Results 81 to 90 of about 31,191 (185)

CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration [PDF]

, 2013
The Cul4-Cdt2 (CRL4(Cdt2)) E3 ubiquitin ligase is a master regulator of cell-cycle progression and genome stability. Despite its central role in the degradation of many cell-cycle regulators, e.g., Cdt1, p21, and Pr-Set7/Set8, little is known about the ...
Abbas, Tarek, Dutta, Anindya, Keaton, Mignon, Mueller, Adam C., Rossi, Mario, Shibata, Etsuko   +5 more
core   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. [PDF]

, 2018
RationaleMutations in the transcription factor TBX20 (T-box 20) are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by embryonic day 9.5.
Aneas, Ivy, Bogomolovas, Julius, Boogerd, Cornelis J, Chen, Ju, Evans, Sylvia M, Joslin, Amelia C, Montefiori, Lindsey, Nobrega, Marcelo A, Sakabe, Noboru, Sobreira, Debora R, Zhang, Lunfeng, Zhou, Bin, Zhu, Xiaoming   +12 more
core   +2 more sources

Phosphoregulation of Cdt1 in G2 and M phases prevents re-replication independently of Geminin

bioRxiv, 2018
DNA replication origin licensing, the process of MCM helicase loading, is an early essential step in replication and should be restricted to G1 phase to avoid re-replication and genome instability.
Yizhuo Zhou, Haley M Stone, Seeun Oh, Pedro N Pozo, J. Cook   +4 more
semanticscholar   +1 more source

LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study elucidates the mechanism underlying LINC01235 promotes clonal evolution and selection under treatment pressure by facilitating DNA replication licensing and CIN, leading to increased therapeutic resistance in HER2+ breast cancer. Targeting LINC01235‐related pathways with ATR inhibitors may be a viable strategy for clinical application ...
Qi Zhang, Xuliren Wang, Zhibo Shao, Yi Zhang, Liyi Zhang, Ming Chen, Xujie Zhou, Han Zhu, Yue Zhou, Xinya Lu, Pei Li, Weiru Chi, Lun Li, Zhi‐Ming Shao, Shenglin Huang, Jingyan Xue, Yayun Chi, Jiong Wu, Bingqiu Xiu   +18 more
wiley   +1 more source

DNA Replication Factor Cdt1 [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Targeting TTK Inhibits Tumorigenesis of T‐Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway

Advanced Science, Volume 12, Issue 10, March 13, 2025.
In the study, aberrant expression of threonine tyrosine kinase (TTK) in TCL is identified. High expression of TTK is closely associated with poor prognosis in TCL patients. Inhibition of TTK, by either knockdown or specific inhibitor CFI‐402257, exerts anti‐tumor effects in vitro and in vivo.
Bingyu Liu, Tiange Lu, Mengfei Ding, Xiaoli Zhou, Yujie Jiang, Juanjuan Shang, Wenyue Sun, Shunfeng Hu, Xin Wang, Xiangxiang Zhou   +9 more
wiley   +1 more source

Diversity of DNA replication in the archaea [PDF]

, 2017
DNA replication is arguably the most fundamental biological process. On account of their shared evolutionary ancestry, the replication machinery found in archaea is similar to that found in eukaryotes.
Akita, Aves, Bell, Coker, Darya Ausiannikava, O’Donnell, Thorsten Allers   +6 more
core   +3 more sources

HN1 is a novel dedifferentiation factor involved in regulating the cell cycle and microtubules in SH‐SY5Y neuroblastoma cells

Journal of Cellular Biochemistry, Volume 126, Issue 1, January 2025.
Abstract Hematological and neurological expressed 1 (HN1), encoding a small protein, has been recently explored in different cancers owing to its higher expression in tumor samples as compared to adjacent normal. It was discovered and subsequently named because of its higher expression in hematological and neurological tissues in developing mice ...
Tilbe Özar, Aadil Javed, Gülseren Özduman, Kemal S. Korkmaz   +3 more
wiley   +1 more source

The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase [PDF]

, 2014
CDT2/L2DTL/RAMP is one of the substrate receptors of the Cullin Ring Ubiquitin Ligase 4 that targets for ubiquitin mediated degradation a number of substrates, such as CDT1, p21 and CHK1, involved in the regulation of cell cycle and survival.
Arena, Sabrina, Dettori, Daniela, Di Renzo, Maria Flavia, Lantelme, Erica, Olivero, Martina, Zecchin, Davide   +5 more
core   +3 more sources