Advanced Science, Volume 12, Issue 14, April 10, 2025.This study elucidates the mechanism underlying LINC01235 promotes clonal evolution and selection under treatment pressure by facilitating DNA replication licensing and CIN, leading to increased therapeutic resistance in HER2+ breast cancer. Targeting LINC01235‐related pathways with ATR inhibitors may be a viable strategy for clinical application ...
Qi Zhang +18 more
wiley +1 more source
Die Rolle der AAA+ -ATPase p97 in der Regulation der Aktivierung des Zellzykluskontrollpunkt nach DNA Schaden [PDF]
, 2015 Der Zellzyklus ist ein streng regulierter Prozess, welcher die exakte Replikation und Segregation des genetisches Materials in zwei Tochterzellen reguliert.
Riemer, Anne
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Nuclear DNA Replication in Trypanosomatids:There Are No Easy Methods for Solving Difficult Problems [PDF]
, 2017 In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments.
Albalat +103 more
core +4 more sources
Chek2ing out the p53 pathway: Can Puma lead the way? [PDF]
, 2011 Comment on: Kabacik S, et al.
Hollstein, Monica, Hupp, Ted
core +1 more source
DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis. [PDF]
, 2019 The sources of genome instability, a hallmark of cancer, remain incompletely understood. One potential source is DNA rereplication, which arises when the mechanisms that prevent the reinitiation of replication origins within a single cell cycle are ...
Bui, Duyen T, Li, Joachim J
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An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly [PDF]
, 2013 In Saccharomyces cerevisiae and higher eukaryotes, the loading of the replicative helicase MCM2-7 onto DNA requires the combined activities of ORC, Cdc6, and Cdt1. These proteins load MCM2-7 in an unknown way into a double hexamer around DNA.
Evrin, C +9 more
core +1 more source
Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex [PDF]
, 2016 All organisms ensure once and only once replication during S phase through a process called replication licensing. Cdt1 is a key component and crucial loading factor of Mcm complex, which is a central component for the eukaryotic replicative helicase. In
Haruhiko Takisawa +4 more
core +1 more source
Emergent properties of the G1/S network [PDF]
, 2010 Tato práce se zabývá buněčným cyklem kvasinky Saccgaromyces cerevisiae. Oblastí našeho zájmu je přechod mezi G1 a S fází, kde je naším cílem identifikovat velikosti buňky v době počátku DNA replikace.
Dražková, Jana
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Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis [PDF]
, 2016 Precise duplication of the genome is a prerequisite for the health and longevity of multicellular organisms. The temporal regulation of origin specification, replication licensing, and firing at replication origins is mediated by the cyclin-dependent ...
Copeland, Nikki A. +3 more
core +2 more sources
Replikatiivse helikaasikompleksi MCM2-7 subühikute taseme reguleerimine oksüdatiivse stressi sensorvalk KEAP1 poolt [PDF]
, 2016 Replikatiivne helikaasikompleks MCM2-7 omab väga olulist rolli DNA replikatsiooni initsiatsioonis ja selle regulatsioonis. Oksüdatiivse stressi sensorvalk KEAP1 interakteerub helikaasi subühikutega MCM3 ja MCM7, kuid selle interaktsiooni roll rakus ei ...
Raja, Gerda
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