Results 151 to 160 of about 3,810,652 (392)
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance E-cigarette smoke (ECS) delivers nicotine through aerosols without burning tobacco. ECS is promoted as noncarcinogenic. We found that ECS induces DNA damage in mouse lung, bladder, and heart and reduces DNA-repair functions and proteins in ...
Hyun-wook Lee +8 more
semanticscholar +1 more source
The comings and goings of nucleotide excision repair factors on damaged DNA [PDF]
, 2003 Thilo Riedl +2 more
openalex +1 more source
Oncotarget, 2015 The retinoblastoma protein (RB1) has a welldocumented role as a key regulator of cell cycle progression by controlling the G1/S phase transition [1]. RB1 has also emerged as a multi-functional protein involved in a wide range of biological processes including transcriptional regulation by recruiting chromatin remodelling enzymes, DNA replication via ...
Paul H, Huang +2 more
openaire +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair
Frontiers in Aging Neuroscience, 2017 Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due ...
S. Zárate, T. Stevnsner, R. Gredilla
semanticscholar +1 more source
Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair [PDF]
, 2016 Corina Ohle +5 more
openalex +1 more source
BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling [PDF]
, 2022 Melissa Bradbury +8 more
openalex +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA [PDF]
, 2003 Pavel Vodic̆ka +16 more
openalex +1 more source