Results 21 to 30 of about 4,729,170 (302)

Consanguinity and Primary Immunodeficiencies [PDF]

Human Heredity, 2014
Primary immunodeficiencies (PIDs) are a heterogeneous group of genetic disorders caused by defects in the immune system that predispose patients to infections, autoimmune diseases, lymphoproliferation and malignancies. Most PIDs are inherited in an autosomal recessive pattern; therefore, they are more common in areas with high rates of consanguineous ...
Waleed, Al-Herz, Hasan, Aldhekri, Mohamed-Ridha, Barbouche, Nima, Rezaei   +3 more
openaire   +2 more sources

Primary immunodeficiency and the microbiome

Current Opinion in Pediatrics, 2021
Purpose of review The current understanding of the relationship of the microbiota to clinical manifestation in patients with primary immunodeficiency, specifically the inflammatory processes caused by or that result in microbial dysbiosis, and their potential therapeutic options in primary immunodeficiency diseases (PID), is ...
Maryam Ali, Al-Nesf, David, Morgan, Vidya, Mohamed-Ali   +2 more
openaire   +2 more sources

The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus [PDF]

, 1999
Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting ...
Hosie, M.J., Willett, B.J., Margaret J. Hosie, Brian J. Willett,   +3 more
core   +1 more source

Case Report: Association between cyclic neutropenia and SRP54 deficiency

Frontiers in Immunology, 2022
Autosomal dominant mutations in the signal recognition particle (SRP) 54 gene were recently described in patients with severe congenital neutropenia (SCN).
Melinda Erdős, Melinda Erdős, Oksana Boyarchuk, László Maródi, László Maródi   +4 more
doaj   +1 more source

Screening of functional and positional candidate genes in families with common variable immunodeficiency [PDF]

, 2008
Background: Common variable immunodeficiency (CVID) comprises a heterogeneous group of primary antibody deficiencies with complex clinical and immunological phenotypes.
Grimbacher, B, Thiel, J, Jung, J, Webster, A. David B., Webster, D, Schäffer, Alejandro A., Pan Hammarström, Q, Lougaris, V, Hammarström, L, Salzer, U, Hagena, Tina, Grimbacher, B., Jung, Johannes, Woellner, Cristina, MOSCHESE, VIVIANA, Schaffer, AA, Webster, DA, Birmelin, J, Pan-Hammarström, Qiang, Du, Likun, Schäffer, A, Birmelin, Jennifer, Woellner, C, Neumann, C, Salzer, Ulrich, Metin, A, Lougaris, Vassilios, Plebani, Alessandro, Hagena, T, Grimbacher, Bodo, Pan-Hammarstrom, Q, Du, L, Thiel, Jens, Hammarström, Lennart, Moschese, V, Hammarstroo, L, Metin, Ayse, Plebani, A, Neumann, Carla   +38 more
core   +1 more source

A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction [PDF]

, 2008
Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry.
Margaret J Hosie, Ayman Samman, Willett Brian J, Samman, Ayman, Logan Nicola, Brian J Willett, Samman Ayman, McMonagle, Elizabeth L., Hosie Margaret J, Logan, Nicola, McMonagle Elizabeth L, Nicola Logan, Hosie, Margaret J., Willett, Brian J., Elizabeth L McMonagle   +14 more
core   +1 more source

Selective IgM Deficiency—An Underestimated Primary Immunodeficiency

Frontiers in Immunology, 2017
Although selective IgM deficiency (SIGMD) was described almost five decades ago, it was largely ignored as a primary immunodeficiency. SIGMD is defined as serum IgM levels below two SD of mean with normal serum IgG and IgA.
Sudhir Gupta, Ankmalika Gupta
doaj   +1 more source

Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Hosie, M.J., Willett, B.J., Cannon, C.A.
core   +1 more source

Evaluation of Humoral and Cellular Immune Responses to the SARS-CoV-2 Vaccine in Patients With Common Variable Immunodeficiency Phenotype and Patient Receiving B-Cell Depletion Therapy

Frontiers in Immunology, 2022
IntroductionSARS-CoV-2 vaccines’ effectiveness is not yet clearly known in immunocompromised patients. This study aims to assess the humoral and cellular specific immune response to SARS-CoV-2 vaccines and the predictors of poor response in patients with
Arnau Antolí, Arnau Antolí, Arnau Antolí, Gemma Rocamora-Blanch, Gemma Rocamora-Blanch, Gemma Rocamora-Blanch, Mario Framil, Mario Framil, Mario Framil, Virgínia Mas-Bosch, Virgínia Mas-Bosch, Virgínia Mas-Bosch, Sergio Navarro, Sergio Navarro, Sergio Navarro, Carla Bermudez, Carla Bermudez, Sergio Martinez-Yelamos, Sergio Martinez-Yelamos, Sergio Martinez-Yelamos, Eva Dopico, Eva Dopico, Laura Calatayud, Laura Calatayud, Laura Calatayud, Nadia Garcia-Muñoz, Luis Humberto Hernández-Benítez, Antoni Riera-Mestre, Antoni Riera-Mestre, Antoni Riera-Mestre, Jordi Bas, Jordi Bas, Jordi Bas, Cristina Masuet-Aumatell, Cristina Masuet-Aumatell, Cristina Masuet-Aumatell, Raúl Rigo-Bonnin, Raúl Rigo-Bonnin, Francisco Morandeira, Francisco Morandeira, Francisco Morandeira, Xavier Solanich, Xavier Solanich, Xavier Solanich   +43 more
doaj   +1 more source

Primary Immunodeficiencies [PDF]

Mayo Clinic Proceedings, 1998
The primary immunodeficiencies are congenital disorders that affect the function of the immune system. The result is an inadequate immune response to microorganisms, self-antigens, and tumor cells, which leads to increased susceptibility to infections, autoimmunity, or malignant disease.
openaire   +2 more sources