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Lymphocyte DNA adducts and polymorphism in the DNA repair enzyme XPD
Biomarkers, 2001The effect of genetic polymorphism of DNA repair enzyme on the DNA adduct levels was evaluated in this study. We explored the relationship between polymorphism in the nucleotide excision repair enzyme XPD and DNA adduct levels in lymphocytes. Lymphocyte DNA adducts were measured by a (32.)
M, Ichiba +7 more
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Detection of DNA point mutations with DNA mismatch repair enzymes
Carcinogenesis, 1994We have developed a simple and reliable procedure to screen gene mutations using DNA mismatch repair (MR) specific mut Y enzyme of Escherichia coli and thymidine DNA glycosylase from HeLa cells. The mut Y enzyme cleaves A of G/A mismatches in DNA duplex and thymidine glycosylase cleaves T at G/T mismatches.
I C, Hsu, Q, Yang, M W, Kahng, J F, Xu
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Death of an enzyme: suicide repair of DNA
Trends in Biochemical Sciences, 1983Abstract Alkylation of DNA forms lethal and mutagenic lesions, most of which are repaired by conventional enzymes. A unique activity has been discovered which corrects an important mutagenic adduct in one step, by a self-destructive mechanism.
Bruce Demple, Peter Karran
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Enzymes Involved in the Repair of DNA
1974Publisher Summary This chapter describes enzymes that have the potential to act upon irradiated DNA during different phases of an excision repair cycle. The duplex structure of DNA is maintained by relatively weak hydrogen bonds, which can be broken reversibly by either temperature or extremes in pH.
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DNA Repair Enzymes in Hyperthermophilic Archaea
1998The presence of hyperthermophilic microorganisms in hydrothermal environments at temperatures above 90°C is now well established (Stetter, 1990). In fact, isolates from deep sea marine hydrothermal vents can grow optimally under pressure at temperatures up to 113°C (Blochl et al., 1997).
Jocelyne Diruggiero, Frank T. Robb
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DNA Repair Enzymes in Mammalian Cells
1977In the past two decades, considerable strides have been made in understanding the phenomenon of DNA damage and its repair at all levels of biological organization. Studies on living cells using prokaryote models have been extensively reviewed by a number of authors (Town et al., 1973; Setlow and Setlow, 1972; Smith, 1971; Witkin, 1969; Hanawalt, 1968 ...
Errol C. Friedberg +3 more
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Liposome-Encapsulated Enzymes for DNA Repair
1992Skin cancer is the most common cancer in the Western world, and strong epidemiological evidence links solar UV exposure to the vast majority of these cancers [11]. Our current understanding of the multi-step neoplastic process has focused on DNA damage as an initiating event.
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DNA Repair: Enzymes for Survival and Development
2022Ingemar Ernberg +4 more
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