Results 31 to 40 of about 7,759 (229)

An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants

Scientific Reports, 2021
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that competes with endogenous ACE2 for binding of the ...
Shiho Tanaka, Gard Nelson, C. Anders Olson, Oleksandr Buzko, Wendy Higashide, Annie Shin, Marcos Gonzalez, Justin Taft, Roosheel Patel, Sofija Buta, Ashley Richardson, Dusan Bogunovic, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, Patrick Soon-Shiong   +15 more
doaj   +1 more source

Thrombocytopenia in patients with inborn errors of immunity

BMC Immunology
Background Inborn errors of immunity (IEI) are inherited defects of innate or adaptive immune system. Thrombocytopenia is a significant multifactorial complication in IEI patients leading to severe clinical consequences including coagulative disorders ...
Saba Fekrvand, Maryam Mohtashami, Negin Sanadgol, Helia Salehi, Najmeh Nameh Goshay Fard, Ehsan Khoshnezhad Afkham, Zahra Chavoshzadeh, Nima Parvaneh, Seyed Alireza Mahdaviani, Samin Sharafian, Sahar Barzamini, Hamid Ahanchian, Arash Kalantari, Alireza Shafiei, Marzieh Tavakol, Farhad Abolnezhadian, Mina Kianmanesh Rad, Gholamreza Hassanpour, Taher Cheraghi, Amir Salehi Farid, Samaneh Delavari, Hassan Abolhassani, Nima Rezaei, Reza Yazdani   +23 more
doaj   +3 more sources

Failure of immunological competence: when to suspect?

Jornal de Pediatria, 2021
Objectives: To draw physicians’ attention to the different warning signs of diseases of inborn errors of immunity. Data sources: A non-systematic review of the literature was carried out in the PubMed, LILACS, and SciELO databases, in addition to ...
Fernanda Pinto-Mariz
doaj   +1 more source

Nature and nurture: understanding phenotypic variation in inborn errors of immunity

Frontiers in Cellular and Infection Microbiology, 2023
The overall disease burden of pediatric infection is high, with widely varying clinical outcomes including death. Among the most vulnerable children, those with inborn errors of immunity, reduced penetrance and variable expressivity are common but poorly
Morgan Similuk, Taco Kuijpers
doaj   +1 more source

Monogenic Adult-Onset Inborn Errors of Immunity

Frontiers in Immunology, 2021
Inborn errors of immunity (IEI) are a heterogenous group of disorders driven by genetic defects that functionally impact the development and/or function of the innate and/or adaptive immune system.
Frederik Staels, Frederik Staels, Tom Collignon, Albrecht Betrains, Albrecht Betrains, Margaux Gerbaux, Margaux Gerbaux, Mathijs Willemsen, Mathijs Willemsen, Stephanie Humblet-Baron, Adrian Liston, Adrian Liston, Steven Vanderschueren, Steven Vanderschueren, Rik Schrijvers, Rik Schrijvers   +15 more
doaj   +1 more source

RIPK1-Associated Inborn Errors of Innate Immunity

Frontiers in Immunology, 2021
RIPK1 (receptor-interacting serine/threonine-protein kinase 1) is a key molecule for mediating apoptosis, necroptosis, and inflammatory pathways downstream of death receptors (DRs) and pattern recognition receptors (PRRs).
Jiahui Zhang, Jiahui Zhang, Taijie Jin, Taijie Jin, Ivona Aksentijevich, Qing Zhou, Qing Zhou   +6 more
doaj   +1 more source

Disseminated mycobacterial infections after tumor necrosis factor inhibitor use, revealing inborn errors of immunity

International Journal of Infectious Diseases, 2023
Tumor necrosis factor-a inhibitors can be associated with increased risk of infections, particularly reactivation of latent tuberculosis or nontuberculous mycobacterium (NTM). However, because disseminated NTM is rare, inborn errors of immunity should be
Jacqueline D. Squire, Claudia R. Libertin, Harry Powers, Jared Nelson, Lisa Brumble, Federico R. Laham, Anahita Agharahimi, Alexandra F. Freeman, Jennifer W. Leiding   +8 more
doaj   +1 more source

Liver immunity, autoimmunity, and inborn errors of immunity

World Journal of Hepatology, 2023
The liver is the front line organ of the immune system. The liver contains the largest collection of phagocytic cells in the body that detect both pathogens that enter through the gut and endogenously produced antigens. This is possible by the highly developed differentiation capacity of the liver immune system between self-antigens or non-self ...
ÇAĞDAŞ AYVAZ, DENİZ NAZİRE, AYAR, ŞEFİKA NUR, PARLAR, YAVUZ EMRE, BALABAN, HATİCE YASEMİN   +3 more
openaire   +3 more sources

Visceral Leishmaniasis Revealing Undiagnosed Inborn Errors of Immunity

Revista da Sociedade Brasileira de Medicina Tropical, 2023
Visceral Leishmaniasis (VL) is a potentially fatal disease and may be associated with primary or acquired immunodeficiencies. There are few reports, in the literature, of inborn errors of immunity.
Daniel Gleison Carvalho, Dewton de Moraes Vasconcelos, Andreia Cristiane Rangel Santos, Jose Angelo Lauletta Lindoso   +3 more
doaj   +1 more source

Adenosine deaminase type 2 deficiency: From rare to commonUpdate on human adenosine deaminase 2 deficiency [PDF]

Journal of Human Immunity
Wouters et al. review the clinical and genetic landscape of DADA2, a multisystem inborn error of immunity. It examines expanding phenotypes, emerging pathophysiological mechanisms, treatment strategies, and newly described dominant-negative variants that
Marjon Wouters, Verena Kienapfel, Lisa Ehlers, Hasan Hashem, Ivona Aksentijevich, Isabelle Meyts   +5 more
doaj   +1 more source