Results 61 to 70 of about 6,179 (159)

Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly

Cancer Science, Volume 116, Issue 10, Page 2763-2773, October 2025.
Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso, Hironori Inaba, Masato T. Kanemaki, Esteban C. Gabazza, Hidemi Toyoda, Masahiro Hirayama, Hidemasa Goto   +6 more
wiley   +1 more source

Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function [PDF]

, 2014
Eukaryotic cells license each DNA replication origin during G1 phase by assembling a prereplication complex that contains a Mcm2-7 (minichromosome maintenance proteins 2-7) double hexamer.
Fernandez-Cid, A., Li, H., Riera, A., Speck, C., Stillman, B., Sun, J., Tognetti, S., Yuan, Z.   +7 more
core   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, Volume 12, Issue 35, September 18, 2025.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death

Cancer Science, Volume 116, Issue 9, Page 2444-2456, September 2025.
Bioinformatic analysis of 42 KLHL family genes identified KLHL5 as a potential prognostic biomarker for colorectal cancer (CRC), with higher expression in the common molecular subtype (CMS) 4 CRC, which is characterized by poorer overall and recurrence‐free survival rates compared to other CMS groups. KLHL5 immunohistochemical analysis was performed on
Kyosuke Habu, Yosuke Matsuoka, Hiromi Hiyoshi, Jun Nakayama, Katsuya Watanabe, Sota Tate, Tomohisa Sakaue, Junko Murai, Konomu Uno, Hirotada Nishie, Eiji Kubota, Hiromi Kataoka, Takashi Joh, Yuji Watanabe, Taro Oshikiri, Shigeki Higashiyama   +15 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, Volume 19, Issue 8, Page 2174-2195, August 2025.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration [PDF]

, 2013
The Cul4-Cdt2 (CRL4(Cdt2)) E3 ubiquitin ligase is a master regulator of cell-cycle progression and genome stability. Despite its central role in the degradation of many cell-cycle regulators, e.g., Cdt1, p21, and Pr-Set7/Set8, little is known about the ...
Abbas, Tarek, Dutta, Anindya, Keaton, Mignon, Mueller, Adam C., Rossi, Mario, Shibata, Etsuko   +5 more
core   +1 more source

The ABAP1 interacting protein 10 (AIP10) exerts a dual role in the cell cycle and primary metabolism pathways in Arabidopsis thaliana

The Plant Journal, Volume 123, Issue 3, August 2025.
Significance Statement Plants regulate cell division to adapt growth to environmental changes. In Arabidopsis thaliana, AIP10 acts as a hub linking the cell cycle to primary metabolism. Its silencing increases cell division rates, enhances carbon fixation, and boosts metabolite accumulation, driving improved development and productivity. SUMMARY Plants
Patrícia Montessoro, Joaquin Felipe Roca Paixão, Carinne N. M. Costa, Laura Ducatti, Letícia Perdigão Grangeiro, Vivian Ruivo, Adriana Flores Fusaro, Helkin F. Ballesteros, Vanessa Iurif, Luiz Mors Cabral, Jelmir Craveiro de Andrade, Leticia Tessaro, Wallace de Paula Bernado, Fernanda Silva Coelho, Bruna Gino de Araújo‐Lopes, Janice de Almeida Engler, Jérémie Bazin, Eliemar Campostrini, Carlos Adam Conte‐Junior, Adriana Silva Hemerly   +19 more
wiley   +1 more source

Replication fork instability and the consequences of fork collisions from rereplication [PDF]

, 2016
Replication forks encounter obstacles that must be repaired or bypassed to complete chromosome duplication before cell division. Proteomic analysis of replication forks suggests that the checkpoint and repair machinery travels with unperturbed forks ...
Alexander, Jessica Lynne, Orr-Weaver, Terry   +1 more
core   +1 more source

Ubiquitylation, neddylation and the DNA damage response. [PDF]

, 2015
Failure of accurate DNA damage sensing and repair mechanisms manifests as a variety of human diseases, including neurodegenerative disorders, immunodeficiency, infertility and cancer.
Brown, Jessica S, Jackson, Stephen P
core   +2 more sources

Covalent Inhibition of the Peptidyl‐Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2‐OS Cells

PROTEOMICS, Volume 25, Issue 14, July 2025.
ABSTRACT Peptidyl‐prolyl isomerase, NIMA‐interacting protein 1‐(Pin1) catalyses the cis–trans interconversion of the inflexible bond between serine or threonine residues and proline at the +1 position (pSer/pThr‐Pro). Although initially discovered as an essential regulator of cell division, Pin1 has since been identified as a regulator of many ...
Scott E. Roffey, Owen Hovey, Kristina Jurcic, Kun Ping Lu, Xiao Zhen Zhou, David W. Litchfield   +5 more
wiley   +1 more source