Results 41 to 50 of about 31,191 (185)

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +4 more sources

A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division [PDF]

, 2019
The R2R3-MYB transcription factor FOUR LIPS (FLP) controls the stomatal terminal division through transcriptional repression of the cell cycle genes CYCLIN-DEPENDENT KINASE (CDK) B1s (CDKB1s), CDKA; 1, and CYCLIN A2s (CYCA2s).
Dong, Juan, Hu, Xiangyang, Jiang, Min, Le, Jie, Vanneste, Steffen, Wang, Hongzhe, Xiao, Chunwang, Yang, Kezhen, Zhu, Lingling   +8 more
core   +2 more sources

The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.

PLoS ONE, 2012
Like all DNA viruses, human cytomegalovirus (HCMV) infection is known to result in profound effects on host cell cycle. Infection of fibroblasts with HCMV is known to induce an advance in cell cycle through the G(0)-G(1) phase and then a subsequent ...
Emma Poole, Mark Bain, Linda Teague, Yoshinori Takei, Ron Laskey, John Sinclair   +5 more
doaj   +1 more source

Helicase Loading at Chromosomal Origins of Replication [PDF]

, 2013
Loading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of replication, the loaded helicase is required for the ...
Bell, Stephen P., Kaguni, Jon M.
core   +1 more source

The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma

Journal of clinical biochemistry and nutrition, 2023
We previously reported that chromatin licensing and DNA replication factor 1 (CDT1) expression was associated with the extent of proliferation of atypical hepatocytes and the time to postoperative recurrence in cases of hepatocellular carcinoma (HCC ...
M. Ogawa, M. Moriyama, Y. Midorikawa, H. Nakamura, Toshikatu Shibata, K. Kuroda, H. Nakayama, Kazunori Kanemaru, Toshio Miki, M. Sugitani, T. Takayama   +10 more
semanticscholar   +1 more source

Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome.

PLoS Genetics, 2013
Mutations in ORC1, ORC4, ORC6, CDT1, and CDC6, which encode proteins required for DNA replication origin licensing, cause Meier-Gorlin syndrome (MGS), a disorder conferring microcephaly, primordial dwarfism, underdeveloped ears, and skeletal ...
Tom Stiff, Meryem Alagoz, Diana Alcantara, Emily Outwin, Han G Brunner, Ernie M H F Bongers, Mark O'Driscoll, Penny A Jeggo   +7 more
doaj   +1 more source

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing [PDF]

, 2016
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure.
A Duursma, A Viale, AB Niculescu, AC Bester, AC Porter, AJ Holland, Akshay K. Ahuja, Alexander Polyzos, Ana Igea, Angel Nebreda, Antonis Kokkalis, Apolinar Maya-Mendoza, B Langmead, Begoña Canovas, C Delehouzé, C Vaziri, CG Havens, Claus Storgaard Sørensen, CM Beauséjour, CZ Zhang, D Ottaviani, David Walter, Dimitris Kletsas, Dimitris Thanos, E Gibbs, E Petermann, EA Georgakopoulou, EK Benson, EK Papachristou, Emanuel Kanavakis, Emma J. Haagensen, ES Venkatraman, Fani-Marlen Roumelioti, FB Couch, G Velimezi, H Beck, H Li, H Nishitani, HA Sikder, HH Cha, I Iraqui, I Murfuni, IB Roninson, Igor B. Roninson, IS Pateras, J Bartkova, J Essers, J Pines, J Yu, J. Julian Blow, JCF de Winter, JH Barlow, Jiri Bartek, JJ Blow, JJ Blow, JR Rosai, JW Shay, K Chen, K Evangelou, K Hanada, KJ Neelsen, KJ Neelsen, KJ Neelsen, KJ Neelsen, Konstantinos Vougas, M Liontos, M Liontos, M Sideridou, M Terradas, Maria Tzetis, Massimo Lopes, MJ Peart, ML Agarwal, N Rivlin, NA Warfel, ND Perkins, P Karakaidos, Panagiotis Galanos, Paul Townsend, PJ Hastings, PJ Stephens, R Zellweger, RA Burrell, RA Woo, Ralph Zellweger, RH Ramirez-Gonzalez, S Bates, S Gonzalez, S Jørgensen, S Negrini, Sarantis Gagos, Sofia Havaki, Spiros D. Garbis, T Abbas, T Abbas, T Cooks, TD Halazonetis, TG Petrakis, Vassilis G. Gorgoulis, VG Gorgoulis, VN Budhavarapu, Y Wu   +101 more
core   +3 more sources

HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.

Genes & Development, 2008
HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is ...
B. Miotto, K. Struhl
semanticscholar   +1 more source

CRL4(CDT2) targets CHK1 for PCNA-independent destruction [PDF]

, 2013
CDT2 targets proteins involved in replication licensing (CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4). CRL4(CDT2) recruits these substrates through interactions with chromatin-bound
Huh, Jiwon, Piwnica-Worms, Helen
core   +2 more sources

Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

OncoTarget, 2015
During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging cytometry as exemplified by laser scanning cytometry (LSC) has been used to assess changes in ...
Z. Darżynkiewicz, Hong Zhao, Sufang Zhang, Marietta Y. W. T. Lee, Ernest Y. C. Lee, Zhongtao Zhang   +5 more
semanticscholar   +1 more source