Results 111 to 120 of about 3,766,607 (390)

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox [PDF]

, 2020
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to ...
Almeida, Sérgio F. de, Huertas Sánchez, Pablo, Legube, Gaëlle, Vítor, Alexandra C.   +3 more
core   +3 more sources

Homologous recombination and the repair of DNA double-strand breaks

Journal of Biological Chemistry, 2018
Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix.
W. D. Wright, S. Shah, W. Heyer
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology
Targeted and immune therapies have improved patient outcomes in selected diseases. Still, resistance inevitably occurs, and a significant portion of the proteome remains undruggable due to target localisation, structural or functional constraints ...
Noé Herbel, Sophie Postel‐Vinay
doaj   +1 more source

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

npj Precision Oncology, 2022
Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the ...
Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues   +18 more
doaj   +1 more source

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

Nature Communications, 2018
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains poorly understood.
Wei-Ting Lu, Ben R. Hawley, George L. Skalka, R. Baldock, Ewan M Smith, Aldo S. Bader, M. Malewicz, F. Z. Watts, A. Wilczyńska, M. Bushell   +9 more
semanticscholar   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam

Cell Death and Disease
Mitochondrial dysfunction is a central aspect of Parkinson’s disease (PD) pathology, yet the underlying mechanisms are not fully understood. This study investigates the link between α-Synuclein (α-Syn) pathology and the loss of translocase of the outer ...
Velmarini Vasquez, Manohar Kodavati, Joy Mitra, Indira Vedula, Dale J. Hamilton, Ralph M. Garruto, K. S. Rao, Muralidhar L. Hegde   +7 more
doaj   +1 more source

The Role of NCOA4-Mediated Ferritinophagy in Health and Disease

Pharmaceuticals, 2018
Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy„), the cytosolic iron storage complex.
Naiara Santana-Codina, Joseph D. Mancias
doaj   +1 more source

Effect of DNA repair deficiencies on the cytotoxicity of resveratrol [PDF]

, 2015
Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial effects in a variety of disorders, including cancer, diabetes, Alzheimer, and cardiovascular diseases.
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, López Lázaro, Miguel, López Lázaro, Miguel (Coordinador), Mateos Cordero, Santiago, Orta Vázquez, Manuel Luis   +5 more
core