Results 71 to 80 of about 31,191 (185)

Covalent Inhibition of the Peptidyl‐Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2‐OS Cells

PROTEOMICS, Volume 25, Issue 14, July 2025.
ABSTRACT Peptidyl‐prolyl isomerase, NIMA‐interacting protein 1‐(Pin1) catalyses the cis–trans interconversion of the inflexible bond between serine or threonine residues and proline at the +1 position (pSer/pThr‐Pro). Although initially discovered as an essential regulator of cell division, Pin1 has since been identified as a regulator of many ...
Scott E. Roffey, Owen Hovey, Kristina Jurcic, Kun Ping Lu, Xiao Zhen Zhou, David W. Litchfield   +5 more
wiley   +1 more source

Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation*

Journal of Biological Chemistry, 2011
Background: Cdt1 is a DNA replication factor that loads MCM helicase onto chromatin. SNF2H is a chromatin remodeler. Results: Recruitment of SNF2H to replication origins is Cdt1-dependent and promotes MCM loading.
Nozomi Sugimoto, T. Yugawa, Masayoshi Iizuka, T. Kiyono, M. Fujita   +4 more
semanticscholar   +1 more source

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

Advanced Science, Volume 12, Issue 22, June 12, 2025.
This study reveals histone lactylation as a metabolic‐epigenetic regulator countering cellular senescence and skeletal muscle aging. Reduced lactylation impairs cell cycle, DNA repair and proteostasis pathways, while exercise restores glycolytic activity and lactylation levels, preserving muscle function.
Fanju Meng, Jianuo He, Xuebin Zhang, Wencong Lyu, Ran Wei, Shiyi Wang, Zhehao Du, Haochen Wang, Jinlong Bi, Xueyang Hua, Chao Zhang, Yiting Guan, Guoliang Lyu, Xiao‐Li Tian, Lijun Zhang, Wenbing Xie, Wei Tao   +16 more
wiley   +1 more source

Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function [PDF]

, 2014
Eukaryotic cells license each DNA replication origin during G1 phase by assembling a prereplication complex that contains a Mcm2-7 (minichromosome maintenance proteins 2-7) double hexamer.
Fernandez-Cid, A., Li, H., Riera, A., Speck, C., Stillman, B., Sun, J., Tognetti, S., Yuan, Z.   +7 more
core   +1 more source

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

Effects of environmental temperature on growth performance, muscle fiber structure, fatty acid composition, and gene expression in ducks

Poultry Science
This study aims to elucidate the effects of environmental temperature on growth performance, pectoral muscle fiber structure, fatty acid composition, and gene expression in ducks.
Ziyi Pan, Congcong Xu, Dongyue Sun, Xingda Yang, Rihong Guo, Zichun Dai, Fang Chen, Zhendan Shi, Shijia Ying   +8 more
doaj   +1 more source

Running title: Maximal loading of MCM2/4 in late G1 [PDF]

, 2013
Once-per-cell cycle replication is regulated through the assembly onto chromatin of multisubunit protein complexes that license DNA for a further round of replication.
Bastiaens, Philippe, Grecco, Hernan Edgardo, Kotsantis, Panagiotis, Lygerou, Zoi, Rapsomaniki, Maria Anna, Roukos, Vassilis, Symeonidou, Ioanna Eleni, Taraviras, Stavros   +7 more
core   +1 more source

Ubiquitylation, neddylation and the DNA damage response. [PDF]

, 2015
Failure of accurate DNA damage sensing and repair mechanisms manifests as a variety of human diseases, including neurodegenerative disorders, immunodeficiency, infertility and cancer.
Brown, Jessica S, Jackson, Stephen P
core   +2 more sources

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

Cytoskeleton, Volume 82, Issue 6, Page 372-387, June 2025.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma   +9 more
wiley   +1 more source

Replication fork instability and the consequences of fork collisions from rereplication [PDF]

, 2016
Replication forks encounter obstacles that must be repaired or bypassed to complete chromosome duplication before cell division. Proteomic analysis of replication forks suggests that the checkpoint and repair machinery travels with unperturbed forks ...
Alexander, Jessica Lynne, Orr-Weaver, Terry   +1 more
core   +1 more source