Results 181 to 190 of about 528,873 (274)

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.)

Haematologica, 2019
Naiara Santana-Codina, Sebastian Gableske, Mark D. Fleming, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias   +5 more
doaj   +1 more source

Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair. [PDF]

Biomedicines
Khodyreva SN, Dyrkheeva NS, Lavrik OI.
europepmc   +1 more source

Establishment and biological characterization of radioresistant colorectal cancer cell lines

FEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu, Qing Dai, Jing Leng, Lin Fang, Jing‐Jing Ma, Rui Chen, Che Chen, Peng‐Fei Ran, Wen‐Wen Zhou, Chang Liu, Huang‐Fei Yu   +10 more
wiley   +1 more source

D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming. [PDF]

Nat Commun
Lang F, Kaur K, Fu H, Zaheer J, Ribeiro DL, Aladjem MI, Yang C.   +6 more
europepmc   +1 more source

Two Forms of Repair of DNA in Mammalian Cells following Irradiation

, 1970
M. M. Elkind, C. Kamper
openalex   +1 more source

An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)

FEBS Open Bio, EarlyView.
Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley   +1 more source

Corrigendum: Apigenin protects against ischemic stroke by increasing DNA repair. [PDF]

Front Pharmacol
Ping N, Zuo K, Cai J, Rong C, Yu Z, Zhang X, Wang G, Ma C, Yang H, Li J, Wang X, Zhao D.   +11 more
europepmc   +1 more source

Repair of Ultraviolet Light Damage to the DNA of Cultured Human Epidermal Keratinocytes and Fibroblasts

, 1979
Lorne B. Taichman, R. B. Setlow
openalex   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source