Results 11 to 20 of about 31,191 (185)

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

eLife, 2021
Liquid–liquid phase separation (LLPS) of intrinsically disordered regions (IDRs) in proteins can drive the formation of membraneless compartments in cells. Phase-separated structures enrich for specific partner proteins and exclude others. Previously, we
Matthew W Parker, Jonchee A Kao, Alvin Huang, James M Berger, Michael R Botchan   +4 more
doaj   +2 more sources

Depletion of NK6 Homeobox 3 (NKX6.3) causes gastric carcinogenesis through copy number alterations by inducing impairment of DNA replication and repair regulation

Oncogenesis, 2021
Genomic stability maintenance requires correct DNA replication, chromosome segregation, and DNA repair, while defects of these processes result in tumor development or cell death.
Jung Hwan Yoon, Jung Woo Eun, Hassan Ashktorab, Duane T. Smoot, Jeong kyu Kim, Suk Woo Nam, Won Sang Park   +6 more
doaj   +2 more sources

Stress-Stimulated Mitogen-Activated Protein Kinases Control the Stability and Activity of the Cdt1 DNA Replication Licensing Factor [PDF]

Molecular and Cellular Biology, 2011
Srikripa Chandrasekaran, Ting Xu Tan, Jonathan R. Hall, Jeanette Gowen Cook   +3 more
semanticscholar   +3 more sources

Acetylation/Deacetylation Modulates the Stability of DNA Replication Licensing Factor Cdt1 [PDF]

Journal of Biological Chemistry, 2009
Proper expression of the replication licensing factor Cdt1 is primarily regulated post-translationally by ubiquitylation and proteasome degradation. In a screen to identify novel non-histone targets of histone deacetylases (HDACs), we found Cdt1 as a ...
Michele A. Glozak, Edward Seto
openalex   +2 more sources

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. [PDF]

EMBO Journal, 1994
J.F. Hofmann, David Beach
openalex   +2 more sources

Proteolysis of DNA Replication Licensing Factor Cdt1 in S-phase Is Performed Independently of Geminin through Its N-terminal Region

Journal of Biological Chemistry, 2004
Licensing of replication origins is carefully regulated in a cell cycle to maintain genome integrity. Using an in vivo ubiquitination assay and temperature-sensitive cell lines we demonstrate that Cdt1 in mammalian cells is degraded through ubiquitin ...
Hideo Nishitani, Zoi Lygerou, Takeharu Nishimoto   +2 more
openalex   +2 more sources

CDT1 (chromatin licensing and DNA replication factor 1)

, 2011
Ranjan Deka, Ranjan Tamuli
openalex   +3 more sources

Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing. [PDF]

Bioessays
Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Speck C, Reuter LM.
europepmc   +2 more sources

The Human Licensing Factor for DNA Replication Cdt1 Accumulates in G1 and Is Destabilized after Initiation of S-phase

Journal of Biological Chemistry, 2001
Hideo Nishitani, Stavros Taraviras, Zoi Lygerou, Takeharu Nishimoto   +3 more
openalex   +2 more sources

Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase. [PDF]

FEBS J
This study reveals the interaction between minichromosome maintenance protein 6 (MCM6) and Bloom syndrome helicase (BLM), which is essential for DNA replication and cancer progression. Using fluorescence polarization anisotropy and NMR, we show the MCM6 winged‐helix domain (WHD) binds to the MCM6 binding domain D (MBD‐D) of BLM. MCM6 and BLM expression
Yang MJ, Lee H, Kang D, Park CJ.
europepmc   +2 more sources