Results 21 to 30 of about 165,980,093 (264)
Inborn Errors of Immunity With Immune Dysregulation: From Bench to Bedside
Frontiers in Pediatrics, 2019 Inborn errors of immunity are genetic disorders with broad clinical manifestations, ranging from increased susceptibility to infections to significant immune dysregulation, often leading to multiple autoimmune phenomena, lymphoproliferation, and ...
Ottavia Maria Delmonte +5 more
doaj +2 more sources
Editorial: Inborn errors of immunity and mucosal immunity
Frontiers in Immunology, 2023 Elena Wen-Yuan Hsieh +3 more
doaj +3 more sources
Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response [PDF]
Human Vaccines & ImmunotherapeuticsIndividuals with inborn errors of immunity often mount suboptimal responses to vaccination, yet the molecular determinants underlying their variable responses to mRNA vaccines remain poorly defined.
Paolo Palma +21 more
doaj +2 more sources
Deciphering the clinical and genetic spectrum of early-onset inborn errors of immunity in a Brazilian pediatric cohort [PDF]
Frontiers in ImmunologyInborn errors of immunity are a heterogeneous group of rare genetic disorders associated with susceptibility to infections, autoimmunity, allergy, and malignancy. Owing to marked clinical variability, phenotypic overlap, and limited access to specialized
Luiza de Mattos +22 more
doaj +2 more sources
Functional genomics in inborn errors of immunity
Immunological ReviewsSummaryInborn errors of immunity (IEI) comprise a diverse spectrum of 485 disorders as recognized by the International Union of Immunological Societies Committee on Inborn Error of Immunity in 2022. While IEI are monogenic by definition, they illuminate various pathways involved in the pathogenesis of polygenic immune dysregulation as in autoimmune or ...
Charlotte Hurabielle +3 more
openaire +4 more sources
Human inborn errors of immunity: diagnosis and management [PDF]
Exploration of ImmunologyPrimary immunodeficiency disease (PID) now known as inborn errors of immunity (IEI) is genetic disorder(s) that impair the immune system. IEI is a heterogeneous group of diseases of more than 485 lifelong genetic disorders mainly due to intrinsic defect ...
Iftekhar Mahmood
doaj +3 more sources
Current genetic diagnostics in inborn errors of immunity
Frontiers in PediatricsNew technologies in genetic diagnostics have revolutionized the understanding and management of rare diseases. This review highlights the significant advances and latest developments in genetic diagnostics in inborn errors of immunity (IEI), which ...
Doris Steinemann +2 more
exaly +3 more sources
Inborn Errors of Immunity: New Insights
Acta Medica AcademicaThis paper presents a comprehensive and updated overview of inborn errors of immunity (IEIs), focusing on the optimal treatment strategies. IEIs or primary immunodeficiencies (PIDs) are a heterogeneous group of approximately 500 disorders, classified into ten categories according to the affected component of the immune system. The clinical presentation
Roganović, Jelena, Bellesi, Gaia
openaire +4 more sources
Editorial: Immune dysregulation in inborn errors of immunity
Frontiers in Pediatrics, 2023 Eveline Y. Wu +3 more
doaj +3 more sources
An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
Scientific Reports, 2021 The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that competes with endogenous ACE2 for binding of the ...
Shiho Tanaka +15 more
doaj +1 more source