Results 41 to 50 of about 6,179 (159)

Helicase Loading at Chromosomal Origins of Replication [PDF]

, 2013
Loading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of replication, the loaded helicase is required for the ...
Bell, Stephen P., Kaguni, Jon M.
core   +1 more source

The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.

PLoS ONE, 2012
Like all DNA viruses, human cytomegalovirus (HCMV) infection is known to result in profound effects on host cell cycle. Infection of fibroblasts with HCMV is known to induce an advance in cell cycle through the G(0)-G(1) phase and then a subsequent ...
Emma Poole, Mark Bain, Linda Teague, Yoshinori Takei, Ron Laskey, John Sinclair   +5 more
doaj   +1 more source

A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division [PDF]

, 2019
The R2R3-MYB transcription factor FOUR LIPS (FLP) controls the stomatal terminal division through transcriptional repression of the cell cycle genes CYCLIN-DEPENDENT KINASE (CDK) B1s (CDKB1s), CDKA; 1, and CYCLIN A2s (CYCA2s).
Dong, Juan, Hu, Xiangyang, Jiang, Min, Le, Jie, Vanneste, Steffen, Wang, Hongzhe, Xiao, Chunwang, Yang, Kezhen, Zhu, Lingling   +8 more
core   +2 more sources

DNA replication determines timing of mitosis by restricting CDK1 and PLK1 activation [PDF]

, 2018
To maintain genome stability, cells need to replicate their DNA before dividing. The kinases CDK1 and PLK1 drive mitotic entry and become active when bulk DNA synthesis is completed at the S/G2 transition.
Akopyan, Karen, Bartek, Jiri, Hegarat, Nadia, Hochegger, Helfrid, Lemmens, Bennie, Lindqvist, Arne, Sala-Gaston, Joan   +6 more
core   +1 more source

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing [PDF]

, 2016
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure.
A Duursma, A Viale, AB Niculescu, AC Bester, AC Porter, AJ Holland, Akshay K. Ahuja, Alexander Polyzos, Ana Igea, Angel Nebreda, Antonis Kokkalis, Apolinar Maya-Mendoza, B Langmead, Begoña Canovas, C Delehouzé, C Vaziri, CG Havens, Claus Storgaard Sørensen, CM Beauséjour, CZ Zhang, D Ottaviani, David Walter, Dimitris Kletsas, Dimitris Thanos, E Gibbs, E Petermann, EA Georgakopoulou, EK Benson, EK Papachristou, Emanuel Kanavakis, Emma J. Haagensen, ES Venkatraman, Fani-Marlen Roumelioti, FB Couch, G Velimezi, H Beck, H Li, H Nishitani, HA Sikder, HH Cha, I Iraqui, I Murfuni, IB Roninson, Igor B. Roninson, IS Pateras, J Bartkova, J Essers, J Pines, J Yu, J. Julian Blow, JCF de Winter, JH Barlow, Jiri Bartek, JJ Blow, JJ Blow, JR Rosai, JW Shay, K Chen, K Evangelou, K Hanada, KJ Neelsen, KJ Neelsen, KJ Neelsen, KJ Neelsen, Konstantinos Vougas, M Liontos, M Liontos, M Sideridou, M Terradas, Maria Tzetis, Massimo Lopes, MJ Peart, ML Agarwal, N Rivlin, NA Warfel, ND Perkins, P Karakaidos, Panagiotis Galanos, Paul Townsend, PJ Hastings, PJ Stephens, R Zellweger, RA Burrell, RA Woo, Ralph Zellweger, RH Ramirez-Gonzalez, S Bates, S Gonzalez, S Jørgensen, S Negrini, Sarantis Gagos, Sofia Havaki, Spiros D. Garbis, T Abbas, T Abbas, T Cooks, TD Halazonetis, TG Petrakis, Vassilis G. Gorgoulis, VG Gorgoulis, VN Budhavarapu, Y Wu   +101 more
core   +3 more sources

Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome.

PLoS Genetics, 2013
Mutations in ORC1, ORC4, ORC6, CDT1, and CDC6, which encode proteins required for DNA replication origin licensing, cause Meier-Gorlin syndrome (MGS), a disorder conferring microcephaly, primordial dwarfism, underdeveloped ears, and skeletal ...
Tom Stiff, Meryem Alagoz, Diana Alcantara, Emily Outwin, Han G Brunner, Ernie M H F Bongers, Mark O'Driscoll, Penny A Jeggo   +7 more
doaj   +1 more source

Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation [PDF]

, 2016
Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Damasceno, Jeziel D., Lemgruber Soares, Leandro, Marcello, Lucio, Marques, Catarina A., McCulloch, Richard, Paape, Daniel, Scott, Alan, Tiengwe, Calvin   +7 more
core   +3 more sources

CRL4(CDT2) targets CHK1 for PCNA-independent destruction [PDF]

, 2013
CDT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4). CRL4(CDT2) recruits these substrates through interactions with chromatin-bound
Huh, Jiwon, Piwnica-Worms, Helen
core   +2 more sources

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing [PDF]

, 2017
The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear.
A Costa, A Fernández-Cid, A Schepers, AA Hoskins, AY Lyubimov, BA Kelch, BA Smith, C Evrin, D Remus, DJ Crawford, F Chang, G Coster, H Yardimci, I Chen, Ivan R Corrêa, J Frigola, J Sun, J Sun, JCW Randell, Jeff Gelles, JL Bowers, JTP Yeeles, Kanokwan Champasa, Larry J Friedman, LJ Friedman, LJ Friedman, LJ Friedman, M Kindermann, ML Bochman, N Li, OM Aparicio, RY Samson, S Donovan, S Kang, S Ticau, SA Samel, Simina Ticau, SP Bell, Stephen P Bell, TD Deegan   +39 more
core   +2 more sources

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source