Results 151 to 160 of about 3,725,761 (393)
Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair
Frontiers in Aging Neuroscience, 2017 Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due ...
S. Zárate, T. Stevnsner, R. Gredilla
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
How cells ensure correct repair of DNA double-strand breaks
Journal of Biological Chemistry, 2018 DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause senescence or cell death. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are the two major DNA-repair pathways.
Joonyoung Her, S. Bunting
semanticscholar +1 more source
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
Nature Communications, 2017 APE1 plays an important role in the cellular response to oxidative stress, and mutations are linked to tumor progression and chemoresistance. Here, the authors characterize the interactions of APE1 with RNA and demonstrate a role in microRNA processing.
Giulia Antoniali +12 more
doaj +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Annual Review of Biochemistry, 1982 The invention relates to methods of selection of agents and compositions for the treatment of proliferative diseases such as cancer. More specifically, the present invention relates to the methods of selecting compounds which modulate the activity of DNA repair enzymes HAB1 and HAB2 and their uses in the treatment of disorders, which would benefit from
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Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Early intracellular events in the replication of T4 phage DNA, IV. Host-mediated single-stranded breaks and repair in ultraviolet-damaged T4 DNA. [PDF]
, 1967 Andrzej W. Kozinski, Z Lorkiewicz
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