Results 181 to 190 of about 1,028,456 (338)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents [PDF]

, 2023
Alexandra L. Zakharenko, Nadezhda S. Dyrkheeva, Olga A. Luzina, Aleksandr S. Filimonov, Evgenii S. Mozhaitsev, Anastasia A. Malakhova, S. P. Medvedev, Suren M. Zakian, Нариман Ф. Салахутдинов, Olga I. Lavrik   +9 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors. [PDF]

NAR Cancer
Jeong S, Chung Y, Heo S, Myung K.
europepmc   +1 more source

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway [PDF]

Lin-Wen Yeh, J.C. Chen, Jia-Yun Yeh, Mei-Han Kao, Hsiao-Chin Hong, Sean M. Wu, Wai‐Mui Cheung, Ta-Yu Liu, Marvin Angelo Esteban Aberin, Ernesto Paas-Oliveros, Arian Escajeda, Edward S.C. Shih, Woan‐Yuh Tarn, Yao‐Ming Chang, Lan-Hsin Wang, Shu‐Ping Wang   +15 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The use of DNA repair inhibitors and the comet assay-an overview. [PDF]

Mutagenesis
Saenz-Martinez E, López de Cerain A, Azqueta A.   +2 more
europepmc   +1 more source

okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis [PDF]

, 1998
Amin S. Ghabrial, Robert P. Ray, Trudi Schüpbach   +2 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Gabija restricts phages that antagonize a conserved host DNA repair complex [PDF]

Alex Hong, M.-Y. Liu, Alexis Truta, Alexander Talaie, Gerald R. Smith, Joseph Bondy‐Denomy   +5 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source