Results 271 to 280 of about 3,810,652 (392)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Repurposing clinically safe drugs for DNA repair pathway choice in CRISPR genome editing and synthetic lethality. [PDF]

Nat Commun
Macak D, Kanis P, Riesenberg S.
europepmc   +1 more source

Light‐driven DNA repair at atomic and picosecond resolution revealed via time‐resolved serial femtosecond crystallography [PDF]

Yuhei Hosokawa, Manuel Maestre‐Reyna
openalex   +1 more source

An oxidative DNA “damage” and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression [PDF]

, 2015
Viktor Pastukh, Justin T. Roberts, David W. Clark, Gina C. Bardwell, Mita Patel, Abu‐Bakr Al‐Mehdi, Glen M. Borchert, Mark N. Gillespie   +7 more
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1. [PDF]

J Clin Invest
Allam HS, Acklin-Wehnert S, Sadhukhan R, Patra M, Xia F.   +4 more
europepmc   +1 more source

Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells.

, 1990
Karsten Wassermann, Kurt W. Kohn, Vilhelm A. Bohr   +2 more
openalex   +1 more source

The rad18 Gene of Schizosaccharomyces pombe Defines a New Subgroup of the SMC Superfamily Involved in DNA Repair [PDF]

, 1995
Alan R. Lehmann, M. Walicka, Dominic J. F. Griffiths, Johanne M. Murray, Felicity Z. Watts, Shirley McCready, Antony M. Carr   +6 more
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Illuminating DNA repair in action: structural insights into a photocaged glycosylase complex. [PDF]

IUCrJ
Suga M.
europepmc   +1 more source