Results 281 to 290 of about 3,738,521 (387)

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune their activity in DNA replication. [PDF]

Nucleic Acids Res
O'Neal LG, Drucker MN, Lai NK, Clemente AF, Campbell AP, Way LE, Hong S, Holmes EE, Rancic SJ, Sawyer N, Wang X, Thrall ES.   +11 more
europepmc   +1 more source

Evidence for a DNA Replicative Genome for RNA-Containing Tumor Viruses [PDF]

, 1970
John P. Bader, Artrice V. Bader
openalex   +1 more source

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Science, 2014
Marija Maric, T. Maculins, Giacomo De Piccoli, K. Labib   +3 more
semanticscholar   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells. [PDF]

Leukemia
Mieland AO, Petrosino G, Dejung M, Chen JX, Fulzele A, Mahmoudi F, Tu JW, Mustafa AM, Zeyn Y, Hieber C, Bros M, Schnöder TM, Heidel FH, Najafi S, Oehme I, Hofmann I, Schutkowski M, Hilscher S, Kosan C, Butter F, Bhatia S, Sippl W, Krämer OH.   +22 more
europepmc   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling. [PDF]

Nat Commun
Chiou LF, Droby GN, Jayaprakash D, Anand JR, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Xie J, Wu D, Herring LE, Tomida J, Bowser JL, Vaziri C.   +14 more
europepmc   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Author Correction: Structures of the human leading strand Polε–PCNA holoenzyme

Nature Communications
Qing He, Feng Wang, Nina Y. Yao, Michael E. O’Donnell, Huilin Li   +4 more
doaj   +1 more source