Results 11 to 20 of about 7,759 (229)
Inborn Errors of Immunity and Cancer [PDF]
Biology, 2021 Inborn Errors of Immunity (IEI) are a heterogeneous group of disorders characterized by a defect in the function of at least one, and often more, components of the immune system.
Alessandra Tiri +7 more
doaj +6 more sources
Endocrinopathies in Inborn Errors of Immunity [PDF]
Frontiers in Immunology, 2021 Inborn errors of immunity (IEI), caused by hereditary or genetic defects, are a group of more than 400 disorders, in which the immune system, including lymphocytes, neutrophils, macrophages, and complements, does not function properly.
Kei Takasawa +3 more
doaj +3 more sources
Inborn errors of immunity with eosinophilia
Allergology International, 2021 Monogenic diseases of the immune system, also known as inborn errors of immunity (IEIs), are caused by single-gene mutations and result in immune deficiency and dysregulation.
Keisuke Okamoto, Tomohiro Morio
doaj +3 more sources
Management change following NGS diagnosis of inborn errors of immunity: The Australasian experienceManagement change post NGS diagnosis of IEI in Australasia [PDF]
Journal of Human ImmunitySwamy et al. describe an Australian/New Zealand cohort where identification of monogenic inborn errors of immunity through next-generation sequencing resulted in management change in 84% of cases, including guiding hematopoietic stem cell transplants and
Shruti Swamy +36 more
doaj +2 more sources
Dendritic cells in inborn errors of immunity [PDF]
Frontiers in Immunology, 2023 Dendritic cells (DCs) are crucial cells for initiating and maintaining immune response. They play critical role in homeostasis, inflammation, and autoimmunity.
Sudhir Gupta, Anshu Agrawal
doaj +4 more sources
Inborn Errors of Immunity in Apoptosis
Frontiers in Bioscience-LandmarkInborn errors of immunity (IEIs) are a group of more than 485 disorders that impair immune development and function with variable reported incidence, severity, and clinical phenotypes.
Nadia Makkoukdji +6 more
doaj +3 more sources
IKZF-associated inborn errors of immunityIKZF-associated inborn errors of immunity [PDF]
Journal of Human ImmunityGermline variants in IKZF family proteins cause inborn errors of immunity characterized by variable degrees of immunodeficiency, immune dysregulation, and occasional malignancies.
Motoi Yamashita, Tomohiro Morio
doaj +4 more sources
Granulomatous inflammation in inborn errors of immunity
Frontiers in Pediatrics, 2023 Granulomas have been defined as inflammatory infiltrates formed by recruitment of macrophages and T cells. The three-dimensional spherical structure typically consists of a central core of tissue resident macrophages which may merge into multinucleated ...
Keith A. Sacco +3 more
doaj +3 more sources
Inborn errors of immunity in adulthood
Allergy, Asthma & Clinical ImmunologyInborn errors of immunity (IEIs) are a group of conditions whereby parts of the immune system are missing or dysfunctional. Once thought to primarily be a pediatric disorder, it is now estimated that more than 50% of worldwide incident IEI cases are ...
Joanne J. F. Wang +7 more
doaj +3 more sources
Inborn errors of immunity and related microbiome
Frontiers in Immunology, 2022 Inborn errors of immunity (IEI) are characterized by diverse clinical manifestations that are dominated by atypical, recurrent, chronic, or severe infectious or non-infectious features, including autoimmunity, lymphoproliferative disease, granulomas, and/
Raja Hazime +14 more
doaj +3 more sources