Results 211 to 220 of about 219,333 (243)
Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities. [PDF]
Exp Hematol OncolWang YS, Qian LH, Liu CC, Yu KD.
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The role of NAD<sup>+</sup> metabolic reprogramming in colorectal cancer chemoresistance: mechanistic insights, clinical translation challenges and opportunities. [PDF]
Front OncolMa Z, Gong X, Liu F.
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RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment. [PDF]
MedComm (2020)Li Q, Sun Y, Lin S, Yuan Q.
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Annual Review of Biochemistry, 1988
DIRECT REPAIR: DNA PHOTOLYASES.. . . . ......... . ......... 31 Escherichia Coli Photolyase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 31 Saccharomyces Cerevisiae Photolyase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
A, Sancar, G B, Sancar
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DIRECT REPAIR: DNA PHOTOLYASES.. . . . ......... . ......... 31 Escherichia Coli Photolyase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 31 Saccharomyces Cerevisiae Photolyase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
A, Sancar, G B, Sancar
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Current Opinion in Structural Biology, 1997
Recent crystallographic studies of DNA-repair enzymes have provided the structural basis for the recognition of damaged DNA. The results imply that flipping out of the base is a common and crucial event in DNA repair. Two classes of repair enzymes that recognize distinct types of damage may exist.
D G, Vassylyev, K, Morikawa
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Recent crystallographic studies of DNA-repair enzymes have provided the structural basis for the recognition of damaged DNA. The results imply that flipping out of the base is a common and crucial event in DNA repair. Two classes of repair enzymes that recognize distinct types of damage may exist.
D G, Vassylyev, K, Morikawa
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"Active" photoprotection: sunscreens with DNA repair enzymes [PDF]
Italian Journal of Dermatology and Venereology, 2017 Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes.
Megna, Matteo +3 more
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Current Protocols in Molecular Biology, 2008
AbstractIn vivo DNA damage impacts the genetic stability of an organism; therefore, multiple pathways utilizing a large number of enzymes have evolved to repair DNA damage. This unit focuses on enzymes involved in base excision repair (BER). The BER enzymes possessing Nâglycosylase activity can find and remove a wide variety of damaged bases in a sea ...
Thomas C, Evans, Nicole M, Nichols
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AbstractIn vivo DNA damage impacts the genetic stability of an organism; therefore, multiple pathways utilizing a large number of enzymes have evolved to repair DNA damage. This unit focuses on enzymes involved in base excision repair (BER). The BER enzymes possessing Nâglycosylase activity can find and remove a wide variety of damaged bases in a sea ...
Thomas C, Evans, Nicole M, Nichols
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Tuberin regulates the DNA repair enzyme OGG1
American Journal of Physiology-Renal Physiology, 2008The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. The TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. We investigated a potential role for tuberin in regulating a key DNA repair pathway.
Samy L, Habib +5 more
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Aberrant activity of the DNA repair enzyme AlkB
Journal of Inorganic Biochemistry, 2004Escherichia coli AlkB is a DNA/RNA repair enzyme containing a mononuclear Fe(II) site that couples the oxidative decomposition of alpha-ketoglutarate (alphaKG) to the hydroxylation of 1-methyladenine or 3-methylcytosine lesions in DNA or RNA, resulting in release of formaldehyde and restoration of the normal bases.
Timothy F, Henshaw +2 more
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Enzymes involved in the repair of damaged DNA
Archives of Biochemistry and Biophysics, 1981The progress that has been made in our understanding of the enzymatic mechanisms by which modified nucleotides in DNA are recognized and repaired is due, in part, to the developments that have been made in photobiology and photochemistry. It was these areas of activity that led to the identification of the primary ultraviolet irradiation photoproducts ...
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