Results 1 to 10 of about 31,191 (185)

Chromatin licensing and DNA replication factor 1 as a potential prognostic and diagnostic biomarker for gastric cancer [PDF]

Scientific Reports
Accurate and timely genetic material replication is essential for preserving genomic integrity. The replication process begins with chromatin licensing and DNA replication factor 1 (CDT1). It has been demonstrated that dysregulated CDT1 expression causes
Sijia Wang, Min Cui, Na Zhou, Meichen Tong, Shuhua Wu, Hong Li, Zhang Cao   +6 more
doaj   +3 more sources

SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication. [PDF]

J Biol Chem, 2014
Johansson P, Jeffery J, Al-Ejeh F, Schulz RB, Callen DF, Kumar R, Khanna KK.   +6 more
europepmc   +4 more sources

Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways [PDF]

Cell Division, 2007
In eukaryotes, DNA replication is strictly regulated so that it occurs only once per cell cycle. The mechanisms that prevent excessive DNA replication are focused on preventing replication origins from being reused within the same cell cycle.
Kim Youngjo, Kipreos Edward T
doaj   +6 more sources

Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1. [PDF]

Proc Natl Acad Sci U S A, 2012
Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW, You H.   +6 more
europepmc   +4 more sources

Chromatin Licensing and DNA Replication Factor 1 (CDT1) Is a Potential Prognostic Biomarker Involved in the Malignant Biological Behavior of Glioma. [PDF]

ACS Pharmacol Transl Sci
Glioma is the primary malignant tumor with the highest incidence rate in the adult central nervous system. The application of bioinformatics methods to analyze the RNA sequences of multiple gliomas revealed that the CDT1 gene has a significant impact on ...
Chen T, Meng J, Yu K, Huang T, Zhao J.
europepmc   +3 more sources

Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

Frontiers in Pharmacology, 2022
DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication ...
Nikolaos Karantzelis, Michalis Petropoulos, Valeria De Marco, David A. Egan, Alexander Fish, Evangelos Christodoulou, David W. Will, Joe D. Lewis, Anastassis Perrakis, Zoi Lygerou, Stavros Taraviras   +10 more
doaj   +2 more sources

Identification of CDT1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches [PDF]

PeerJ, 2023
Background Lung cancer has the highest cancer-related mortality worldwide. Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC).
Jing Jiang, Yu Zhang, Jun Wang, Xuefei Yang, Xingchang Ren, Hai Huang, Jue Wang, Jinhua Lu, Yazhen Zhong, Zechen Lin, Xianlei Lin, Yewei Jia, Shengyou Lin   +12 more
doaj   +3 more sources

A novel homozygous intronic variant in CDT1 that alters splicing causes Meier–Gorlin syndrome, and a review of published mutations and growth hormone treatments [PDF]

Orphanet Journal of Rare Diseases
Background Meier–Gorlin syndrome (MGORS) is a rare autosomal inherited form of primordial dwarfism. Pathogenic variants in 13 genes involved in DNA replication initiation have been identified in this disease, but homozygous intronic variants have never ...
Qing Li, Yichi Wu, Fucheng Meng, Zhuxi Li, Di Zhan, Xiaoping Luo   +5 more
doaj   +2 more sources

The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]

Scientific Reports, 2017
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Ravikiran Mahadevappa, Shun Ming Yuen, Qing Wen   +2 more
exaly   +5 more sources

CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma

Frontiers in Oncology, 2021
ObjectiveHepatocellular carcinoma (HCC) is one of the most common malignant tumors endangering human health and life in the 21st century. Chromatin licensing and DNA replication factor 1 (CDT1) is an important regulator of DNA replication licensing ...
Chenhui Cai, Ying Zhang, Xu Hu, Wenhui Hu, Sizhen Yang, Hao Qiu, Tongwei Chu   +6 more
doaj   +1 more source