Results 51 to 60 of about 31,191 (185)

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines [PDF]

, 2017
In late mitosis and G1, origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2-7.
Blow, J. Julian, Carrington, Jamie T., Frearson, Julie A., Gardner, Nicola J., Gillespie, Peter J., Haagensen, Emma J., McElroy, Stuart P., Shanks, Emma J., Woodland, Andrew   +8 more
core   +2 more sources

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing [PDF]

, 2017
The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear.
A Costa, A Fernández-Cid, A Schepers, AA Hoskins, AY Lyubimov, BA Kelch, BA Smith, C Evrin, D Remus, DJ Crawford, F Chang, G Coster, H Yardimci, I Chen, Ivan R Corrêa, J Frigola, J Sun, J Sun, JCW Randell, Jeff Gelles, JL Bowers, JTP Yeeles, Kanokwan Champasa, Larry J Friedman, LJ Friedman, LJ Friedman, LJ Friedman, M Kindermann, ML Bochman, N Li, OM Aparicio, RY Samson, S Donovan, S Kang, S Ticau, SA Samel, Simina Ticau, SP Bell, Stephen P Bell, TD Deegan   +39 more
core   +2 more sources

DNA replication determines timing of mitosis by restricting CDK1 and PLK1 activation [PDF]

, 2018
To maintain genome stability, cells need to replicate their DNA before dividing. The kinases CDK1 and PLK1 drive mitotic entry and become active when bulk DNA synthesis is completed at the S/G2 transition.
Akopyan, Karen, Bartek, Jiri, Hegarat, Nadia, Hochegger, Helfrid, Lemmens, Bennie, Lindqvist, Arne, Sala-Gaston, Joan   +6 more
core   +1 more source

Clinical significance of CDT1 mRNA expression in chronic hepatitis C or liver cirrhosis

Journal of clinical biochemistry and nutrition, 2023
We have previously reported that chromatin licensing and DNA replication factor 1 (CDT1) is associated with the postoperative recurrence of hepatocellular carcinoma (HCC).
M. Ogawa, M. Moriyama, H. Nakamura, Toshikatu Shibata, K. Kuroda, M. Sugitani   +5 more
semanticscholar   +1 more source

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.

PLoS Biology, 2019
Circadian disruption has multiple pathological consequences, but the underlying mechanisms are largely unknown. To address such mechanisms, we subjected transformed cultured cells to chronic circadian desynchrony (CCD), mimicking a chronic jet-lag scheme,
Yool Lee, Nicholas F Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M Field, Amita Sehgal   +5 more
doaj   +1 more source

A conserved MCM single-stranded DNA binding element is essential for replication initiation [PDF]

, 2013
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA.
Abrahams, Afonine, Aparicio, Aravind, Atanassova, Bae, Barry, Barry, Bell, Bochman, Bochman, Brewster, Brunger, Brunger, Chan, Chong, Costa, Costa, Davey, Enemark, Enemark, Esnouf, Evrin, Fletcher, Fu, Gomez-Llorente, Heller, Ilves, Itsathitphaisarn, Kanemaki, Kaplan, Labib, Laskowski, Liu, Maiorano, McCoy, McGeoch, Merritt, Mossessova, Moyer, Neuwald, Otwinowski, Pape, Pucci, Pucci, Raghunathan, Randell, Remus, Remus, Sakakibara, Sanner, Schrodinger, Schwacha, Skordalakes, Takayama, Tanaka, Thomsen, Vagin, Vagin, Wei, Winn, Yardimci   +61 more
core   +2 more sources

Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome

Journal of Zhejiang University SCIENCE B, 2023
The cell cycle consists of four distinct phases: G0/G1, S (DNA synthesis), G2, and M (mitosis). The G1 to S transition is typified by an accumulation of 4',6-diamidino-2-phenylindole (DAPI) signal that indi‐ cates the rapid DNA synthesis initiated at ...
Yinan He, Yong Wang, Yanqing Zhu, L. Lo
semanticscholar   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Small Methods, EarlyView.
This study describes the development and applications of a transgenic lamin‐based senescence reporter platform based on changes in lamin‐B1‐ and lamin‐A intensities during senescence‐induction. The reporter platform is a versatile tool, allowing to screen for and sort senescent cancer cells, allowing marker integration (for example incorporating IL6 ...
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk, Thom Reuvers, Jose M. Heredia‐Genestar, Anja Raams, Tsung Wai Kan, Joris Pothof, Roland Kanaar, Maayke M.P. Kuijten   +10 more
wiley   +1 more source

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core