Results 21 to 30 of about 1,048,189 (263)

Drf1-dependent Kinase Interacts with Claspin through a Conserved Protein Motif [PDF]

, 2010
The Dbf4/Drf1-dependent kinase (DDK) is required for the initiation of DNA replication in eukaryotes. Another protein, Claspin, mediates the activation of a cellular checkpoint response to stalled replication forks and is also a regulator of replication.
Aparicio, Arias, Chini, Chini, Clarke, Daniel A. Gold, Gambus, Hodgson, Jeong, Jiang, Kastan, Katou, Kim, Kumagai, Kumagai, Kumagai, Kumagai, Kumagai, Kumagai, Lee, Lee, Lin, Lou, Masai, Masai, Melo, Montagnoli, Moyer, Osborn, Pacek, Petermann, Roberts, Sar, Sheu, Silva, Ström, Szyjka, Takahashi, Takahashi, Takeda, Tenca, Tourrière, Tsuji, Tsuji, Walter, William G. Dunphy, Yanow, Yoo, Zou   +48 more
core   +3 more sources

Proteomic data on the nuclear interactome of human MCM9

Data in Brief, 2016
We present data relating to the interactome of MCM9 from the nuclei of human cells. MCM9 belongs to the AAA+ superfamily, and contains an MCM domain and motifs that may confer DNA helicase activity.
James R.A. Hutchins, Sabine Traver, Philippe Coulombe, Isabelle Peiffer, Magali Kitzmann, Daniel Latreille, Marcel Méchali   +6 more
doaj   +1 more source

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough, Berezney, Brown, Cardoso, Chevalier, Cook, Coverley, Coverley, den Hollander, Dijkwel, Djeliova, Fujita, Furstenthal, Geng, Geng, Harper, Hozak, Krude, Lowe, Mailand, Mitsui, Moore, Parisi, Radichev, Sherr, Stoeber, Su, Takeda, Tatsumi, Wilmes, Wohlschlegel   +30 more
core   +3 more sources

Getting ready for DNA duplication

eLife, 2019
The discovery of a biomolecular condensate involved in DNA replication has wide-ranging implications.
Nina Y Yao, Michael E O'Donnell
doaj   +1 more source

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

Nature Communications, 2022
Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, Shixin Liu   +5 more
doaj   +1 more source

Dicer prevents genome instability in response to replication stress [PDF]

, 2019
Dicer, an endoribonuclease best-known for its role in microRNA biogenesis and RNA interference pathway, has been shown to play a role in the DNA damage response and repair of double-stranded DNA breaks (DSBs) in mammalian cells.
Barra, Viviana, Bordignon, Benoit, Coquelle, Arnaud, Egger, Tom, Fragkos, Michalis, Lemacon, Delphine, Naim, Valeria   +6 more
core   +2 more sources

Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]

, 2010
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G, Jonsson, Zophonias O, Lopez-Mosqueda, Jaime, Maas, Nancy L, Toczyski, David P, Wohlschlegel, James   +5 more
core   +2 more sources

Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

Nature Communications, 2019
DNA damage triggers checkpoint signalling mechanisms. Here the authors reveal differential phosphorylation of targets of the Mec1-Ddc2 checkpoint kinase by analyzing the effect of quantitatively different ssDNA signals.
Susanne C. S. Bantele, Michael Lisby, Boris Pfander   +2 more
doaj   +1 more source

Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection

eLife, 2017
DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct ligation-based mechanisms. Pathway choice is made at the level of DNA end resection, a nucleolytic processing step, which primes DSBs for repair by recombination ...
Susanne CS Bantele, Pedro Ferreira, Dalia Gritenaite, Dominik Boos, Boris Pfander   +4 more
doaj   +1 more source

Tomato protoplast DNA transformation: physical linkage and recombination of exogenous DNA sequences [PDF]

, 1987
Tomato protoplasts have been transformed with plasmid DNA's, containing a chimeric kanamycin resistance gene and putative tomato origins of replication.
A Crossway, A Deshayes, B Reiss, BR Thomas, C-L Hsiao, CP Meredith, DT Stinchcomb, EA Shahin, FA Krens, G Scangos, HC Birnboim, HE Ruley, I Potrykus, J Messing, J Paszkowski, Jacques Hille, JD Rochaix, K Struhl, K Wernars, KC Reed, KR Folger, M Koornneef, M Perucho, Maarten Jongsma, Maarten Koornneef, MG Murray, MW Bevan, O Smithies, P Zabel, Pim Zabel, PW Rigby, R Hain, R Peerbolte, RA Anderson, RD Shillito, S Kato, SN Cohen, T Maniatis, TL Adams   +38 more
core   +4 more sources