Results 31 to 40 of about 31,191 (185)

KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death. [PDF]

Cancer Sci
Bioinformatic analysis of 42 KLHL family genes identified KLHL5 as a potential prognostic biomarker for colorectal cancer (CRC), with higher expression in the common molecular subtype (CMS) 4 CRC, which is characterized by poorer overall and recurrence‐free survival rates compared to other CMS groups. KLHL5 immunohistochemical analysis was performed on
Habu K, Matsuoka Y, Hiyoshi H, Nakayama J, Watanabe K, Tate S, Sakaue T, Murai J, Uno K, Nishie H, Kubota E, Kataoka H, Joh T, Watanabe Y, Oshikiri T, Higashiyama S.   +15 more
europepmc   +2 more sources

A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]

, 2012
BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F, Duncker, Bernard P, Gidvani, Rohan D, Ingalls, Brian P, Li, Grace, McConkey, Brendan J, Sudmant, Peter   +6 more
core   +3 more sources

CDT1 drives replication overlicensing and enhances tumorigenesis in the gut†

Journal of Pathology, 2022
Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Recent decades have witnessed enormous progress in our understanding of the mechanisms that sustain CRC, even though the factors implicated in the initiation ...
G. Monteleone, C. Stolfi
semanticscholar   +1 more source

Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21

FEBS Open Bio, 2022
Cholangiocarcinoma (CC) has a poor prognosis and different driver genes depending on the site of onset. Intrahepatic CC is the second‐most common liver cancer after hepatocellular carcinoma, and novel therapeutic targets are urgently needed.
Etsushi Kawamura, Tsutomu Matsubara, Atsuko Daikoku, Sanae Deguchi, Masahiko Kinoshita, Hideto Yuasa, Hayato Urushima, Naoshi Odagiri, Hiroyuki Motoyama, Kohei Kotani, Ritsuzo Kozuka, Atsushi Hagihara, Hideki Fujii, Sawako Uchida‐Kobayashi, Shogo Tanaka, Shigekazu Takemura, Keiko Iwaisako, Masaru Enomoto, Y. H. Taguchi, Akihiro Tamori, Shoji Kubo, Kazuo Ikeda, Norifumi Kawada   +22 more
doaj   +1 more source

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa, A Fernández-Cid, Alberto Riera, Alejandra Fernández-Cid, AS Brewster, AY Lyubimov, B Stillman, BA Kelch, BI Khayrutdinov, Bruce Stillman, C Evrin, C Evrin, C Liu, C Santocanale, C Speck, C Speck, Cecile Evrin, Christian Speck, D Remus, D Remus, D Suck, E Arias-Palomo, EF Pettersen, EL Dueber, G Tang, GC Lander, GD Bowman, GD Pintilie, H Li, H Li, Hironori Kawakami, Huilin Li, I Ilves, IN Chesnokov, J Frigola, J Liu, J Sun, JC Randell, Jingchuan Sun, JL Bowers, L Zou, M Gaudier, M O'Donnell, MG Clarey, MG Clarey, ML Baker, ML Bochman, ML Bochman, ML Bochman, PW Lau, R Henderson, RC Heller, RD Klemm, RJ Fletcher, S Chen, S Donovan, S Onesti, S Waga, SE Moyer, SL Forsburg, SP Bell, SP Bell, Stefan A Samel, T Miyata, T Pape, Y Ishimi, Y Kawasaki, YH Kang, Z Chen   +68 more
core   +1 more source

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication [PDF]

, 2015
© 2015, Chang et al.To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
Speck, C
core   +1 more source

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma [PDF]

, 2020
We performed a small interfering RNA screen to identify targets for cutaneous squamous cell carcinoma (cSCC) therapy in the ubiquitin/ubiquitin-like system.
Boag, Garry, Chinner, Nerime, Fernandes, Kenneth, Garg, Amit K., Hepburn, Lydia A., Ibrahim, Adel F. M., Leigh, Irene M., McHugh, Angela, Proby, Charlotte M., Saville, Mark K.   +9 more
core   +4 more sources

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]

, 2019
Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan, Goode, Benjamin, Mondal, Gourish, Solomon, David A, Stevers, Meredith   +4 more
core   +2 more sources

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization [PDF]

, 2013
The origin recognition complex (ORC) of Saccharomyces cerevisiae binds origin DNA and cooperates with Cdc6 and Cdt1 to load the replicative helicase MCM2–7 onto DNA. Helicase loading involves two MCM2–7 hexamers that assemble into a double hexamer around
A. Fernandez-Cid, A. Riera, Bell, Bowers, Bray, C. Evrin, C. Speck, Casas-Terradellas, Chen, Cocker, Coleman, Costa, Donovan, Dueber, Gillespie, Herbig, Holm, J. Zech, Klemm, Krupinski, Laemmli, Liang, Liang, Liu, M. C. Herrera, Mizushima, Neuwald, P. Clarke, Perkins, R. Lurz, Randell, Remus, Remus, Roy, S. Brill, Schepers, Seki, Singleton, Steven, Stoeber, Takara, Tanaka, Watanabe, Weinreich, Wendler, Williams, Ying, Zhang   +47 more
core   +1 more source

Analysis of a temperature‐sensitive mutation in Uba1: Effects of the click reaction on subsequent immunolabeling of proteins involved in DNA replication

FEBS Open Bio, 2015
In our previous study, a Met‐to‐Ile substitution at amino acid 256 in the catalytic domain of Uba1 was determined in temperature‐sensitive CHO‐K1 mutant tsTM3 cells, which exhibited chromosomal instability and cell‐cycle arrest in the S to G2 phases with
Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue   +2 more
doaj   +1 more source