Results 41 to 50 of about 4,951,275 (263)

Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets

Frontiers in Immunology
The Epstein–Barr virus (EBV) is usually acquired during infancy as an asymptomatic infection and persists throughout life in a latent state under the control of the host immune system.
Maria Giovanna Desimio, Daniela Angela Covino, Caterina Cancrini, Caterina Cancrini, Margherita Doria   +4 more
doaj   +1 more source

The riddle of recurrent fever: a clinical approach to pediatric autoinflammatory diseases

Frontiers in Pediatrics
Autoinflammatory diseases (AIDs) are a group of immunodysregulatory disorders resulting in the increased release or signaling of pro-inflammatory cytokines.
B. Meertens, B. Meertens, L. Hoste, L. Hoste, S. J. Tavernier, S. J. Tavernier, S. J. Tavernier, S. J. Tavernier, F. Haerynck, F. Haerynck   +9 more
doaj   +1 more source

Ataxia Telangiectasia Diagnosed on Newborn Screening–Case Cohort of 5 Years' Experience

Frontiers in Immunology, 2019
Ataxia telangiectasia (AT) is a genetic condition caused by mutations involving ATM (Ataxia Telangiectasia Mutated). This gene is responsible for the expression of a DNA double stranded break repair kinase, the ATM protein kinase.
Amarilla B. Mandola, Amarilla B. Mandola, Brenda Reid, Brenda Reid, Raga Sirror, Rae Brager, Peter Dent, Pranesh Chakroborty, Dennis E. Bulman, Chaim M. Roifman, Chaim M. Roifman   +10 more
doaj   +1 more source

BCG: a vaccine with multiple faces

Human Vaccines & Immunotherapeutics, 2020
BCG has been recommended because of its efficacy against disseminated and meningeal tuberculosis. The BCG vaccine has other mechanisms of action besides tuberculosis protection, with immunomodulatory properties that are now being discovered. Reports have
Marco Antonio Yamazaki-Nakashimada, Alberto Unzueta, Luisa Berenise Gámez-González, Napoleón González-Saldaña, Ricardo U. Sorensen   +4 more
doaj   +1 more source

Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia’s experience over 26 years

Allergy, Asthma & Clinical Immunology, 2021
Background A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia. An analysis of the available database would establish clinical characteristics,
Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd. Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Iean Hamzah Sendut, Thiyagar Nadarajaw, Faizah Mohamed Jamil, David C. E. Ng, Mohd Azri Zainal Abidin   +22 more
doaj   +1 more source

Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody [PDF]

, 2010
<b>BACKGROUND:</b> In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor.
Brian J Willett, Margaret J Hosie, Ayman Samman, McMonagle, Elizabeth L., Logan, Nicola, Nicola Logan, Hosie, Margaret J., Samman, Ayman, Willett, Brian J., Kraase, Martin, Martin Kraase, Elizabeth L McMonagle   +11 more
core   +1 more source

CRISPR-Cas9 gene editing approaches in colorectal cancer: Current progress and future prospects

Cancer Treatment and Research Communications
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, characterized by genetic heterogeneity and the accumulation of mutations in key oncogenes and tumor suppressor genes.
Mohadeseh Hassannia, Parisa Amirifar
doaj   +1 more source

A Nationwide Study of Severe and Protracted Diarrhoea in Patients with Primary Immunodeficiency Diseases

Scientific Reports, 2017
Diarrhoea lasting longer than 14 days and failing to respond to conventional management is defined as severe and protracted diarrhoea (SD). In this study, we investigated the prevalence, pathogens and prognosis of SD in primary immunodeficiency diseases (
Wen-I Lee, Chien-Chang Chen, Tang-Her Jaing, Liang-Shiou Ou, Chuen Hsueh, Jing-Long Huang   +5 more
doaj   +1 more source

Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point. [PDF]

, 2008
It is unknown whether patterns of human immunodeficiency virus (HIV)-specific T-cell responses during acute infection may influence the viral set point and the course of disease. We wished to establish whether the magnitude and breadth of HIV type 1 (HIV-
Gray, Clive M, van Loggerenberg, Francois, Mlotshwa, Mandla., Mathebula, Tiyani, Seoighe, Cathal., Morris, Lynn, Ngandu, Nobubelo K., Morris, Lynn., Mlisana, Koleka Patience., CAPRISA 002 Acute Infection Study Team, Gray, Clive M., Mlisana, Koleka, Riou, Catherine, Abdool Karim, Salim Safurdeen., Williamson, Carolyn., Mathebula, Tiyani., de Assis Rosa, Debra, Seoighe, Cathal, Mashishi, Tumelo., Mashishi, Tumelo, Williamson, Carolyn, Karim, Salim Abdool, de Assis Rosa, Debra., Ngandu, Nobubelo, Riou, Catherine., van Loggerenberg, Francois., Mlotshwa, Mandla   +26 more
core   +1 more source

Primary health care providers’ views on managing substance use among people living with HIV [PDF]

, 2023
The growing culture of substance use among people living with human immunodeficiency virus (PLWH) is a serious threat to the human immunodeficiency virus (HIV) pandemic. As the gatekeepers of comprehensive care, primary care providers are responsible for
Kaswa, Ramprakash, Marietjie de Villiers, De Villiers, Marietjie, Ramprakash Kaswa   +3 more
core   +1 more source