Results 21 to 30 of about 495,905 (303)

Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic

Frontiers in Pediatrics, 2023
BackgroundInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is clinically diverse, and children have a low risk of developing severe coronavirus disease 2019 (COVID-19). However, children with chronic diseases have a potentially
Levi Hoste, Levi Hoste, Agnieszka Prytula, Jo Dehoorne, Ruth De Bruyne, Stephanie Van Biervliet, Kathleen De Waele, Evelyn Maes, Victoria Bordon, Arnaud Vanlander, Karlien Claes, Johan Vande Walle, Petra Schelstraete, Sabine Van daele, Filomeen Haerynck, Filomeen Haerynck   +15 more
doaj   +1 more source

A case of acanthosis nigricans in a HIV-infected patient [PDF]

, 2020
Background: To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1).
De Vincentiis, Ludovica, Di Paolo, Marcello, Iacovelli, Alessandra, Mezzaroma, Ivano, Palange, Paolo, Soda, Giuseppe   +5 more
core   +1 more source

Update in Primary Immunodeficiencies.

Acta bio-medica : Atenei Parmensis, 2020
Primary immunodeficiencies (PIDs) are inherited disorders classically characterized by increased susceptibility to infections. Nevertheless, in the last two decades, genomic analysis (such as NGS) coupled with biochemical and cellular studies led to a more accurate definition for a growing number of novel genetic disorders associated with PIDs.
Leonardi, Lucia, Rivalta, Beatrice, Cancrini, Caterina, Chiappini, Elena, Cravidi, Claudio, Caffarelli, Carlo, Manti, Sara, Calvani, Mauro, Martelli, Alberto, Miraglia Del Giudice, Michele, Duse, Marzia, Marseglia, Gian Luigi, Cardinale, Fabio   +12 more
openaire   +4 more sources

PI3Kδ and primary immunodeficiencies [PDF]

Nature Reviews Immunology, 2016
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (which encodes p110δ) and PIK3R1 (which encodes p85α) that cause a ...
Lucas, Carrie L, Chandra, Anita, Nejentsev, Sergey, Condliffe, Alison M, Okkenhaug, Klaus   +4 more
openaire   +2 more sources

Homozygous duplication identified by whole genome sequencing causes LRBA deficiency

npj Genomic Medicine, 2021
In more than one-third of primary immunodeficiency (PID) patients, extensive genetic analysis including whole-exome sequencing (WES) fails to identify the genetic defect.
Daniele Merico, Yehonatan Pasternak, Mehdi Zarrei, Edward J. Higginbotham, Bhooma Thiruvahindrapuram, Ori Scott, Jessica Willett-Pachul, Eyal Grunebaum, Julia Upton, Adelle Atkinson, Vy H. D. Kim, Elbay Aliyev, Khalid Fakhro, Stephen W. Scherer, Chaim M. Roifman   +14 more
doaj   +1 more source

Evaluation of Humoral and Cellular Responses in SARS-CoV-2 mRNA Vaccinated Immunocompromised Patients

Frontiers in Immunology, 2022
BackgroundImmunocompromised patients are at increased risk of severe COVID-19 and impaired vaccine response. In this observational prospective study, we evaluated immunogenicity of the BNT162b2 mRNA vaccine in cohorts of primary or secondary ...
Matthijs Oyaert, Marie-Angélique De Scheerder, Sophie Van Herrewege, Guy Laureys, Sofie Van Assche, Melissa Cambron, Leslie Naesens, Leslie Naesens, Levi Hoste, Levi Hoste, Karlien Claes, Karlien Claes, Filomeen Haerynck, Filomeen Haerynck, Tessa Kerre, Steven Van Laecke, Wim Van Biesen, Peggy Jacques, Bruno Verhasselt, Elizaveta Padalko   +19 more
doaj   +1 more source

Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans

Immunity & Ageing, 2018
Background Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged ...
Sudhir Gupta, Houfen Su, Sudhanshu Agrawal, Sastry Gollapudi   +3 more
doaj   +1 more source

Neutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env [PDF]

, 2010
Neutralising antibodies (NAbs) play a vital role in vaccine-induced protection against infection with feline immunodeficiency virus (FIV). However, little is known about the appropriate presentation of neutralisation epitopes in order to induce NAbs ...
Hosie, Margaret J., Ishida, Takuo, Logan, Nicola, McMonagle, Elizabeth L., Mochizuki, Masami, Samman, Ayman, Willett, Brian J.   +6 more
core   +1 more source

Consanguinity and Primary Immunodeficiencies [PDF]

Human Heredity, 2014
Primary immunodeficiencies (PIDs) are a heterogeneous group of genetic disorders caused by defects in the immune system that predispose patients to infections, autoimmune diseases, lymphoproliferation and malignancies. Most PIDs are inherited in an autosomal recessive pattern; therefore, they are more common in areas with high rates of consanguineous ...
Waleed, Al-Herz, Hasan, Aldhekri, Mohamed-Ridha, Barbouche, Nima, Rezaei   +3 more
openaire   +2 more sources

Case Report: Association between cyclic neutropenia and SRP54 deficiency

Frontiers in Immunology, 2022
Autosomal dominant mutations in the signal recognition particle (SRP) 54 gene were recently described in patients with severe congenital neutropenia (SCN).
Melinda Erdős, Melinda Erdős, Oksana Boyarchuk, László Maródi, László Maródi   +4 more
doaj   +1 more source