Results 201 to 210 of about 1,028,456 (338)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Anwer D, Montaldo NP, Novoa-Del-Toro EM, Domanska D, Nilsen HL, Polster A.   +5 more
europepmc   +1 more source

Effects of DNA Adduct Structure and Sequence Context on Strand Opening of Repair Intermediates and Incision by UvrABC Nuclease

, 2003
Yue Zou, Steven M. Shell, Christopher D. Utzat, Charlie Luo, Zhengguan Yang, Nicholas E. Geacintov, Ashis K. Basu   +6 more
openalex   +1 more source

DNA Repeat Rearrangements Mediated by DnaK-Dependent Replication Fork Repair [PDF]

, 2006
Stephen J. Goldfless, Aviv Segal Morag, Kurt A. Belisle, Vincent A. Sutera, Susan T. Lovett   +4 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Impact of Germline DNA Repair Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Development. [PDF]

Curr Hematol Malig Rep
Fedorov K, Luo LY, Bick AG, Savona MR.
europepmc   +1 more source

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA [PDF]

, 2012
Atanu Maiti, Muhammad S. Noon, Alexander D. MacKerell, Edwin Pozharski, Alexander C. Drohat   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity. [PDF]

Nucleic Acids Res
Longmire P, Zeltzer S, Zarrella K, Daigle O, Svoboda M, Reitsma JM, Terhune SS, Bobak C, Bosco G, Goodrum F.   +9 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source