Results 61 to 70 of about 31,191 (185)

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly

Cancer Science, Volume 116, Issue 10, Page 2763-2773, October 2025.
Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso, Hironori Inaba, Masato T. Kanemaki, Esteban C. Gabazza, Hidemi Toyoda, Masahiro Hirayama, Hidemasa Goto   +6 more
wiley   +1 more source

Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex [PDF]

, 2016
All organisms ensure once and only once replication during S phase through a process called replication licensing. Cdt1 is a key component and crucial loading factor of Mcm complex, which is a central component for the eukaryotic replicative helicase. In
Haruhiko Takisawa, Hisao Masai, Koji L. Ode, Mayumi Shindo, Zhiying You   +4 more
core   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, Volume 12, Issue 35, September 18, 2025.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, Volume 19, Issue 8, Page 2174-2195, August 2025.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation [PDF]

, 2016
Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Damasceno, Jeziel D., Lemgruber Soares, Leandro, Marcello, Lucio, Marques, Catarina A., McCulloch, Richard, Paape, Daniel, Scott, Alan, Tiengwe, Calvin   +7 more
core   +3 more sources

The ABAP1 interacting protein 10 (AIP10) exerts a dual role in the cell cycle and primary metabolism pathways in Arabidopsis thaliana

The Plant Journal, Volume 123, Issue 3, August 2025.
Significance Statement Plants regulate cell division to adapt growth to environmental changes. In Arabidopsis thaliana, AIP10 acts as a hub linking the cell cycle to primary metabolism. Its silencing increases cell division rates, enhances carbon fixation, and boosts metabolite accumulation, driving improved development and productivity. SUMMARY Plants
Patrícia Montessoro, Joaquin Felipe Roca Paixão, Carinne N. M. Costa, Laura Ducatti, Letícia Perdigão Grangeiro, Vivian Ruivo, Adriana Flores Fusaro, Helkin F. Ballesteros, Vanessa Iurif, Luiz Mors Cabral, Jelmir Craveiro de Andrade, Leticia Tessaro, Wallace de Paula Bernado, Fernanda Silva Coelho, Bruna Gino de Araújo‐Lopes, Janice de Almeida Engler, Jérémie Bazin, Eliemar Campostrini, Carlos Adam Conte‐Junior, Adriana Silva Hemerly   +19 more
wiley   +1 more source

Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

Journal of Biological Chemistry, 2010
In eukaryotes, DNA replication is fired once in a single cell cycle before cell division starts to maintain stability of the genome. This event is tightly controlled by a series of proteins.
J. Jee, T. Mizuno, K. Kamada, H. Tochio, Yasumasa Chiba, K. Yanagi, Gentaro Yasuda, H. Hiroaki, F. Hanaoka, M. Shirakawa   +9 more
semanticscholar   +1 more source

Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional profiling of E7-expressing cells [PDF]

, 2016
The E7 oncoprotein of the high-risk human papillomavirus (HPV) plays a major role in HPV-induced carcinogenesis. E7 abrogates the G(1) cell cycle checkpoint and induces genomic instability, but the mechanism is not fully understood.
Chen, Jason J, Gao, Ge, Liu, Yafei, Wang, Xiaowei, Yuan, Shoudao, Zhang, Qishu, Zhang, Xiaoli, Zhou, Yunying   +7 more
core   +3 more sources

The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle [PDF]

, 2012
Recent genome-wide mapping of the mammalian replication origins has suggested the role of transcriptional regulatory elements in origin activation. However, the nature of chromatin modifications associated with such trans-factors or epigenetic marks ...
Kumar, V, Singh, AK, Swarnalatha, M
core   +1 more source