BHLHE22, targeted by deubiquitinating enzyme OTUD3, exerts an antitumor role in triple-negative breast cancer progression via transcriptionally inhibiting CDT1 [PDF]
Breast Cancer ResearchBackground Basic helix-loop-helix family, member e22 (BHLHE22), a basic helix loop helix transcription factor family member, functions vary in different types of cancer. Currently, its function in triple-negative breast cancer (TNBC) is unclear.
Lei Jiang +5 more
doaj +2 more sources
Chromatin licensing and DNA replication factor 1 as a potential prognostic and diagnostic biomarker for gastric cancer [PDF]
Scientific ReportsAccurate and timely genetic material replication is essential for preserving genomic integrity. The replication process begins with chromatin licensing and DNA replication factor 1 (CDT1). It has been demonstrated that dysregulated CDT1 expression causes
Sijia Wang +6 more
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Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways [PDF]
Cell Division, 2007 In eukaryotes, DNA replication is strictly regulated so that it occurs only once per cell cycle. The mechanisms that prevent excessive DNA replication are focused on preventing replication origins from being reused within the same cell cycle.
Kim Youngjo, Kipreos Edward T
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The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]
Scientific Reports, 2017 DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Ravikiran Mahadevappa +2 more
exaly +5 more sources
A novel homozygous intronic variant in CDT1 that alters splicing causes Meier–Gorlin syndrome, and a review of published mutations and growth hormone treatments [PDF]
Orphanet Journal of Rare DiseasesBackground Meier–Gorlin syndrome (MGORS) is a rare autosomal inherited form of primordial dwarfism. Pathogenic variants in 13 genes involved in DNA replication initiation have been identified in this disease, but homozygous intronic variants have never ...
Qing Li +5 more
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License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication. [PDF]
BioessaysOrigin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Frisbie V, Bleichert F.
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Identification of CDT1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches [PDF]
PeerJ, 2023 Background Lung cancer has the highest cancer-related mortality worldwide. Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC).
Jing Jiang +12 more
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Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing. [PDF]
BioessaysOrigin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Speck C, Reuter LM.
europepmc +2 more sources
Frontiers in Pharmacology, 2022 DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication ...
Nikolaos Karantzelis +10 more
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