Results 141 to 150 of about 727,025 (334)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights

BioTech
DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders.
Jiawei Chen, Ravi Potlapalli, Heng Quan, Lingtao Chen, Ying Xie, Seyedamin Pouriyeh, Nazmus Sakib, Lichao Liu, Yixin Xie   +8 more
doaj   +1 more source

Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases. [PDF]

Basic Clin Pharmacol Toxicol, 2022
Karsten S.
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Apoptotic vesicles are required to repair DNA damage and suppress premature cellular senescence

Journal of Extracellular Vesicles
It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to DNA repair is largely unknown. In this study, we found that apoptosis‐deficient Fasmut and Bim−/− mice show significantly elevated DNA ...
Zhiqing Huang, Yuzhi Zhuang, Wenwen Li, Mingchen Ma, Fangcao Lei, Yan Qu, Jiaqi Li, Huigen Luo, Changzheng Li, Lu Lu, Lan Ma, Xiao Zhang, Xiaoxing Kou, Linjia Jiang, Xueli Mao, Songtao Shi   +15 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Escherichia coli induces DNA repair enzymes to protect itself from low-grade hydrogen peroxide stress. [PDF]

Mol Microbiol, 2022
Gupta A, Imlay JA.
europepmc   +1 more source

The Importance of DNA Repair in Tumor Suppression

, 2004
The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions.
B. Vogelstein, C. J. Sherr, C. Kamp, D. Voet, E. C. Friedberg, Eugene I. Shakhnovich, G. M. Cooper, K. H. Dragnev, Yisroel Brumer   +8 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Sequence Dependent Repair of 1,N⁶-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB. [PDF]

Molecules, 2021
Qi R, Bian K, Chen F, Tang Q, Zhou X, Li D.   +5 more
europepmc   +1 more source