CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma
Frontiers in Oncology, 2021 ObjectiveHepatocellular carcinoma (HCC) is one of the most common malignant tumors endangering human health and life in the 21st century. Chromatin licensing and DNA replication factor 1 (CDT1) is an important regulator of DNA replication licensing ...
Chenhui Cai +6 more
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Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation. [PDF]
PLoS ONE, 2012 The DNA replication-licensing factor Cdt1 is present during the G1 phase of the cell cycle. When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation.
Hiroki Sakaguchi +7 more
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Molecular determinants of phase separation for Drosophila DNA replication licensing factors
eLife, 2021 Liquid–liquid phase separation (LLPS) of intrinsically disordered regions (IDRs) in proteins can drive the formation of membraneless compartments in cells. Phase-separated structures enrich for specific partner proteins and exclude others. Previously, we
Matthew W Parker +4 more
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Oncogenesis, 2021 Genomic stability maintenance requires correct DNA replication, chromosome segregation, and DNA repair, while defects of these processes result in tumor development or cell death.
Jung Hwan Yoon +6 more
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Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. [PDF]
PLoS ONE, 2010 Oncogenes induce cell proliferation leading to replicative stress, DNA damage and genomic instability. A wide variety of cellular stresses activate c-Jun N-terminal kinase (JNK) proteins, but few studies have directly addressed the roles of JNK isoforms ...
Peila Chen +8 more
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Geminin is required for zygotic gene expression at the Xenopus mid-blastula transition. [PDF]
PLoS ONE, 2012 In many organisms early development is under control of the maternal genome and zygotic gene expression is delayed until the mid-blastula transition (MBT).
Sarah L Kerns +4 more
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The Impact of Deleting Stem-Loop 1 of Epstein–Barr Virus-Encoded RNA 1 on Cell Proliferation
Viruses, 2022 Epstein–Barr virus-encoded RNAs (EBERs) are two small, noncoding, structurally conserved transcripts, constitutively expressed at >106 copies per EBV-infected cell. They have been shown to drive cell growth.
Zubaida Hassan +2 more
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Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture [PDF]
, 2012 DNA Replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Barry, J.D. +7 more
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Scientific Reports, 2022 Recently, we reported that extent of proliferation of atypical hepatocytes (atypical hepatocytes) was most important histological risk factor for development of hepatocellular carcinoma (HCC) from chronic hepatitis C or liver cirrhosis. Here, we aimed to
Mitsuhiko Moriyama +16 more
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Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase. [PDF]
FEBS JThis study reveals the interaction between minichromosome maintenance protein 6 (MCM6) and Bloom syndrome helicase (BLM), which is essential for DNA replication and cancer progression. Using fluorescence polarization anisotropy and NMR, we show the MCM6 winged‐helix domain (WHD) binds to the MCM6 binding domain D (MBD‐D) of BLM. MCM6 and BLM expression
Yang MJ, Lee H, Kang D, Park CJ.
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