Results 41 to 50 of about 4,729,170 (302)

Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point. [PDF]

, 2008
It is unknown whether patterns of human immunodeficiency virus (HIV)-specific T-cell responses during acute infection may influence the viral set point and the course of disease. We wished to establish whether the magnitude and breadth of HIV type 1 (HIV-
Gray, Clive M, van Loggerenberg, Francois, Mlotshwa, Mandla., Mathebula, Tiyani, Seoighe, Cathal., Morris, Lynn, Ngandu, Nobubelo K., Morris, Lynn., Mlisana, Koleka Patience., CAPRISA 002 Acute Infection Study Team, Gray, Clive M., Mlisana, Koleka, Riou, Catherine, Abdool Karim, Salim Safurdeen., Williamson, Carolyn., Mathebula, Tiyani., de Assis Rosa, Debra, Seoighe, Cathal, Mashishi, Tumelo., Mashishi, Tumelo, Williamson, Carolyn, Karim, Salim Abdool, de Assis Rosa, Debra., Ngandu, Nobubelo, Riou, Catherine., van Loggerenberg, Francois., Mlotshwa, Mandla   +26 more
core   +1 more source

Neutropenia in primary immunodeficiency [PDF]

Current Opinion in Hematology, 2013
Neutropenia is a feature of several primary immunodeficiency diseases (PIDDs). Because of the diverse pathophysiologies of the PIDDs and the rarity of each disorder, data are often lacking, leading to the necessity of empiric treatment. Recent developments in the understanding of neutropenia in several of the PIDDs make a review of the data timely.The ...
openaire   +2 more sources

Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Stage of Replication [PDF]

, 2010
Type I interferons (IFNα and β) are induced directly in response to viral infection, resulting in an antiviral state for the cell. In vitro studies have shown that IFNα is a potent inhibitor of viral replication; however, its role in HIV-1 infection is ...
McKnight, A, McKnight Áine, Cheney, KM, Kelly M Cheney, Áine McKnight, Cheney Kelly M.   +5 more
core   +2 more sources

The riddle of recurrent fever: a clinical approach to pediatric autoinflammatory diseases

Frontiers in Pediatrics
Autoinflammatory diseases (AIDs) are a group of immunodysregulatory disorders resulting in the increased release or signaling of pro-inflammatory cytokines.
B. Meertens, B. Meertens, L. Hoste, L. Hoste, S. J. Tavernier, S. J. Tavernier, S. J. Tavernier, S. J. Tavernier, F. Haerynck, F. Haerynck   +9 more
doaj   +1 more source

Ataxia Telangiectasia Diagnosed on Newborn Screening–Case Cohort of 5 Years' Experience

Frontiers in Immunology, 2019
Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase.
Amarilla B. Mandola, Amarilla B. Mandola, Brenda Reid, Brenda Reid, Raga Sirror, Rae Brager, Peter Dent, Pranesh Chakroborty, Dennis E. Bulman, Chaim M. Roifman, Chaim M. Roifman   +10 more
doaj   +1 more source

BCG: a vaccine with multiple faces

Human Vaccines & Immunotherapeutics, 2020
BCG has been recommended because of its efficacy against disseminated and meningeal tuberculosis. The BCG vaccine has other mechanisms of action besides tuberculosis protection, with immunomodulatory properties that are now being discovered. Reports have
Marco Antonio Yamazaki-Nakashimada, Alberto Unzueta, Luisa Berenise Gámez-González, Napoleón González-Saldaña, Ricardo U. Sorensen   +4 more
doaj   +1 more source

Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia’s experience over 26 years

Allergy, Asthma & Clinical Immunology, 2021
Background A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia. An analysis of the available database would establish clinical characteristics,
Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd. Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Iean Hamzah Sendut, Thiyagar Nadarajaw, Faizah Mohamed Jamil, David C. E. Ng, Mohd Azri Zainal Abidin   +22 more
doaj   +1 more source

Primary immunodeficiencies in adults [PDF]

Vnitřní lékařství, 2019
In contrast to general opinion, the issue of primary immunodeficiency is far from just a pediatric medicine; a large number of patients with primary immunodefciencies are not only treated, but also diagnosed in adulthood. The most important manifestation of these diseases are serious, unusual or ill-treatable infections.
openaire   +2 more sources

Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency

, 2007
Common Variable Immunodeficiency belongs to the group of rare diseases encompassing antibody deficiency syndromes of highly variable clinical presentation and outcome.
Claudio Pignata, Simona Donnanno, Franco Dammacco, A. M. Pesce, Network Within The Ipinet Italian Primary Immunodeficiency, Annarosa Soresina, QUINTI, Isabella, Carlo Agostini, Andrea Guerra, Silvana Martino, Alessandro Plebani, Roberto Rondelli, Giuseppe Spadaro, Federica Borghese   +13 more
core   +2 more sources

CRISPR-Cas9 gene editing approaches in colorectal cancer: Current progress and future prospects

Cancer Treatment and Research Communications
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, characterized by genetic heterogeneity and the accumulation of mutations in key oncogenes and tumor suppressor genes.
Mohadeseh Hassannia, Parisa Amirifar
doaj   +1 more source