Results 71 to 80 of about 3,810,652 (392)

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

Haematologica, 2019
Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina, Sebastian Gableske, Maria Quiles del Rey, Beata Małachowska, Mark P. Jedrychowski, Douglas E. Biancur, Paul J. Schmidt, Mark D. Fleming, Wojciech Fendler, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias   +11 more
doaj   +1 more source

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage [PDF]

, 2003
The molecular role of poly (ADP-ribose) polymerase-1 in DNA repair is unclear. Here, we show that the single-strand break repair protein XRCC1 is rapidly assembled into discrete nuclear foci after oxidative DNA damage at sites of poly (ADP-ribose ...
Caldecott, Keith W., El-Khamisy, Sherif F., Masutani, Mitsuko, Suzuki, Hiroshi   +3 more
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Mfd Protects Against Oxidative Stress in Bacillus Subtilis Independently of its Canonical Function in DNA Repair [PDF]

, 2019
Background: Previous reports showed that mutagenesis in nutrient-limiting conditions is dependent on Mfd in Bacillus subtilis. Mfd initiates one type of transcription-coupled repair (TCR); this type of repair is known to target bulky lesions, like those ...
Contreras, Natalie, Ermi, Tatiana, Martin, Holly Anne, Pedraza-Reyes, Mario, Porter, Katelyne E., Robleto, Eduardo, Vallin, Carmen   +6 more
core   +5 more sources

DNA alteration and repair

Ecotoxicology and Environmental Safety, 1980
DNA alteration and repair is undoubtedly as essential stage in the mechanism of chemical carcinogenesis. Present knowledge has in fact shown, and in a rather convincing manner, that the majority of known chemical carcinogens, in addition to radiations and viruses, are also mutagens in the widest sense of the word and usually induce alteration of the ...
L, Santi, S, Parodi, M, Taningher, C F, Cesarone, C, Bolognesi   +4 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast

Nature Communications
SUMOylation, a conserved post-translational modification in eukaryotes, regulates protein function, localization, and stability. However, the role of SUMO chains in genome maintenance is still emerging.
Katarzyna Markowska, Ireneusz Litwin, Dorota Misiorna, Julia Kończak, Aleksandra Bogdańska, Paulina Tomaszewska, Michał Tracz, Mika Haenen, Karol Kramarz   +8 more
doaj   +1 more source

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays

STAR Protocols, 2021
Summary: Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow and supply blood cells. Efficient methods for isolation of HSPCs are required. Here, we present protocols for the isolation of human and murine HSPCs using manual and FACS-
Alfredo Rodríguez, Jessica Filiatrault, Patricia Flores-Guzmán, Héctor Mayani, Kalindi Parmar, Alan D. D’Andrea   +5 more
doaj   +1 more source

Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells [PDF]

, 2010
Copyright @ 2010 Gopalakrishnan et al; licensee BioMed Central Ltd.Background The Nucleotide Excision Repair (NER) pathway specialises in UV-induced DNA damage repair. Inherited defects in the NER can predispose individuals to Xeroderma Pigmentosum (XP).
Gopalakrishnan, K, Hande, P, Low, GKM, Slijepcevic, P, Srikanth, P, Ting, APL   +5 more
core   +2 more sources