Bioengineered, 2022 PCGEM1 facilitates prostate cancer (PCa) progression. This study aimed to elucidate the mechanism of action of PCGEM1 in PCa. The expression of PCGEM1, microRNA miR-129-5p, chromatin licensing, and DNA replication factor 1 (CDT1) was detected by ...
Q. Fu +8 more
semanticscholar +1 more source
Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation. [PDF]
PLoS ONE, 2012 The DNA replication-licensing factor Cdt1 is present during the G1 phase of the cell cycle. When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation.
Hiroki Sakaguchi +7 more
doaj +1 more source
Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. [PDF]
PLoS ONE, 2010 Oncogenes induce cell proliferation leading to replicative stress, DNA damage and genomic instability. A wide variety of cellular stresses activate c-Jun N-terminal kinase (JNK) proteins, but few studies have directly addressed the roles of JNK isoforms ...
Peila Chen +8 more
doaj +1 more source
The Impact of Deleting Stem-Loop 1 of Epstein–Barr Virus-Encoded RNA 1 on Cell Proliferation
Viruses, 2022 Epstein–Barr virus-encoded RNAs (EBERs) are two small, noncoding, structurally conserved transcripts, constitutively expressed at >106 copies per EBV-infected cell. They have been shown to drive cell growth.
Zubaida Hassan +2 more
doaj +1 more source
Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition. [PDF]
PLoS ONE, 2012 In many organisms early development is under control of the maternal genome and zygotic gene expression is delayed until the mid-blastula transition (MBT).
Sarah L Kerns +4 more
doaj +1 more source
Scientific Reports, 2022 Recently, we reported that extent of proliferation of atypical hepatocytes (atypical hepatocytes) was most important histological risk factor for development of hepatocellular carcinoma (HCC) from chronic hepatitis C or liver cirrhosis. Here, we aimed to
Mitsuhiko Moriyama +16 more
doaj +1 more source
Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture [PDF]
, 2012 DNA Replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Barry, J.D. +7 more
core +10 more sources
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage
Journal of Pathology, 2022 Chromatin licensing and DNA replication factor 1 (CDT1), a protein of the pre‐replicative complex, is essential for loading the minichromosome maintenance complex (MCM) helicases onto the origins of DNA replication.
Michalis Petropoulos +18 more
semanticscholar +1 more source
Evidence for a role of Arabidopsis CDT1 proteins in gametophyte development and maintenance of genome integrity [PDF]
, 2012 Meristems retain the ability to divide throughout the life cycle of plants, which can last for over 1000 years in some species. Furthermore, the germline is not laid down early during embryogenesis but originates from the meristematic cells relatively ...
Benhamed, Moussa +8 more
core +3 more sources
The Licensing Factor Cdt1 Links Cell Cycle Progression to the DNA Damage Response
Anticancer Research, 2020 The maintenance of genome integrity is essential for cellular survival and propagation. It relies upon the accurate and timely replication of the genetic material, as well as the rapid sensing and repairing of damage to DNA.
Alexandra Kanellou +4 more
semanticscholar +1 more source