Results 361 to 370 of about 3,810,652 (392)
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Annual Review of Biochemistry, 1996
Eukaryotic cells have multiple mechanisms for repairing damaged DNA. 06-methylguanine-DNA methyltransferase directly reverses some simple alkylation adducts. However, most repair strategies excise lesions from DNA. Two major pathways are base excision repair (BER), which eliminates single damaged-base residues, and nucleotide excision repair (NER ...
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Eukaryotic cells have multiple mechanisms for repairing damaged DNA. 06-methylguanine-DNA methyltransferase directly reverses some simple alkylation adducts. However, most repair strategies excise lesions from DNA. Two major pathways are base excision repair (BER), which eliminates single damaged-base residues, and nucleotide excision repair (NER ...
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Current Protocols in Molecular Biology, 2008
AbstractIn vivo DNA damage impacts the genetic stability of an organism; therefore, multiple pathways utilizing a large number of enzymes have evolved to repair DNA damage. This unit focuses on enzymes involved in base excision repair (BER). The BER enzymes possessing N‐glycosylase activity can find and remove a wide variety of damaged bases in a sea ...
Thomas C, Evans, Nicole M, Nichols
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AbstractIn vivo DNA damage impacts the genetic stability of an organism; therefore, multiple pathways utilizing a large number of enzymes have evolved to repair DNA damage. This unit focuses on enzymes involved in base excision repair (BER). The BER enzymes possessing N‐glycosylase activity can find and remove a wide variety of damaged bases in a sea ...
Thomas C, Evans, Nicole M, Nichols
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Nature Cell Biology, 2015
A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
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A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
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DNA Glycosylases in DNA Repair
1986The excision of potentially mutagenic and lethal lesions from DNA proceeds by one of two different routes. DNA damage which results in a major distortion of the DNA double-helix is generally recognized by a high-molecular weight nuclease that cuts two phosphodiester bonds in the altered strand, one on each side of the lesion.
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Clinics in Haematology, 1980
A number of disparate clinical syndromes have been loosely grouped together under the leading of diseases of DNA repair. More logically they should perhaps be termed diseases of diminished capacity to cope with DNA damage, since in only three has defective DNA repair been established as a basis so far.
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A number of disparate clinical syndromes have been loosely grouped together under the leading of diseases of DNA repair. More logically they should perhaps be termed diseases of diminished capacity to cope with DNA damage, since in only three has defective DNA repair been established as a basis so far.
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Nature, 2005H. Farmer +13 more
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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.
Annual Review of Biochemistry, 2004A. Sancar +3 more
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