Results 51 to 60 of about 6,179 (159)

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines [PDF]

, 2017
In late mitosis and G1, origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2-7.
Blow, J. Julian, Carrington, Jamie T., Frearson, Julie A., Gardner, Nicola J., Gillespie, Peter J., Haagensen, Emma J., McElroy, Stuart P., Shanks, Emma J., Woodland, Andrew   +8 more
core   +2 more sources

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.

PLoS Biology, 2019
Circadian disruption has multiple pathological consequences, but the underlying mechanisms are largely unknown. To address such mechanisms, we subjected transformed cultured cells to chronic circadian desynchrony (CCD), mimicking a chronic jet-lag scheme,
Yool Lee, Nicholas F Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M Field, Amita Sehgal   +5 more
doaj   +1 more source

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, Volume 7, Issue 1, January 2026.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source

The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle [PDF]

, 2012
Recent genome-wide mapping of the mammalian replication origins has suggested the role of transcriptional regulatory elements in origin activation. However, the nature of chromatin modifications associated with such trans-factors or epigenetic marks ...
Kumar, V, Singh, AK, Swarnalatha, M
core   +1 more source

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Small Methods, Volume 9, Issue 12, December 1, 2025.
This study describes the development and applications of a transgenic lamin‐based senescence reporter platform based on changes in lamin‐B1‐ and lamin‐A intensities during senescence‐induction. The reporter platform is a versatile tool, allowing to screen for and sort senescent cancer cells, allowing marker integration (for example incorporating IL6 ...
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk, Thom Reuvers, Jose M. Heredia‐Genestar, Anja Raams, Tsung Wai Kan, Joris Pothof, Roland Kanaar, Maayke M.P. Kuijten   +10 more
wiley   +1 more source

A conserved MCM single-stranded DNA binding element is essential for replication initiation [PDF]

, 2013
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA.
Abrahams, Afonine, Aparicio, Aravind, Atanassova, Bae, Barry, Barry, Bell, Bochman, Bochman, Brewster, Brunger, Brunger, Chan, Chong, Costa, Costa, Davey, Enemark, Enemark, Esnouf, Evrin, Fletcher, Fu, Gomez-Llorente, Heller, Ilves, Itsathitphaisarn, Kanemaki, Kaplan, Labib, Laskowski, Liu, Maiorano, McCoy, McGeoch, Merritt, Mossessova, Moyer, Neuwald, Otwinowski, Pape, Pucci, Pucci, Raghunathan, Randell, Remus, Remus, Sakakibara, Sanner, Schrodinger, Schwacha, Skordalakes, Takayama, Tanaka, Thomsen, Vagin, Vagin, Wei, Winn, Yardimci   +61 more
core   +2 more sources

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional profiling of E7-expressing cells [PDF]

, 2016
The E7 oncoprotein of the high-risk human papillomavirus (HPV) plays a major role in HPV-induced carcinogenesis. E7 abrogates the G(1) cell cycle checkpoint and induces genomic instability, but the mechanism is not fully understood.
Chen, Jason J, Gao, Ge, Liu, Yafei, Wang, Xiaowei, Yuan, Shoudao, Zhang, Qishu, Zhang, Xiaoli, Zhou, Yunying   +7 more
core   +3 more sources