An updated review on phenocopies of primary immunodeficiency diseases [PDF]
Genes and Diseases, 2020 Primary immunodeficiency diseases (PIDs) refer to a heterogenous group of disorders characterized clinically by increased susceptibility to infections, autoimmunity and increased risk of malignancies.These group of disorders present with clinical ...
Ankita Singh +4 more
doaj +6 more sources
Reversion Mosaicism in Primary Immunodeficiency Diseases [PDF]
Frontiers in Immunology, 2021 Reversion mosaicism has been reported in an increasing number of genetic disorders including primary immunodeficiency diseases. Several mechanisms can mediate somatic reversion of inherited mutations.
Hanae Miyazawa, Taizo Wada
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Current status and prospects of primary immunodeficiency diseases in Asia [PDF]
Genes and Diseases, 2020 Primary Immunodeficiency Diseases (PIDs) are increasingly being reported across the World. Several advances have been made in the diagnostic and therapeutic research related to PIDs.
Rakesh Kumar Pilania +2 more
exaly +3 more sources
Gene therapy and genome editing for primary immunodeficiency diseases [PDF]
Genes and Diseases, 2020 In past two decades the gene therapy using genetic modified autologous hematopoietic stem cells (HSCs) transduced with the viral vector has become a promising alternative option for treating primary immunodeficiency diseases (PIDs).
Zhi-Yong Zhang +2 more
doaj +3 more sources
Primary Immunodeficiency Diseases: Current and Emerging Therapeutics [PDF]
Frontiers in Immunology, 2017 Primary immunodeficiency diseases (PID) result from defects in genes affecting the immune and other systems in many and varied ways (1, 2). Until the last few years, treatments have been largely supportive, with the exception of bone marrow ...
Beatriz E. Marciano, Steven M. Holland
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CUTANEOUS MANIFESTATIONS OF PRIMARY IMMUNODEFICIENCY DISEASES IN TUNISIAN CHILDREN [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2018 . Skin manifestations are frequent among patients with primary immunodeficiency diseases (PIDs). Their prevalence varies according to the type of immunodeficiency.
Naouel GUIRAT +8 more
doaj +3 more sources
A clinician's guide for administration of high-concentration and facilitated subcutaneous immunoglobulin replacement therapy in patients with primary immunodeficiency diseases. [PDF]
Allergy Asthma Clin Immunol, 2022 Immunoglobulin replacement therapy is the standard-of-care treatment for patients with primary immunodeficiency diseases who have impaired antibody production and function.
Epland K, Suez D, Paris K.
europepmc +2 more sources
Primary immunodeficiency diseases in the newborn. [PDF]
North Clin Istanb, 2021 The normal neonate's immune system is anatomically completed but antigenically inexperienced and shows somewhat decreased role of a number of immunological pathways. Aside from anatomic characteristics (e.g., thin skin and mucosal barriers) of newborn, weakened pro-inflammatory and T-helper cell type 1 cytokine release and lessened cell-mediated ...
Ozdemir O.
europepmc +3 more sources
Impact of Primary Immunodeficiency Diseases on the Life Experiences of Patients in Malaysia From the Caregivers’ Perspective: A Qualitative Study [PDF]
Frontiers in Pediatrics, 2022 IntroductionPrimary immunodeficiency diseases (PIDs) are chronic diseases that affect the various aspects of a patient’s life. However, the impact of living with PIDs is poorly described.ObjectiveThis study aimed to explore the living experience ...
Ruwaydah Ahmed Meelad +10 more
doaj +2 more sources
Gene Editing for the Treatment of Primary Immunodeficiency Diseases. [PDF]
Hum Gene Ther, 2021 With conventional treatments for primary immunodeficiency diseases (PIDs), such as allogeneic stem cell transplantation or autologous gene therapy, still facing important challenges, the rapid development of genome editing technologies to more accurately
Rai R, Thrasher AJ, Cavazza A.
europepmc +2 more sources