pinto-Mariz
doaj   +1 more source

Endocrinopathies in Inborn Errors of Immunity

Frontiers in Immunology, 2021
Inborn errors of immunity (IEI), caused by hereditary or genetic defects, are a group of more than 400 disorders, in which the immune system, including lymphocytes, neutrophils, macrophages, and complements, does not function properly.
Kei Takasawa, Hirokazu Kanegane, Kenichi Kashimada, Tomohiro Morio   +3 more
doaj   +1 more source