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Primary immunodeficiency [PDF]

Allergy, Asthma & Clinical Immunology, 2018
Primary immunodeficiency disorder (PID) refers to a large heterogeneous group of disorders that result from defects in immune system development and/or function.
Christine McCusker, Julia Upton, Richard Warrington   +2 more
doaj   +5 more sources

Primary immunodeficiency [PDF]

Allergy, Asthma & Clinical Immunology, 2011
Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function.
McCusker Christine, Warrington Richard
doaj   +3 more sources

Early-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromes [PDF]

Scientific Reports, 2017
Syndromic primary immunodeficiencies are rare genetic disorders that affect both the immune system and other organ systems. More often, the immune defect is not the major clinical problem and is sometimes only recognized after a diagnosis has been made ...
Delfien J. Bogaert, Melissa Dullaers, Hye Sun Kuehn, Bart P. Leroy, Julie E. Niemela, Hans De Wilde, Sarah De Schryver, Marieke De Bruyne, Frauke Coppieters, Bart N. Lambrecht, Frans De Baets, Sergio D. Rosenzweig, Elfride De Baere, Filomeen Haerynck   +13 more
doaj   +3 more sources

Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]

, 2009
Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Silke Schüle, Björn-Philipp Kloke, Julia K. Kaiser, Sabine Heidmeier, Sylvia Panitz, Nina Wolfrum, Klaus Cichutek, Matthias Schweizer, Reuben S. Harris, S Neil, S Sonza, MD Mühlebach, S Sonza, K Triques, G Peng, V Arfi, YL Chiu, PJ Ellery, M Pion, N Wolfrum, TM Fletcher 3rd, C Goujon, C Goujon, R Sleigh, S Mahalingam, LA Mahnke, HA Pancio, H Schuitemaker, T Kino, P Di Marzio, L Selig, L Jarrosson-Wuilleme, JA Poole, VM Hirsch, JA LaBonte, K Lee, B Song, M Stremlau, R Mariani, G Brennan, A Gruber, PH Tan, M Belshan, PK Singhal, C Goujon, N Sharova, C Dong, LY Liou, G Peng, Y Iwatani, JC Kappes, G Berger, R Sakuma, R Sakuma, M Stremlau, J Shi, E Sokolskaja, PK Singhal, R Sakuma, L Naldini, PM Strappe, DS Ory   +61 more
core   +10 more sources

Impact of Primary Immunodeficiency Diseases on the Life Experiences of Patients in Malaysia From the Caregivers’ Perspective: A Qualitative Study

Frontiers in Pediatrics, 2022
IntroductionPrimary immunodeficiency diseases (PIDs) are chronic diseases that affect the various aspects of a patient’s life. However, the impact of living with PIDs is poorly described.ObjectiveThis study aimed to explore the living experience ...
Ruwaydah Ahmed Meelad, Intan Juliana Abd Hamid, Ilie Fadzilah Hashim, Zarina Thasneem Zainudeen, Firdaus Farhani Abu Bakar, Fahisham Taib, Norsarwany Mohamad, Ernest Mangantig, Intan Hakimah Ismail, Amir Hamzah Abdul Latiff, Lokman Mohd Noh   +10 more
doaj   +1 more source

Impact of IL-15 and latency reversing agent combinations in the reactivation and NK cell-mediated suppression of the HIV reservoir

Scientific Reports, 2022
Inhibitors of histone deacetylases (HDACis) are major latency reversing agent (LRA) candidates in ‘shock and kill’ strategies to eradicate the HIV reservoir in infected patients.
Daniela Angela Covino, Maria Giovanna Desimio, Margherita Doria   +2 more
doaj   +1 more source

Psychosocial impact of COVID-19 pandemic on Malaysian families: a cross-sectional study

BMJ Open, 2021
Objective To investigate the psychosocial impact of COVID-19 on Malaysian families.Design A cross-sectional study performed using an anonymous online questionnaire distributed through social media, email and the Department of Social Welfare.Setting ...
Zarina Thasneem Zainudeen, Intan Juliana Abd Hamid, Muhd Nur Akmal Azizuddin, Firdaus Farhani Abu Bakar, Salina Sany, Izzal Asnira Zolkepli, Ernest Mangantig   +6 more
doaj   +1 more source

Case Report: Eosinophilic Esophagitis in a Patient With a Novel STAT1 Gain-of-Function Pathogenic Variant

Frontiers in Immunology, 2022
BackgroundSTAT1 gain-of-function (GOF) is a primary immune dysregulatory disorder marked by wide infectious predisposition (most notably chronic mucocutaneous Candidiasis), autoimmunity, vascular disease and malignant predisposition.
Ori Scott, Nigel Sharfe, Nigel Sharfe, Harjit Dadi, Harjit Dadi, Linda Vong, Linda Vong, Jenny Garkaby, Laura Abrego Fuentes, Jessica Willett Pachul, Sandra Nelles, Amit Nahum, Amit Nahum, Chaim M. Roifman, Chaim M. Roifman   +14 more
doaj   +1 more source

Systematic Review of Primary Immunodeficiency Diseases in Malaysia: 1979–2020

Frontiers in Immunology, 2020
Introduction: Primary immunodeficiency diseases (PIDs) are under-reported in Malaysia. The actual disease frequency of PID in this country is unknown due to the absence of a national patient registry for PID.Objective: This systematic review aimed to ...
Intan Juliana Abd Hamid, Nur Adila Azman, Andrew R. Gennery, Ernest Mangantig, Ilie Fadzilah Hashim, Zarina Thasneem Zainudeen   +5 more
doaj   +1 more source

Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic

Frontiers in Pediatrics, 2023
BackgroundInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is clinically diverse, and children have a low risk of developing severe coronavirus disease 2019 (COVID-19). However, children with chronic diseases have a potentially
Levi Hoste, Levi Hoste, Agnieszka Prytula, Jo Dehoorne, Ruth De Bruyne, Stephanie Van Biervliet, Kathleen De Waele, Evelyn Maes, Victoria Bordon, Arnaud Vanlander, Karlien Claes, Johan Vande Walle, Petra Schelstraete, Sabine Van daele, Filomeen Haerynck, Filomeen Haerynck   +15 more
doaj   +1 more source