Results 81 to 90 of about 3,810,652 (392)

DNA repair pathways and cisplatin resistance: an intimate relationship

Clinics, 2018
The main goal of chemotherapeutic drugs is to induce massive cell death in tumors. Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its remarkable efficiency, most tumors show intrinsic or acquired drug resistance. The
C. Rocha, Matheus Molina Silva, A. Quinet, J. Cabral-Neto, C. Menck   +4 more
semanticscholar   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

Molecular Brain
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in ALS includes increased genomic damage and impaired DNA repair capability. The TAR-DNA binding protein 43 (
Vincent E. Provasek, Manohar Kodavati, Brandon Kim, Joy Mitra, Muralidhar L. Hegde   +4 more
doaj   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Nature reviews. Molecular cell biology, 2017
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous
Howard H. Y. Chang, Nicholas R. Pannunzio, N. Adachi, M. Lieber   +3 more
semanticscholar   +1 more source

DNA repair on the brain [PDF]

Proceedings of the National Academy of Sciences, 2001
Xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) constitute a family of sun-sensitive human diseases (1). They are caused by mutations in the components of the nucleotide excision repair (NER) system and in the postreplication repair system involving the low-fidelity polymerase H (also known as XP variant or XPV).
R R, Laposa, J E, Cleaver
openaire   +2 more sources

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence

Acta Neuropathologica Communications
TDP-43 mislocalization and aggregation are key pathological features of amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD). However, existing transgenic hTDP-43 WT or ∆NLS-overexpression animal models primarily focus on late-stage TDP-
Joy Mitra, Manohar Kodavati, Prakash Dharmalingam, Erika N. Guerrero, K. S. Rao, Ralph M. Garruto, Muralidhar L. Hegde   +6 more
doaj   +1 more source

A Genome-Wide Analysis Reveals Significant Overlap of Transcription and DNA Repair in Stationary Phase Yeast [PDF]

, 2008
The association between transcription and DNA repair is acknowledged as a player in the generation of mutations in a non-random fashion in prokaryotes and eukaryotes.
Abraham Korol, Aviv de Morgan, Eviatar Nevo, Leonid Brodsky, Yechezkel Kashi, Yefim Ronin   +5 more
core   +1 more source

Genetic Requirements for Intra-Chromosomal Deletions [PDF]

, 2020
Chromosomal deletions are one of the most dangerous types of DNA damage and often arise as a result of inappropriately repaired DNA double strand breaks (DSB).
McPherson, Matthew
core